%0 Journal Article
%T Changes in serum lactate dehydrogenase as a prognostic factor in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors.
%A Lee WH
%A Takenaka Y
%A Hosokawa K
%A Eguchi H
%A Suzuki M
%A Fukusumi T
%A Suzuki M
%A Inohara H
%J Acta Otolaryngol
%V 0
%N 0
%D 2024 Aug 10
%M 39126295
%F 1.698
%R 10.1080/00016489.2024.2381631
%X <B>UNASSIGNED: </B>Lactate dehydrogenase (LDH) is involved in the Warburg effect. Elevated serum LDH is a prognostic marker for metastatic solid cancer.<BR><B>UNASSIGNED: </B>To investigate the prognostic impact of serum LDH in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors (ICIs).<BR><B>UNASSIGNED: </B>This retrospective study included 129 patients treated with ICIs between 2017 and 2023. The effects of pretreatment LDH, LDH at 3 months, and change in LDH during the first 3 months (ΔLDH) on overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method and Cox regression model.<BR><B>UNASSIGNED: </B>The 1-year PFS and OS rates for high and low groups were 6.0% and 30.1% for pretreatment LDH (p = 0.044), 25.7% and 38.3% for on-treatment LDH (p = 0.079), and 14.3% and 38.7% for ΔLDH (p = 0.008), as well as 42.1% and 60.9% for pretreatment LDH (p = 0.109), 56.0% and 80.5% (p < 0.001) for on-treatment LDH, and 31.0% and 81.0% for ΔLDH (p < 0.001), respectively. ΔLDH was an independent prognostic factor for both PFS and OS.<BR><B>UNASSIGNED: </B>ΔLDH can be used to predict ICI treatment outcomes and as a marker in deciding to continue ICI therapy.