■先前的元分析发现,身心干预(MBI)可以改善神经心理健康,并可能增加脑源性生长因子(BDNF)。BDNF是与神经可塑性相关的神经营养因子。
■评估与Site上的对照放松相比的短强度MBI对BDNF的影响,并检查这种变化是否与线粒体功能或与压力相关的神经激素活性有关。
■随机化,控制,在泰国一家医疗中心进行的两期交叉试验.健康冥想天真的护士和职业治疗学生,23个随机分配给MBI,周末在现场放松24次,持续8小时。在这两个时期之间的冲洗期为三个月。所有志愿者都进行了BDNF的血液检测,线粒体氧化磷酸化(OXPHOS),皮质醇,和心率变异性(HRV)测量前和视觉模拟焦虑量表(VAS-A),每个周期后的向前和向后数字跨度。
■共有40名参与者完成了试验。交叉试验分析显示,MBI和现场放松之间的治疗效果显着,平均VAS-A为9.89(95%CI4.81至19.47;P=0.001),血清BDNF为1.24(95%CI0.16至2.32;P=0.04),OXPHOS复合物-1下降0.41(95%CI0.03-0.29p=0.03)。数字跨度没有显着差异,皮质醇,和HRV。
■在健康的冥想中,即使是短时间的MBI也可能比现场放松更增加血清BDNF和减轻焦虑。正念组中OXPHOS复合物1的减少更多,表明氧化应激可能是比与压力相关的神经激素活性更敏感的指标。
UNASSIGNED: The previous metanalysis found that Mind-body intervention (MBI) improves neuropsychologic well-being and may increase brain-derived growth factor (BDNF). BDNF is a neurotrophic factor related to neuroplasticity.
UNASSIGNED: To evaluate the effect of the short intensive MBI compared to control-relaxation on Site on BDNF and examine if this change is related to mitochondria function or stress-related neurohormonal activity.
UNASSIGNED: Randomized, controlled, two-period cross-over trial conducted in a medical center in Thailand. Healthy-meditation naive Nurse and Occupational Therapy Students, 23 assigned randomly to MBI, and 24 relaxations at the site for 8 h during the weekend. The wash-out period was three months between the two periods. All volunteers took the blood test for BDNF, mitochondrial oxidative phosphorylation (OXPHOS), Cortisol, and Heart rate variability (HRV) measurement before and Visual Analogue Scale for Anxiety (VAS-A), forward and backward digit span after each period.
UNASSIGNED: A total of 40 participants finished the trials. The cross over trial analysis showed a significant treatment effect between MBI and Relaxation on-site for the mean VAS-A as 9.89 (95% CI 4.81 to 19.47; P = 0.001), serum BDNF as 1.24 (95% CI 0.16 to 2.32; P = 0.04), and OXPHOS complex-1 was decreased 0.41 (95% CI 0.03-0.29 p = 0.03). There were no significant differences for digit span, cortisol, and HRV.
UNASSIGNED: In healthy meditation naïve females, even a short period of MBI may increase serum BDNF and reduce anxiety more than relaxation on-site. The more reduction of OXPHOS complex-1 in the mindfulness group suggests oxidative stress may be a more sensitive indicator than stress-related neurohormonal activity.