Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.

心肺调节自主神经机制的研究机会 ： 来自国家心脏的报告 ，肺 ，血液研究所和国家卫生研究院办公室主任讲习班。

• 影响指数: 9.531
• 发表时间: Mar 2022
• 来源期刊: JACC Basic Transl Sci
• DOI: 10.1016/j.jacbts.2021.11.003
• PMID: 35411324
• 文章类型: Journal Article
• 作者列表: Mehra R,Tjurmina OA,Ajijola OA,Arora R,Bolser DC,Chapleau MW,Chen PS,Clancy CE,Delisle BP,Gold MR,Goldberger JJ,Goldstein DS,Habecker BA,Handoko ML,Harvey R,Hummel JP,Hund T,Meyer C,Redline S,Ripplinger CM,Simon MA,Somers VK,Stavrakis S,Taylor-Clark T,Undem BJ,Verrier RL,Zucker IH,Sopko G,Shivkumar K

关键词: ACE, angiotensin-converting enzyme; AD, autonomic dysregulation; AF, atrial fibrillation; ANS, autonomic nervous system; Ach, acetylcholine; CNS, central nervous system; COPD, chronic obstructive pulmonary disease; CSA, central sleep apnea; CVD, cardiovascular disease; ECG, electrocardiogram; EV, extracellular vesicle; GP, ganglionated plexi; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HRV, heart rate variability; LQT, long QT; MI, myocardial infarction; NE, norepinephrine; NHLBI, National Heart, Lung, and Blood Institute; NPY, neuropeptide Y; NREM, non-rapid eye movement; OSA, obstructive sleep apnea; PAH, pulmonary arterial hypertension; PV, pulmonary vein; REM, rapid eye movement; RV, right ventricular; SCD, sudden cardiac death; SDB, sleep disordered breathing; SNA, sympathetic nerve activity; SNSA, sympathetic nervous system activity; TLD, targeted lung denervation; asthma; atrial fibrillation; autonomic nervous system; cardiopulmonary; chronic obstructive pulmonary disease; circadian; heart failure; pulmonary arterial hypertension; sleep apnea; ventricular arrhythmia

Abstract

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund\'s SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

摘要

这个虚拟研讨会是由国家心脏组织召开的，肺，血液研究所，与国家卫生研究院主任办公室战略协调办公室合作，并于2020年9月2日至3日举行。目的是组建一个多学科专家组，翻译,以及神经科学和心肺疾病的临床研究，以确定知识差距，指导未来的研究工作，并促进与心肺调节的自主神经机制有关的多学科合作。该小组严格评估了自主神经系统在调节健康心肺功能和心律失常病理生理学中的作用的当前知识状态，心力衰竭,睡眠和昼夜节律功能障碍，和呼吸障碍。利用CommonFund的SPARC（刺激外周活动以缓解疾病）计划的机会与非药物神经调节和基于设备的治疗有关。讨论的共同主题包括知识差距，研究重点,以及开发新的自主神经功能障碍预测标志物的方法。精确靶向神经病理生理机制的方法预示着心律失常的新疗法，心力衰竭,睡眠和昼夜节律生理学，和呼吸障碍也被详细说明。