■本研究旨在解决林芝市农村地区妇女高危型人乳头瘤病毒(HR-HPV)感染状况和HR-HPV亚型分布的现有数据差距,西藏。研究目标包括为HPV疫苗开发提供见解。
■这项研究收集了在林芝市农村妇女中进行的两轮癌症筛查的数据,西藏,从2019年到2022年。使用PCR荧光法对收集的样品进行HR-HPV亚型基因检测。然后分析林芝市农村妇女HR-HPV感染率,西藏,以及不同HR-HPV亚型的感染率及其在不同年龄段的分布。比较了青藏高原以外农村地区和林芝市妇女的感染率。
■共包括15687例病例。林芝市农村地区妇女HR-HPV总体感染率,西藏,为13.00%(2040/15,687),显着高于青藏高原以外农村地区妇女的比率(7.82%(9,249/118,237);χ2=635.7,p<0.001)。HPV感染率最高的是35-39岁年龄组,比率为15.31%(499/3260),显着高于青藏高原以外农村地区同年龄段妇女的7.22%(1827/25,322)的比率(χ2=253.00,p<0.001)。HPV感染率最低的是50-54岁年龄组,比率为9.69%(246/2540),与青藏高原以外同年龄段女性的8.14%(1,604/19,698)的比率有统计学差异(χ2=17.68,p<0.001)。林芝市农村地区女性HR-HPV亚型排名前三位,西藏,是HPV52(20.15%,411/2040),HPV16(12.45%,254/2040),和HPV58(11.96%,244/2040)。这些发现与青藏高原以外农村地区女性的三种HR-HPV亚型相一致。此外,林芝市农村地区35-39岁、40-44岁和45-49岁女性中HR-HPV亚型居前3位,西藏,HPV52、HPV16和HPV58。总之,林芝市农村地区妇女HR-HPV感染率,西藏,与青藏高原以外农村地区的妇女相比,在两个区域之间的前三个HR-HPV亚型的分布中观察到一致的模式。
This study aims to address the existing data gap regarding the status of high-risk human papillomavirus (HR-HPV) infection and the distribution of HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet. The research objectives include providing insights for HPV vaccine development.
The research collected data from two rounds of cancer screening conducted among rural women in Nyingchi City, Tibet, from 2019 to 2022. HR-HPV subtype gene detection was performed using the PCR fluorescence method on the collected samples. And then analyzed the HR-HPV infection rate among rural women in Nyingchi City, Tibet, as well as the infection rate of different HR-HPV subtypes and their distribution across different age groups. A comparison was made between the infection rates of women in rural areas outside the Qinghai-Tibet Plateau and those in Nyingchi City.
A total of 15,687 cases included. The overall HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, was 13.00% (2040/15,687), which was significantly higher than the rate among women in rural areas outside the Qinghai-Tibet Plateau (7.82% (9,249/118,237); χ2 = 635.7, p < 0.001). The highest HPV infection rate was observed in the 35-39 age group, with a rate of 15.31% (499/3260), which was significantly higher than the rate of 7.22% (1827/25,322) among women in the same age group in rural areas outside the Qinghai-Tibet Plateau (χ2 = 253.00, p < 0.001). The lowest HPV infection rate was found in the 50-54 age group, with a rate of 9.69% (246/2540), which was statistically different from the rate of 8.14% (1,604/19,698) among women in the same age group outside the Qinghai-Tibet Plateau (χ2 = 17.68, p < 0.001). The top three HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet, were HPV52 (20.15%, 411/2040), HPV16 (12.45%, 254/2040), and HPV58 (11.96%, 244/2040). These findings align with the top three HR-HPV subtypes among women in rural areas outside the Qinghai-Tibet Plateau. Furthermore, the top three HR-HPV subtypes among women aged 35-39, 40-44, and 45-49 in rural areas of Nyingchi City, Tibet, were HPV52, HPV16, and HPV58. In conclusion, the HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, is significantly higher compared to women in rural areas outside the Qinghai-Tibet Plateau, with consistent patterns observed in the distribution of the top three HR-HPV subtypes between the two regions.