未经证实:在使用芳香化酶抑制剂(AI)治疗的早期乳腺癌(EBC)患者的个体骨折风险评估中,骨矿物质密度(BMD)缺乏敏感性。需要基于风险因素的新的双能X射线吸收法(DXA)。
未经证实:骨小梁评分(TBS),在诊断为EBC的绝经后妇女中评估骨应变指数(BSI)和骨几何结构的DXA参数.目的是探讨它们与形态椎骨骨折(VFs)的关系。受试者分为3组,以评估AI和denosumab对骨几何形状的影响:AI处理减去(AIDen-)或加上(AIDen+)denosumab。
未经评估:共有610名EBC患者进入研究:305名患者为未接受AI治疗,187艾登-,和118艾登+。在AI天真的小组中,VFs的存在与较低的全髋部BMD和T评分以及较高的股骨BSI相关.至于骨骼几何参数,AI-naive骨折患者报告股骨颈狭窄(NN)皮质内宽度显着增加,股骨NN骨膜下宽度,转子间屈曲比(BR),股骨转子间皮质内宽度,股骨干(FS)BR和皮质内宽度,与非骨折患者相比。在AIDen患者中存在VFs时,股骨粗隆间BR和股骨粗隆间皮质厚度显着增加,不是在AIDen+的。横截面积和横截面惯性矩的增加,股骨转子间和FS,仅在AIDen+中与VF显著相关。在所有组中,腰椎BSI或TBS均未发现与VF相关。
UNASSIGNED:EBC患者的骨几何参数与VFs有不同的相关性,AI-naive或AI与denosumab联合治疗。这些数据表明,在3个EBC患者亚组中,有针对性地选择骨折风险参数。
UNASSIGNED: Bone mineral density (BMD) lacks sensitivity in individual fracture risk assessment in early breast cancer (EBC) patients treated with aromatase inhibitors (AIs). New dual-energy X-ray absorptiometry (DXA) based risk factors are needed.
UNASSIGNED: Trabecular bone score (TBS), bone strain index (BSI) and DXA parameters of bone geometry were evaluated in postmenopausal women diagnosed with EBC. The aim was to explore their association with morphometric vertebral fractures (VFs). Subjects were categorized in 3 groups in order to evaluate the impact of AIs and denosumab on bone geometry: AI-naive, AI-treated minus (AIDen-) or plus (AIDen+) denosumab.
UNASSIGNED: A total of 610 EBC patients entered the study: 305 were AI-naive, 187 AIDen-, and 118 AIDen+. In the AI-naive group, the presence of VFs was associated with lower total hip BMD and T-score and higher femoral BSI. As regards as bone geometry parameters, AI-naive fractured patients reported a significant increase in femoral narrow neck (NN) endocortical width, femoral NN subperiosteal width, intertrochanteric buckling ratio (BR), intertrochanteric endocortical width, femoral shaft (FS) BR and endocortical width, as compared to non-fractured patients. Intertrochanteric BR and intertrochanteric cortical thickness significantly increased in the presence of VFs in AIDen- patients, not in AIDen+ ones. An increase in cross-sectional area and cross-sectional moment of inertia, both intertrochanteric and at FS, significantly correlated with VFs only in AIDen+. No association with VFs was found for either lumbar BSI or TBS in all groups.
UNASSIGNED: Bone geometry parameters are variably associated with VFs in EBC patients, either AI-naive or AI treated in combination with denosumab. These data suggest a tailored choice of fracture risk parameters in the 3 subgroups of EBC patients.