目的:银屑病,这是一种慢性的,病因不明的免疫介导性皮肤病,不仅影响皮肤,但也与许多全身性疾病有关,如关节炎,心血管疾病,抑郁症,和恶性肿瘤。尽管牛皮癣患者会遇到许多类型的眼睛受累,干眼症是其中的第一位。葡萄膜炎是一种可能与牛皮癣有关的实体,由于晚期诊断可导致严重的视力丧失,不充分和不适当的治疗。在这次审查中,我们的目的是阐明诊断结果,type,通过汇编从已发表的研究中获得的当前数据,对银屑病患者葡萄膜炎的预后和治疗进行分析,并指导这些患者的随访和治疗。
方法:在PubMed上进行了系统的文献检索,使用关键词包括“牛皮癣”,\"银屑病关节炎\",“葡萄膜炎”,“TNF-抑制剂”,“HLAB27”。
结果:在文献中,频率,明确定义了银屑病关节炎过程中葡萄膜炎的类型和治疗方法。然而,牛皮癣和葡萄膜炎的共存尚未得到澄清,因为很少有发表的研究和这些研究的设计。由于我们检查了现有的研究,我们确定牛皮癣和葡萄膜炎的共存可能是急性或阴险的,并且葡萄膜炎的概率和严重程度随着皮肤和关节受累的严重程度增加而增加。此外,我们发现牛皮癣相关的葡萄膜炎可以是双侧的,慢性,严重进展和高复发率。
结论:非关节炎性银屑病与葡萄膜炎的关系尚未完全阐明。治疗这些疾病的医生必须谨慎,并将患有牛皮癣的患者转诊给眼科医生进行定期检查,即使他们没有眼睛症状。另一方面,眼科医生必须小心葡萄膜炎患者的皮肤和关节受累,不能忽视潜在的疾病。
OBJECTIVE: Psoriasis, which is a chronic, immune-mediated skin disease of unknown etiology, not only affects the skin, but also is linked to many systemic conditions such as arthritis, cardiovascular disease, depression, and malignancy. Although many types of eye involvement are encountered in psoriasis patients, dry eye is the first among them. Uveitis is an entity that can be associated with psoriasis and can cause severe vision loss as a result of late diagnosis, inadequate and inappropriate treatment. In this review, we aimed to shed light on the diagnosis, type, prognosis and treatment of uveitis in psoriasis patients by compiling current datas obtained from published studies and to guide the follow-up and treatment of these patients.
METHODS: A systematic literature search was done on PubMed using key words including \"psoriasis\", \"psoriatic arthritis\", \"uveitis\", \"TNF- inhibitors\", \"HLA B27\".
RESULTS: In the literature, the frequency, type and treatment of uveitis developing in the course of psoriatic arthritis are clearly defined. However, the coexistence of psoriasis and uveitis has not yet been clarified due to few numbers published studies and designs of these studies. Since we examined the existing studies, we determined that the coexistence of psoriasis and uveitis could be acute or insidious, and the probability and severity of uveitis increased as the severity of skin and joint involvement increased. In addition, we found that psoriasis-associated uveitis can be bilateral, chronic, severe progression and with a high recurrence rate.
CONCLUSIONS: The relations between non-arthritic psoriasis and uveitis have not yet been fully elucidated. Physicians who treat these diseases must be cautious, and refer their patients who have psoriasis to an ophthalmologist for periodic examination, even if they do not have eye symptoms. On the other hand, ophthalmologists must be careful in uveitis patients in terms of skin and joint involvement, and must not overlook the underlying disease.