组织胞浆菌病是一种真菌病,与晚期HIV病患者的高死亡率有关。我们的系统评价综合了HIV感染者中由组织胞浆引起的抗原尿症的全球患病率数据。我们搜索了PubMed/Medline,Embase,和Scopus数据库于2023年1月3日进行,以确定横断面和队列研究,评估HIV感染成人中组织血浆抗原尿的患病率。我们计算了点估计和95%CI来总结患病率。在筛选的1294项研究中,我们包括15个。我们发现581/5,096(11%;95%CI11%-12%)HIV感染者和483/3,789名晚期HIV疾病患者(13%;95%CI12%-14%)中存在组织血浆抗原尿症。在患有HIV且症状与组织胞浆菌病一致的人中,组织血浆抗原尿症患病率为14%(95%CI13%-15%;502/3,631名参与者)。我们确定患有晚期艾滋病毒的人,住院病人,和有症状的人可能会受益于使用尿液抗原检测早期检测组织胞浆菌病的系统方法。
Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma--caused antigenuria in persons with HIV. We searched PubMed/Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%-12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%-14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%-15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.