■乳腺癌激素受体谱准确性的逐步提高为靶向内分泌治疗提供了基础,多模式乳腺癌治疗的主要支柱。然而,西非样本量相对较小的研究发现的差异导致了一些相互矛盾的结论和建议.
■这项研究调查了乳腺癌标本雌激素受体(ER)的免疫组织化学(IHC)谱,孕激素受体(PR),人表皮受体2(HER2)/neu,和Ki-67在伊巴丹的一家三级医院,尼日利亚超过12年。
■我们审阅了998份IHC报告,记录的临床病理参数,生物标志物的计算模式,并根据美国临床肿瘤学会/美国病理学家学院的建议对它们进行分层。描述性分析,包括频率,意思是,和中位数是从提取的数据中生成的。
■在998个案例中,975(97.7%)为女性,23(2.3%)为男性。平均年龄为48.84±11.99岁。开放活检是最常见的标本类型(320,41.6%):溃疡的肿块切除术和切开活检,未切除的或不可切除的肿瘤。在这些情况下,246(32.0%)是保乳或消融性手术摘除(乳房切除术/广泛局部切除术/四肢切除术)的样本,通过芯针活检获得203(26.4%)。浸润性导管癌是最常见的组织病理学类型(673,94.5%)。大多数分级肿瘤为中级(444,53.5%)。四百六十九(48.4%)为ER阳性,414例(42.8%)PR阳性,180例(19.4%)为HER2/neu阳性。三百三十四(34.0%)为三阴性。89例患者进行了Ki-67染色,其中61例(68.5%)具有阳性核染色。
■我们队列中的类固醇激素受体和HER-2/neu比例可能比迄今为止在该地区报告的广泛变化的数字更具代表性。我们提倡对乳腺癌样本进行常规的IHC分析,作为个性化内分泌治疗的指南。
UNASSIGNED: Progressive improvement in the accuracy of profiling of hormone receptors in breast cancer provides the basis for targeted endocrine therapy, a major pillar of multimodal breast cancer treatment. However, the disparity in findings from comparatively smaller sample-sized studies in West Africa has led to somewhat conflicting conclusions and recommendations.
UNASSIGNED: This study investigates the immunohistochemical (IHC) profile of breast cancer specimens for estrogen receptor (ER), progesterone receptor (PR), human epidermal receptor-2 (HER2)/neu, and Ki-67 in a tertiary hospital in Ibadan, Nigeria over 12 years.
UNASSIGNED: We reviewed 998 IHC reports, documented clinicopathologic parameters, computed patterns of biomarkers, and stratified them based on the American Society of Clinical Oncology/College of American Pathologists recommendations. Descriptive analysis including frequency, mean, and median were generated from the data extracted.
UNASSIGNED: Out of the 998 cases, 975 (97.7%) were females and 23 (2.3%) were males. The mean age was 48.84 ± 11.99 years. Open biopsies were the most common types of specimens (320, 41.6%): lumpectomy and incisional biopsy of ulcerated, fungating or unresectable tumours. In those cases, 246 (32.0%) were samples of breast-conserving or ablative surgical extirpation (mastectomy/wide local excision/quadrantectomy), and 203 (26.4%) were obtained by core needle biopsies. Invasive ductal carcinoma was the most common histopathological type (673, 94.5%). The majority of graded tumours were intermediate grade (444, 53.5%). Four hundred and sixty-nine (48.4%) were ER positive, 414 (42.8%) were PR positive, and 180 (19.4%) were HER2/neu positive. Three hundred and thirty-four (34.0%) were triple-negative. Eighty-nine cases had Ki-67 staining done, and of these 61 (68.5%) had positive nuclear staining.
UNASSIGNED: Steroid hormone receptors and HER-2/neu proportions in our cohort are likely to be more representative than the widely varied figures hitherto reported in the sub-region. We advocate routine IHC analysis of breast cancer samples as a guide to personalized endocrine therapy.