UNASSIGNED: The present study was performed on 73 female BC patients in the South Egypt Cancer Institute. Blood samples were used for Cav-1, Cav-2, and HER-2/neu genes amplification and expression. In addition, immunohistological analysis of mammaglobin, GATA3, ER, PR, and HER-2/neu was done.
UNASSIGNED: There was a statistically significant association between Cav-1, 2 and HER-2/neu genes expression and the age of patients (P< 0.001). There are increase in the level of Cav-1, 2 and increase in HER-2/neu mRNA expression in groups treated with chemotherapy and group treated with both chemotherapy and radiotherapy compared to each group baseline level of genes mRNA expression before treatment. On the contrary, the group treated with chemotherapy, radiotherapy and hormonal therapy revealed increase on the level of Cav-1, 2 and HER-2/neu mRNA expression when compared with their baseline for the same patients before treatment.
UNASSIGNED: Noninvasive molecular biomarkers such as Cav-1 and Cav-2 have been proposed for use in the diagnosis and prognosis for women with BC.
■本研究是在南埃及癌症研究所对73名女性BC患者进行的。血液样品用于Cav-1、Cav-2和HER-2/neu基因扩增和表达。此外,乳腺球蛋白的免疫组织学分析,GATA3,ER,PR,然后她-2/neu完成了。
■Cav-1,2和HER-2/neu基因表达与患者年龄之间存在统计学上的显着关联(P<0.001)。与治疗前每组基因mRNA表达的基线水平相比,化疗治疗组和化疗和放疗治疗组的Cav-1,2水平增加,HER-2/neumRNA表达增加。相反,接受化疗的组,放疗和激素治疗显示,与治疗前相同患者的基线相比,Cav-1,2和HER-2/neumRNA表达水平升高.
■非侵入性分子生物标志物如Cav-1和Cav-2已被提出用于女性BC的诊断和预后。