PDF(Pubmed)
Abstract：
UNASSIGNED: Breast cancer (BC) plays a major public health in Egyptian woman. In Upper Egypt, there is an increase in incidence of BC compared to other Egyptian areas. Triple-negative BC, estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-neu-negative, is a high-risk BC that lacks the benefit of specific therapy that targets these proteins. Accurate determination of Caveolin-1(Cav-1), Caveolin-2 (Cav-2) and HER-2/neu status have become of major clinical significance in BC by focusing about its role as a tumor marker for response to different therapies.
UNASSIGNED: The present study was performed on 73 female BC patients in the South Egypt Cancer Institute. Blood samples were used for Cav-1, Cav-2, and HER-2/neu genes amplification and expression. In addition, immunohistological analysis of mammaglobin, GATA3, ER, PR, and HER-2/neu was done.
UNASSIGNED: There was a statistically significant association between Cav-1, 2 and HER-2/neu genes expression and the age of patients (P< 0.001). There are increase in the level of Cav-1, 2 and increase in HER-2/neu mRNA expression in groups treated with chemotherapy and group treated with both chemotherapy and radiotherapy compared to each group baseline level of genes mRNA expression before treatment. On the contrary, the group treated with chemotherapy, radiotherapy and hormonal therapy revealed increase on the level of Cav-1, 2 and HER-2/neu mRNA expression when compared with their baseline for the same patients before treatment.
UNASSIGNED: Noninvasive molecular biomarkers such as Cav-1 and Cav-2 have been proposed for use in the diagnosis and prognosis for women with BC.
UNASSIGNED: The present study was performed on 73 female BC patients in the South Egypt Cancer Institute. Blood samples were used for Cav-1, Cav-2, and HER-2/neu genes amplification and expression. In addition, immunohistological analysis of mammaglobin, GATA3, ER, PR, and HER-2/neu was done.
UNASSIGNED: There was a statistically significant association between Cav-1, 2 and HER-2/neu genes expression and the age of patients (P< 0.001). There are increase in the level of Cav-1, 2 and increase in HER-2/neu mRNA expression in groups treated with chemotherapy and group treated with both chemotherapy and radiotherapy compared to each group baseline level of genes mRNA expression before treatment. On the contrary, the group treated with chemotherapy, radiotherapy and hormonal therapy revealed increase on the level of Cav-1, 2 and HER-2/neu mRNA expression when compared with their baseline for the same patients before treatment.
UNASSIGNED: Noninvasive molecular biomarkers such as Cav-1 and Cav-2 have been proposed for use in the diagnosis and prognosis for women with BC.
摘要：
■乳腺癌（BC）在埃及妇女中起着重要的公共卫生作用。在上埃及,与其他埃及地区相比，BC的发病率有所增加。三阴性BC,雌激素受体（ER）阴性，孕激素受体（PR）阴性，和HER2-neu阴性，是一种高风险的BC，缺乏针对这些蛋白质的特定疗法的益处。Caveolin-1(Cav-1)的准确测定,Caveolin-2（Cav-2）和HER-2/neu状态已在BC中具有重要的临床意义，因为它专注于其作为响应不同疗法的肿瘤标志物的作用。
■本研究是在南埃及癌症研究所对73名女性BC患者进行的。血液样品用于Cav-1、Cav-2和HER-2/neu基因扩增和表达。此外,乳腺球蛋白的免疫组织学分析，GATA3,ER,PR,然后她-2/neu完成了。
■Cav-1，2和HER-2/neu基因表达与患者年龄之间存在统计学上的显着关联（P<0.001）。与治疗前每组基因mRNA表达的基线水平相比，化疗治疗组和化疗和放疗治疗组的Cav-1，2水平增加，HER-2/neumRNA表达增加。相反,接受化疗的组，放疗和激素治疗显示,与治疗前相同患者的基线相比,Cav-1,2和HER-2/neumRNA表达水平升高.
■非侵入性分子生物标志物如Cav-1和Cav-2已被提出用于女性BC的诊断和预后。
■本研究是在南埃及癌症研究所对73名女性BC患者进行的。血液样品用于Cav-1、Cav-2和HER-2/neu基因扩增和表达。此外,乳腺球蛋白的免疫组织学分析，GATA3,ER,PR,然后她-2/neu完成了。
■Cav-1，2和HER-2/neu基因表达与患者年龄之间存在统计学上的显着关联（P<0.001）。与治疗前每组基因mRNA表达的基线水平相比，化疗治疗组和化疗和放疗治疗组的Cav-1，2水平增加，HER-2/neumRNA表达增加。相反,接受化疗的组，放疗和激素治疗显示,与治疗前相同患者的基线相比,Cav-1,2和HER-2/neumRNA表达水平升高.
■非侵入性分子生物标志物如Cav-1和Cav-2已被提出用于女性BC的诊断和预后。
