PDF(Pubmed)
Abstract：
The COVID-19 pandemic has catalyzed unprecedented scientific data and reagent sharing and collaboration, which enabled understanding the virology of the SARS-CoV-2 virus and vaccine development at record speed. The pandemic, however, has also raised awareness of the danger posed by the family of coronaviruses, of which 7 are known to infect humans and dozens have been identified in reservoir species, such as bats, rodents, or livestock. To facilitate understanding the commonalities and specifics of coronavirus infections and aspects of viral biology that determine their level of lethality to the human host, we have generated a collection of freely available clones encoding nearly all human coronavirus proteins known to date. We hope that this flexible, Gateway-compatible vector collection will encourage further research into the interactions of coronaviruses with their human host, to increase preparedness for future zoonotic viral outbreaks.
摘要：
新冠肺炎疫情催化了前所未有的科学数据和试剂共享与合作，这使人们能够以创纪录的速度了解SARS-CoV-2病毒的病毒学和疫苗开发。大流行，然而,还提高了人们对冠状病毒家族构成的危险的认识，其中7种已知感染人类，数十种已在水库物种中被鉴定出来，比如蝙蝠,啮齿动物,或牲畜。为了促进了解冠状病毒感染的共性和细节以及决定其对人类宿主的致死率的病毒生物学方面，我们已经收集了一个免费的克隆，编码迄今为止已知的几乎所有人类冠状病毒蛋白。我们希望这种灵活，网关兼容的载体收集将鼓励进一步研究冠状病毒与其人类宿主的相互作用，加强对未来人畜共患病毒爆发的准备。
