■松果墙。叶被用作治疗高血压和糖尿病的传统药物。与它的功效不同,这种植物长期给药的安全性尚未得到研究.因此,本研究调查了金鸡叶对大鼠的亚慢性毒性。
■Wistar白化病大鼠,10/性别/组随机分为四组。I-III组分别接受250、500和1000mg/kg体重的70%S的乙醇提取物。几内亚连续90天。第IV组(对照)接受蒸馏水。在整个实验过程中,进行了临床观察,还测量了大鼠的食物摄入量和体重。最后,不同的生化参数,器官重量,并对肝脏和肾脏的组织病理学进行了评估。
■给予S.的70%乙醇提取物。guineense叶减少了测试动物的食物摄入量和体重增加。用1000mg/kg的苦参碱提取物处理的大鼠显示血清丙氨酸转氨酶显著增加,天冬氨酸转氨酶,和碱性磷酸酶水平。在用500和1000mg/kg体重的S.guineense治疗的雌性大鼠中,血清尿素水平也增加。此外,与对照组相比,用1000mg/kg体重处理的大鼠的血糖水平显着降低。然而,任何给药剂量均未显著改变肝脏和肾脏的组织学.
■S.在1000毫克/千克体重的剂量下,大鼠的食物消耗受到影响,体重增加,血清中的肝脏和肾脏酶水平表明,高剂量摄入葛根素可能是有毒的。因此,应好奇和谨慎地自由消费丹麦叶。
UNASSIGNED: Syzygium guineense Wall. leaf is being used as a traditional medicine against hypertension and diabetes mellitus. Unlike its efficacy, the safety profile of this plant upon long-term administration has not been investigated yet. Therefore, this study investigated the sub-chronic toxicity of S. guineense leaves in rats.
UNASSIGNED: Wistar albino rats, 10/sex/group were randomly assigned into four groups. Group I-III respectively received 250, 500, and 1000 mg/kg of body weight of 70 % ethanol extract ofS. guineense leaves for 90 consecutive days. Group IV (control) received distilled water. Throughout the experiment, clinical observations were carried out, food intake and weight of the rats also were measured. Finally, different biochemical parameters, organ weight, and histopathology of liver and kidneys were evaluated.
UNASSIGNED: Administration of 70 % ethanol extract ofS. guineense leaves decreased food intake and body weight gain of the test animals. Rats treated with 1000 mg/kg of S. guineense extract showed significantly increased serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels. Serum urea levels also increased in female rats treated with 500 and 1000 mg/kg body weight of S. guineense. Moreover, the blood glucose level of rats treated with 1000 mg/kg body weight was significantly decreased compared to the control group. However, the histology of the liver and kidneys were not significantly altered by any of the doses administered.
UNASSIGNED: Administration ofS. guineense in rats at a dose of 1000 mg/kg body weight affected the food consumption, weight gain, and serum levels of liver and kidney enzymes suggesting that S. guineense intake at high doses may be toxic. Therefore, liberal consumption of S. guineense leaves should be taken curiously and cautiously.