颗粒状角化不全(GP)是一种罕见的,特发性,和自限性皮肤疾病。临床上表现为红斑至棕色角化过度或鳞片状丘疹,可合并形成斑块。如果临床怀疑GP,组织病理学确认足以诊断。尝试了几种治疗方式,取得了不同的成功,但没有一个是一贯有效的。鉴于GP的稀有性及其临床表现和管理的多样性,我们报告一例自我解决的腹下GP.我们的病人是一名47岁的女性,有一周的无症状史,多个,线性,水平,棕色,腹内褶皱色素沉着的鳞状丘疹。她有三年使用杏仁油和Sudocrem抗菌治疗霜的历史。组织病理学显示角质层角化不全区域内保留有嗜碱性角化透明颗粒,这与GP一致。她用润肤剂出院了,一个月后的随访中,她的病变完全解决了.总之,GP是一种罕见的皮肤疾病,其特征是角化过度的斑块或丘疹,通常在三间隙区域。疾病的自然史可能从自发消退到打蜡和衰落的状况有所不同。此外,考虑到这种疾病的罕见程度及其不同的病因和病程,明确的管理尚未建立,缺乏标准化的治疗建议。
Granular parakeratosis (GP) is a rare, idiopathic, and self-limiting cutaneous disorder. It clinically presents as erythematous to brown hyperkeratotic or scaly papules that can coalesce to form plaques. If GP is suspected clinically, histopathological confirmation is adequate for diagnosis. Several treatment modalities were tried with varying success, but none was consistently efficacious. Given the rarity of GP and the variety in its clinical presentation and management, we report a case of a self-resolving infra-abdominal GP. Our patient is a 47-year-old female who presented with a one-week history of asymptomatic, multiple, linear, horizontal, brown, hyperpigmented scaly papules in the infra-abdominal fold. She had a three-year history of applying almond oil and Sudocrem Antiseptic Healing Cream®. Histopathology showed the retention of basophilic keratohyalin granules within the area of parakeratosis in the stratum corneum, which is consistent with GP. She was discharged on emollients, and on follow-up one month later, her lesions completely resolved. In conclusion, GP is a rare cutaneous disorder characterized by hyperkeratotic plaques or papules typically on intertriginous areas. The natural history of the disease may vary from spontaneous resolution to a waxing and waning condition. In addition, given how uncommon the disease is and its variable etiologies and course, definite management is yet to be established and a standardized treatment recommendation is lacking.