Global health

全球卫生
  • 文章类型: Journal Article
    SLE对患者和医疗保健专业人员(HCP)提出了重大挑战,在欧洲和世界各地。改善SLE患者的医疗保健结果需要全面了解患者的疾病途径。特别是,SLE患者与专业护理中心之间的地理距离,再加上风湿病学家的匮乏,加剧了诊断和管理的延误。此外,最初的SLE症状通常是非特异性的,为主要的HCPs和其他非专业人员提供指导非常重要。改善获得治疗的机会也很重要,在几个欧洲国家和许多低收入和中等收入国家(LMICs),最近批准的几种SLE疗法都没有。此外,在这些治疗方法可用的LMIC中,他们并不总是被医疗保健系统覆盖,使社会经济地位较低的人几乎不可能进入。欧盟内部已经有一些规定,改善罕见和复杂疾病患者获得护理的机会,包括患有SLE的人。特别是,欧洲参考网络(ERN),例如用于自身免疫性疾病的ERNReCONNET,是涉及欧洲HCP的虚拟网络,旨在改善需要高度专业化治疗以及知识和资源集中的罕见和复杂疾病患者的护理。此外,狼疮患者组织如欧洲狼疮在提高对SLE的认识和倡导改善获得护理方面发挥着至关重要的作用。一起,我们可以朝着未来努力,让所有患有狼疮的人都得到应有的全面及时的照顾。
    SLE presents significant challenges for patients and health-care professionals (HCPs), both across Europe and worldwide. Improving health-care outcomes for patients with SLE requires a comprehensive understanding of patient disease pathways. In particular, the geographical distance between SLE patients and specialized care centres, combined with the scarcity of rheumatologists, exacerbates delays in diagnosis and management. Also, the initial SLE symptoms can often be non-specific, and providing guidelines for primary HCPs and other non-specialists is extremely important. Improvement in access to treatment is also important, with several recently approved therapies for SLE not being available in several European countries and many low- and middle-income countries (LMICs). Furthermore, in the LMICs in which these treatments are available, they are not always covered by the health-care system, making their access almost impossible for those of lower socio-economic status. A number of provisions are already in place within the European Union, to improve access to care for patients with rare and complex diseases, including those with SLE. In particular, European Reference Networks (ERNs), such the ERN for Autoimmune Diseases ReCONNET, are virtual networks involving HCPs across Europe with the aim of improving the care of patients with rare and complex diseases that require highly specialized treatment and a concentration of knowledge and resources. In addition, lupus patient organizations such as Lupus Europe play a crucial role in raising awareness of SLE and advocating for improved access to care. Together, we can work towards a future where all people living with lupus receive the comprehensive and timely care they deserve.
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  • 文章类型: Journal Article
    旨在对公共卫生之间的不可分割性进行理论思考,考虑到复杂的思维,行星健康和护理过程,旨在促进健康和可持续发展。研究采用理论反思的方法,从捍卫公共卫生和行星健康之间不可分割性的当代作者那里获得书目来源,同时,为护理过程提供理论系统支持,在感应临界偏置下。护理过程被认为是一个复杂的现象,其中包括相互依赖的动力学,对话的方法,批判性反思感知和未来领导力。对护理过程和可持续发展的理论思考提出了扩展的,情境化和相互依赖的观察护理专业人员在不同健康环境中的作用,为了不损害福祉和环境健康。
    The aim is to conduct theoretical reflection on the inseparability among public health, planetary health and the nursing process in light of complexity thinking, with the aim of contributing to healthy and sustainable development. Study with a theoretical-reflexive approach that accessed bibliographical sources from contemporary authors who defend the inseparability between public health and planetary health and, at the same time, provide theoretical-systemic support to the nursing process, under an inductive critical bias. The nursing process is conceived as a complex phenomenon, which comprises interdependent dynamics, dialogical approaches, critical-reflective perception and prospective leadership. Theoretical reflection on the nursing process and sustainable development raises an expanded, contextualized and interdependent look at the role of nursing professionals in different health contexts, in order not to compromise well-being and environmental health.
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  • 文章类型: Journal Article
    抗菌素耐药性(AMR)对人类构成了多方面的威胁,动物,和环境部门。作为回应,自2000年代以来,中国制定了一系列政策。到目前为止,没有对这些政策文件进行全面评估。本研究旨在使用涵盖三个领域的治理框架在国家一级审查AMR政策文件的内容:政策设计;实施工具;以及监测和评估。从2003年到2022年,我们确定了44份来自政府机构网站的AMR文件。我们的发现揭示了三个治理领域的明显差异。应加强政策设计和监测评价领域,特别是在“协调”领域,\'问责制\',\'可持续性\',和“有效性”。从“一个健康”的角度来看,与人类和动物部门相比,环境部门受到的关注较少。有效应对这些挑战需要不同利益攸关方的更坚定承诺和广泛支持。
    Antimicrobial resistance (AMR) poses a multifaceted threat to the human, animal, and environment sectors. In response, China has formulated a series of policies since the 2000s. Thus far, there has been no comprehensive assessment of these policy documents. This study aims to review the content of AMR policy documents at the national level using a governance framework covering three areas: Policy Design; Implementation Tools; and Monitoring and Evaluation. We identified 44 AMR documents from 2003 to 2022 sourced from government agency websites. Our findings have revealed noticeable discrepancies across the three governance areas. The Policy Design and Monitoring and Evaluation areas should be strengthened, particularly in the domains of \'Coordination\', \'Accountability\', \'Sustainability\', and \'Effectiveness\'. From a \'One Health\' perspective, the environment sector has received less attention compared to the human and animal sectors. Effectively addressing these challenges requires a stronger commitment and widespread support from diverse stakeholders.
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  • 文章类型: Editorial
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  • 文章类型: Journal Article
    背景:帕金森病是第二常见的神经退行性疾病,患病率呈上升趋势。我们的目的是调查帕金森病的患病率,1980年至2023年的时间趋势,以及按地点划分的流行率变化,年龄,性别,调查期间,社会人口统计学指数(SDI),人类发展指数(HDI)和研究特征(样本量,诊断标准,和数据源)。
    方法:在本系统综述和荟萃分析中,我们搜索了PubMed,科克伦,WebofScience,Embase,Scopus,和全球健康观察研究报告了从数据库开始到2023年11月1日在普通人群中帕金森病的患病率。我们纳入了研究,如果它们是原始的观察性调查,参与者来自普通人群或基于社区的数据集,并提供了95%CI或足够信息计算95%CI的帕金森病患病率的数值数据。如果研究是在特定人群中进行的,则被排除在外,样本量小于1000,或者是评论文章,病例报告,协议,会议摘要,信件,注释,短通信,海报,和报告。出版物特点(第一作者和出版年份),研究地点(国家,世卫组织区域,SDI,和HDI),调查期间,研究设计,诊断标准,数据源,参与者信息,和患病率数据使用标准表格从文章中提取。两位作者独立评估了资格,并通过与第三作者的讨论解决了差异。我们使用随机效应模型来汇集95%CI的估计值。计算估计的年度百分比变化(EAPC)以评估帕金森病患病率的时间趋势。这项研究在PROSPERO注册,CRD42022364417。
    结果:来自37个国家的83项研究符合分析条件,有56项研究提供了所有年龄段的患病率,53项研究报告了特定年龄的患病率,和26项研究提供了所有年龄和特定年龄的患病率。帕金森病的全球汇总患病率为每1000例1·51例(95%CI1·19-1·88),男性(1·54/1000[1·17-1·96])高于女性(1·49/1000[1·12-1·92],p=0·030)。在不同的调查期间,帕金森病的患病率为每1000例0·90例(0·48-1·44;1980-89),每1000例1·38例(1·17-1·61;1990-99),每1000例1·18例(0·77-1·67;2000-09),每1000例3·81例(2·67-5·14;2010-23)。在2004-23年期间,帕金森病的EAPC患病率显着升高(EAPC16·32%[95%CI6·07-26·58],p=0·0040)比1980-2003年期间(5·30%[0·82-9·79],p=0·022)。世卫组织六个区域的患病率存在统计学上的显著差异。患病率随HDI或SDI增加。根据不同的样本量或诊断标准,帕金森病合并患病率存在相当大的差异。患病率也随着年龄的增长而增加,在60岁以上的个体中达到9·34例/1000(7·26-11·67)。
    结论:自1980年代以来,帕金森病的全球患病率一直在增加,在过去的二十年中,增长更为明显。在HDI或SDI较高的国家,帕金森病的患病率较高。有必要开展更多高质量的帕金森病流行病学研究,特别是在低SDI国家。
    背景:国家自然科学基金.
    有关摘要的中文翻译,请参见补充材料部分。
    BACKGROUND: Parkinson\'s disease is the second most common neurodegenerative disorder, exhibiting an upward trend in prevalence. We aimed to investigate the prevalence of Parkinson\'s disease, temporal trends between 1980 and 2023, and variations in prevalence by location, age, sex, survey period, sociodemographic index (SDI), human development index (HDI), and study characteristics (sample size, diagnostic criteria, and data source).
    METHODS: In this systematic review and meta-analysis we searched PubMed, Cochrane, Web of Science, Embase, Scopus, and Global Health for observational studies that reported Parkinson\'s disease prevalence in the general population from database inception to Nov 1, 2023. We included studies if they were original observational investigations, had participants from the general population or community-based datasets, and provided numerical data on the prevalence of Parkinson\'s disease either with 95% CIs or with sufficient information to calculate 95% CIs. Studies were excluded if they were conducted in a specific population, had a sample size smaller than 1000, or were review articles, case reports, protocols, meeting abstracts, letters, comments, short communications, posters, and reports. The publication characteristics (first author and publication year), study location (countries, WHO regions, SDI, and HDI), survey period, study design, diagnostic criteria, data source, participant information, and prevalence data were extracted from articles using a standard form. Two authors independently evaluated eligibility, and discrepancies were resolved through discussion with the third author. We used random effect models to pool estimates with 95% CIs. Estimated annual percentage change (EAPC) was calculated to assess the temporal trend in prevalence of Parkinson\'s disease. The study was registered with PROSPERO, CRD42022364417.
    RESULTS: 83 studies from 37 countries were eligible for analysis, with 56 studies providing all-age prevalence, 53 studies reporting age-specific prevalence, and 26 studies providing both all-age and age-specific prevalence. Global pooled prevalence of Parkinson\'s disease was 1·51 cases per 1000 (95% CI 1·19-1·88), which was higher in males (1·54 cases per 1000 [1·17-1·96]) than in females (1·49 cases per 1000 [1·12-1·92], p=0·030). During different survey periods, the prevalence of Parkinson\'s disease was 0·90 cases per 1000 (0·48-1·44; 1980-89), 1·38 cases per 1000 (1·17-1·61; 1990-99), 1·18 cases per 1000 (0·77-1·67; 2000-09), and 3·81 cases per 1000 (2·67-5·14; 2010-23). The EAPC of Parkinson\'s disease prevalence was significantly higher in the period of 2004-23 (EAPC 16·32% [95% CI 6·07-26·58], p=0·0040) than in the period of 1980-2003 (5·30% [0·82-9·79], p=0·022). Statistically significant disparities in prevalence were observed across six WHO regions. Prevalence increased with HDI or SDI. Considerable variations were observed in the pooled prevalence of Parkinson\'s disease based on different sample sizes or diagnostic criteria. Prevalence also increased with age, reaching 9·34 cases per 1000 (7·26-11·67) among individuals older than 60 years.
    CONCLUSIONS: The global prevalence of Parkinson\'s disease has been increasing since the 1980s, with a more pronounced rise in the past two decades. The prevalence of Parkinson\'s disease is higher in countries with higher HDI or SDI. It is necessary to conduct more high-quality epidemiological studies on Parkinson\'s disease, especially in low SDI countries.
    BACKGROUND: National Nature Science Foundation of China.
    UNASSIGNED: For the Chinese translation of the abstract see Supplementary Materials section.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    呼吸道合胞病毒(RSV)是一种常见的病毒病原体,每年在5岁以下的儿童中,全球约有3300万例急性下呼吸道感染(LRTI)。高危人群,尤其是早产儿,那些患有潜在慢性肺病的人,先天性心脏病,或者免疫系统受损,痛苦最严重。RSV感染的特征是呼吸道有大量粘液和粘膜下水肿,导致拥堵,时常,严重的呼吸窘迫。基于抗原和PCR的检测用于诊断RSV感染。
    Respiratory syncytial virus (RSV) is a common viral pathogen that accounts about 33 million cases of acute lower respiratory tract infection (LRTI) worldwide in children under the age of 5 years each year. High-risk populations, particularly preterm infants, those with underlying chronic lung disease, congenital heart disease, or compromised immune systems, are afflicted most significantly. RSV infection is characterized by significant amount of mucus and submucosal edema in the respiratory tract, leading to congestion and, oftentimes, significant respiratory distress. Antigen- and PCR-based testing are used to diagnose RSV infection.
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  • 文章类型: Journal Article
    在过去的30年中,许多研究报道了系统性红斑狼疮(SLE)与甲状腺癌之间的关联。然而,在这一研究领域还没有科学计量学分析。对发表的关于SLE与甲状腺癌之间关联的全球文献进行全面的科学计量分析。使用定义的搜索策略从1964年至2023年的第一份出版物从Scopus数据库中检索SLE患者甲状腺癌中的出版物数据。要在关键字之间进行协作映射分析,作者,期刊,和领土,使用了VOSviewer。我们的最终研究产生了246篇科学出版物,引用了8072篇,在48个国家的198种期刊上发表。在过去的20年中观察到了全球上升趋势,2022年出版物数量最多(n=28;11.4%)。美国以74种出版物(30.1%)引领全球生产力排名,其次是中国,有25种出版物(10.2%)。该领域最受欢迎的期刊是“关节炎研究与治疗”和“内分泌学前沿”,“而被共同引用最多的期刊是”自身免疫评论。“排名前三的最多产的作者是伯纳茨基,S、克拉克,A.E.,还有Ramsey-Goldman,R,各9种出版物。这项第一项科学计量学研究全面概述了SLE患者甲状腺癌的状况,评估这一领域50年的学术生产力。
    Over the past 3 decades numerous studies have reported an association between systemic lupus erythematosus (SLE) and thyroid cancers. However, there has been no scientometric analysis in this area of research. To perform a comprehensive scientometric analysis of the global literature published on the association between SLE and thyroid cancers. The data on publications within thyroid cancers in SLE patients were retrieved from the Scopus database using a defined search strategy from its first publication in 1964 to 2023. To conduct a collaboration mapping analysis among keywords, authors, journals, and territories, VOSviewer was utilized. Our final research resulted in 246 scientific publications with 8072 citations, which were published in 198 journals affiliated to 48 countries. A global upward trend has been observed in the last 20 years, with the highest number of publications in the year 2022 (n = 28; 11.4%). The United States led the global productivity ranking with 74 publications (30.1%), followed by China with 25 publications (10.2%). The most popular journals in this field were \"Arthritis Research and Therapy\" and \"Frontiers in Endocrinology,\" while the most co-cited journal was \"Autoimmunity Reviews.\" The top 3 most prolific authors were Bernatsky, S., Clarke, A.E., and Ramsey-Goldman, R with 9 publications each. This first scientometric study comprehensively offered an overview of the status of thyroid cancers in SLE patients, assessing scholarly productivity in this domain over a period of 50 years.
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  • 文章类型: Journal Article
    慢性阻塞性肺疾病(COPD)是全世界三大死因之一。由于该疾病的可预防和可治疗性质以及其患病率,COPD是一项重大的公共卫生挑战。全球慢性阻塞性肺疾病倡议(GOLD)报告提供了对COPD预防的最新证据的回顾以及评估,诊断,和治疗患有这种疾病的人。本文的目的是根据证据提供2024年修订的GOLD报告和当前最佳实践的摘要。
    UNASSIGNED: Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death throughout the world. Because of the preventable and treatable nature of the disease along with its prevalence, COPD represents a major public health challenge. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report provides a review of the most current evidence for prevention of COPD as well as the assessment, diagnosis, and treatment of people with the disease. The purpose of this article is to provide a summary of the 2024 revised GOLD Report and current best practices in accordance with the evidence.
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