结论:目前,已经积累了大量的证据,表明富含多酚的饮食对健康各个方面的有益作用。这些植物化学物质具有衰老保护潜力,可以减缓与衰老相关的病理过程并确保寿命。在这项研究中,进行了综合分析,以确定单个多酚对老虎机标准的依从性。来自实验模型的数据,临床试验,和流行病学研究进行了分析。
背景:已经描述了62种多酚在动物模型中增加寿命并改善衰老的生物标志物。它们通过进化上保守的分子机制起作用,包括兴奋和维持氧化还原稳态,表观遗传调控,对细胞损伤的反应,代谢控制,抗炎和抗衰老活性。流行病学和临床研究表明,某些多酚具有预防和治疗各种疾病的潜力,包括癌症,代谢紊乱,和人类的心血管疾病。
结果:在综述的植物化学物质中,绿原酸,槲皮素,表儿茶素,Genistein,白藜芦醇,姜黄素被鉴定为具有最高老化保护潜力的化合物。然而,缺乏关于多酚增加健康的有效性和安全性的明确信息,预防和治疗人类衰老相关疾病。
结论:考虑到多酚的长期消费,需要进一步的研究来充分了解多酚的影响,代谢修饰和生物利用度,不同组的多酚和其他植物化学物质之间的复杂相互作用,以及它们对不同健康状况的个体的影响。
Significance: Currently, a large amount of evidence of beneficial effects of diets enriched with polyphenols on various aspects of health has been accumulated. These phytochemicals have a geroprotective potential slowing down the pathological processes associated with aging and ensuring longevity. In this study, a comprehensive analysis was conducted to determine the adherence of individual polyphenols to
geroprotector criteria. Data from experimental models, clinical trials, and epidemiological studies were analyzed. Recent Advances: Sixty-two polyphenols have been described to increase the life span and improve biomarkers of aging in animal models. They act via evolutionarily conserved molecular mechanisms, including hormesis and maintenance of redox homeostasis, epigenetic regulation, response to cellular damage, metabolic control, and anti-inflammatory and senolytic activity. Epidemiological and clinical studies suggest that certain polyphenols have a potential for prevention and treatment of various diseases, including cancer, metabolic disorders, and cardiovascular conditions in humans. Critical Issues: Among the reviewed phytochemicals, chlorogenic acid, quercetin, epicatechin, genistein, resveratrol, and curcumin were identified as compounds with the highest geroprotective potential. However, there is a lack of unambiguous information on the effectiveness and safety of polyphenols for increasing health span, preventing and treating aging-associated diseases in humans. Future Directions: Further research is needed to fully understand the effects of polyphenols considering their long-term consumption, metabolic modification and bioavailability, complex interactions between different groups of polyphenols and with other phytochemicals, as well as their effects on individuals with different health status. Antioxid. Redox Signal. 40, 564-593.