Abstract：
Healthy Longevity Medicine aims to optimize health by targeting aging processes across the lifespan. Addressing accelerated aging involves adaptation of lifestyle and the use of geroprotective drugs and supplements, including nutritional supplements and bioactive compounds. The Food and Drug Administration, under the Dietary Supplement Health and Education Act, categorizes bioactive compounds and medicinal products as dietary supplements. While numerous companies sell ingredients that can be deemed geroprotectors, there\'s limited oversight in their quality control. Governmental safety authorities only verify the presence of prohibited compounds, not the accuracy of ingredients listed on labels.Here, Nicotinamide mononucleotide and Urolithin A supplements, easily accessible online or in pharmacies, were tested for their active ingredient content. Results showed a significant deviation from the labeled amounts, ranging from + 28.6% to -100%. This indicates a considerable disparity in the quality of geroprotective supplements.To address this variability, collaboration between and within societies representing healthcare professionals, industry and regulatory bodies is imperative to ensure the quality of geroprotective supplements.
摘要：
健康长寿医学旨在通过针对整个生命周期的衰老过程来优化健康。解决加速衰老涉及适应生活方式和使用老年保护药物和补充剂，包括营养补充剂和生物活性化合物。食品和药物管理局,根据《膳食补充剂健康和教育法》，将生物活性化合物和医药产品归类为膳食补充剂。虽然许多公司出售可以被认为是老虎机的成分，他们的质量控制监督有限。政府安全当局只核实违禁化合物的存在，不是标签上列出的成分的准确性。这里,烟酰胺单核苷酸和尿石素A补充剂，易于在线或在药店访问，进行了活性成分含量测试。结果显示与标记量有显著偏差，范围从+28.6%到-100%。这表明老年保护补充剂的质量存在相当大的差异。为了解决这种可变性，代表医疗保健专业人员的社会之间和内部的合作，行业和监管机构必须确保老年保护补充剂的质量。
