目的:本研究旨在调查东部老年人肝病合并症的危险因素,中央,和中国西部,探索二进制,健康生态模型中肝病的三元和四元共病共因果模式。
方法:使用中国健康与退休纵向研究(CHARLS)的数据分析了9,763名老年人的基本信息。LASSO回归用于确定东部地区的重要预测因子,中央,和中国西部。使用关联规则研究了肝病合并症的模式,并使用地理信息系统分析了空间分布。此外,二进制,三元,和四元网络图被构建来说明肝脏疾病合并症和共同原因之间的关系。
结果:在9,763名老年人中,536人被发现患有肝病合并症,二元或三元合并症是最普遍的。肝病合并症患病率较高的省份主要集中在内蒙古,四川,和河南。确定的最常见的合并症模式是“肝-心-代谢”,“肝肾”,“肝肺”,和“肝-胃-关节炎”。在东部地区,重要的组合模式包括“肝病-代谢性疾病”,“肝病-胃病”,和“肝病-关节炎”,主要影响因素为睡眠时间小于6h,经常喝酒,女性,和日常活动能力。在中部地区,常见的组合模式包括“肝病-心脏病”,“肝病-代谢性疾病”,和“肝病-肾病”,主要影响因素是小学以下的教育水平,婚姻,有医疗保险,锻炼,没有残疾。在西部地区,主要共病模式是“肝病-慢性肺病”,“肝病-胃病”,“肝病-心脏病”,和“肝病-关节炎”,主要影响因素是健康满意度一般或较差,一般或健康状况不佳,剧烈疼痛,没有残疾。
结论:与肝病相关的合并症在整体和局部水平上都表现出特定的聚类模式。通过分析不同地区肝病的共病模式,建立共病共病因果模式,本研究为肝病的防治提供了新的视角和科学依据。
OBJECTIVE: This study aimed to investigate the risk factors for liver disease comorbidity among older adults in eastern, central, and western China, and explored binary, ternary and quaternary co-morbid co-causal patterns of liver disease within a health ecological model.
METHODS: Basic information from 9,763 older adults was analyzed using data from the China Health and Retirement Longitudinal Study (CHARLS). LASSO regression was employed to identify significant predictors in eastern, central, and western China. Patterns of liver disease comorbidity were studied using association rules, and spatial distribution was analyzed using a geographic information system. Furthermore, binary, ternary, and quaternary network diagrams were constructed to illustrate the relationships between liver disease comorbidity and co-causes.
RESULTS: Among the 9,763 elderly adults studied, 536 were found to have liver disease comorbidity, with binary or ternary comorbidity being the most prevalent. Provinces with a high prevalence of liver disease comorbidity were primarily concentrated in Inner Mongolia, Sichuan, and Henan. The most common comorbidity patterns identified were \"liver-heart-metabolic\", \"liver-kidney\", \"liver-lung\", and \"liver-stomach-arthritic\". In the eastern region, important combination patterns included \"liver disease-metabolic disease\", \"liver disease-stomach disease\", and \"liver disease-arthritis\", with the main influencing factors being sleep duration of less than 6 h, frequent drinking, female, and daily activity capability. In the central region, common combination patterns included \"liver disease-heart disease\", \"liver disease-metabolic disease\", and \"liver disease-kidney disease\", with the main influencing factors being an education level of primary school or below, marriage, having medical insurance, exercise, and no disabilities. In the western region, the main comorbidity patterns were \"liver disease-chronic lung disease\", \"liver disease-stomach disease\", \"liver disease-heart disease\", and \"liver disease-arthritis\", with the main influencing factors being general or poor health satisfaction, general or poor health condition, severe pain, and no disabilities.
CONCLUSIONS: The comorbidities associated with liver disease exhibit specific clustering patterns at both the overall and local levels. By analyzing the comorbidity patterns of liver diseases in different regions and establishing co-morbid co-causal patterns, this study offers a new perspective and scientific basis for the prevention and treatment of liver diseases.