背景:这项真实世界的研究评估了疗效,安全,两种全氟丙烷(C3F8)填塞方法联合平坦部玻璃体切除术(PPV)治疗视网膜脱离(RD)的手术参数。
方法:对132例(132只眼)RD患者(38只眼中的纯C3F8,94眼中的混合C3F8)。所有患者均接受C3F8填塞的PPV治疗,随访至少3个月。视网膜再附着率,气体配置和注入的时间,C3F8用量,眼内压(IOP),最佳矫正视力(BCVA),术后眼部炎症,和患者的投诉进行了评估。
结果:单纯C3F8组和混合C3F8组的单次视网膜复位率分别为97.4%和96.8%,分别,差异无统计学意义(P=1.00)。两组最终视网膜复位率分别为100%和97.2%,分别,差异无统计学意义(P=1.00)。气体配置时间,注气时间,纯C3F8组C3F8用量明显较少(均P<0.001)。时间,但不是团体,是两组术后眼压变化的影响因素(P<0.001,P=0.547)。与基线相比,纯C3F8组的IOP估计值在手术后立即显着增加(P<0.001),混合C3F8组术后即刻和术后1~2天明显升高(均P<0.05)。两组患者眼部炎症(P=0.339)和不适症状(P=0.175)无统计学差异。
结论:两种方法C3F8填塞联合PPV治疗RD患者均具有良好的疗效和安全性。但纯C3F8填塞的临床操作更方便,更环保。
BACKGROUND: This real-world study evaluated the efficacy, safety, and operative parameters of two perfluoropropane (C3F8) tamponade methods combined with pars plana vitrectomy (PPV) for retinal detachment (RD).
METHODS: A retrospective study of 132 patients (132 eyes) with RD (pure C3F8 in 38 eyes, mixed C3F8 in 94 eyes). All eyes underwent PPV with C3F8 tamponade and were followed up for at least 3 months. Retinal reattachment rate, time of gas configuration and injection, C3F8 dosage, intraocular pressure (IOP), best corrected visual acuity, postoperative ocular inflammation, and patients\' complaints were evaluated.
RESULTS: The single-surgery retinal reattachment rates of the pure C3F8 group and mixed C3F8 group were 97.4% and 96.8%, respectively, with no significant difference (p = 1.00). The final retinal reattachment rates of the two groups were 100% and 97.2%, respectively, with no significant difference (p = 1.00). The gas configuration time, gas injection time, and C3F8 dosage were significantly less in the pure C3F8 group (all p < 0.001). Time, but not group, was the influencing factor of postoperative IOP changes in the two groups (p < 0.001, p = 0.547, respectively). Compared with the baseline, the IOP estimates of the pure C3F8 group showed a significant increase immediately after surgery (p < 0.001), and the mixed C3F8 group showed a significant increase immediately and 1-2 days after surgery (all p < 0.05). There was no statistical difference in ocular inflammation (p = 0.339) and patients\' complaints of discomfort (p = 0.175) between the two groups.
CONCLUSIONS: Both the two methods of C3F8 tamponade combined with PPV in RD patients showed good efficacy and safety, but the clinical operation of pure C3F8 tamponade was more convenient and eco-friendly.