目的:胰腺癌临床实践指南于2006年由日本胰腺学会首次发布,并于2009年、2013年、2016年和2019年进行了修订。2022年7月,日本新修订了胰腺癌临床实践指南。
方法:对于此修订版,我们根据《2020年准则发展思想手册》制定了一个全新的准则,其中包括等级-分级建议评估的概念,发展,和评估,以便更好地理解当前的指导方针。患者和公众积极参与了指南的制定和实施。
结果:指南包括诊断算法,治疗,化疗,和胰腺癌的精准医学,并涉及7个主题:诊断,手术治疗,辅助治疗,放射治疗,化疗,支架治疗,以及支持性和姑息性医疗。它包括73个临床问题和112个陈述。这些陈述对应于临床问题,证据水平,推荐优势,和协议率。
结论:本指南代表了迄今为止日本最标准的临床和实用管理指南。这是日本2022年胰腺癌临床实践指南的英文摘要,并尝试在全球范围内传播日本指南,以引入日本方法来治疗胰腺癌。
OBJECTIVE: Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised in 2009, 2013, 2016, and 2019. In July 2022, Clinical Practice Guidelines for Pancreatic Cancer was newly revised in Japanese.
METHODS: For this revision, we developed an entirely new guideline according to the Minds Manual for Guideline Development 2020, which includes the concepts of GRADE-Grading Recommendations Assessment, Development, and Evaluation, to enable a better understanding of the current guidelines. Patients and the public were actively involved in both the development and implementation of the guideline.
RESULTS: The guideline includes algorithms for diagnosis, treatment, chemotherapy, and precision medicine of pancreatic cancer, and addresses 7 subjects: diagnosis, surgical therapy, adjuvant therapy, radiation therapy, chemotherapy, stent therapy, and supportive & palliative medical care. It includes 73 clinical questions and 112 statements. The statements correspond to the clinical questions, evidence levels, recommendation strengths, and agreement rates.
CONCLUSIONS: This guideline represents the most standard clinical and practical management guideline available until date in Japan. This is the English synopsis of the Clinical Practice Guidelines for Pancreatic Cancer 2022 in Japanese, and is an attempt to disseminate the Japanese guideline worldwide to introduce the Japanese approach to the clinical management of pancreatic cancer.