Abstract：
To summarize the current therapies for skin cancers, the Japanese Skin Cancer Society issued the first guidelines for skin cancers, including melanoma, squamous cell carcinoma, basal cell carcinoma (BCC), and extramammary Paget\'s disease, in 2007. These guidelines were revised in 2015. Herein, we present the English version of the 2021 edition of the Japanese clinical guidelines for BCC. In the latest edition, all procedures were performed according to the Grading of Recommendations, Assessment, Development and Evaluation systems. The clinical questions that could not be answered were selected for further analysis. A comprehensive literature search, systematic review, and recommendations for each clinical question were determined by a multidisciplinary expert panel comprising dermatologists, a plastic and reconstructive surgeon, and a pathologist. Surgical resection is the gold-standard therapy of BCC. Radiotherapy or topical treatments, other than surgical resection, have been used in some cases. Patients with unresectable or metastatic BCC require systemic therapy. Novel agents, such as immune response modifiers or hedgehog pathway inhibitors, are emerging worldwide for the treatment of BCC. Based on these viewpoints, four relevant clinical questions regarding, surgical resection, radiotherapy, topical treatment, and systemic therapy, were raised in this report that aims to help clinicians select suitable therapies for their patients.
摘要：
总结目前皮肤癌的治疗方法，日本皮肤癌协会发布了第一个皮肤癌指南，包括黑色素瘤,鳞状细胞癌,基底细胞癌（BCC），和Paget的乳房外疾病,2007年。这些准则于2015年修订。在这里，我们介绍2021版日本BCC临床指南的英文版.在最新版本中，所有程序均根据建议分级进行，评估,开发和评估系统。选择无法回答的临床问题进行进一步分析。全面的文献检索，系统审查，每个临床问题的建议由皮肤科医生组成的多学科专家小组确定，整形和重建外科医生，还有病理学家.手术切除是治疗BCC的金标准。放射治疗或局部治疗，除了手术切除，已在某些情况下使用。不可切除或转移性BCC患者需要全身治疗。新型特工，如免疫应答调节剂或刺猬通路抑制剂，正在世界范围内出现BCC的治疗方法。基于这些观点,四个相关的临床问题，手术切除,放射治疗,局部治疗,和全身治疗，本报告旨在帮助临床医生为患者选择合适的治疗方法。
