对石斛水提物的化学研究导致分离出31种成分,其结构通过分析广泛的光谱数据(1D/2DNMR,MS,UV,和ECD),包括先前未描述的两个双苄基,一种糠醛,和一种酚酸,即trigonopolD(1),trigonopolC(2),石竹A(10),和6-(4-羟基-3-甲氧基苯基)-3,6-二氧代己基乙酸酯(30),分别,还有27个已知的。其中,有一种新的天然产品(11),7个化合物(6-7,9,12,20,28,31)为首次从石斛属植物中,和15个化合物(8,13-17,19,21-27,29)为首次从绞股蓝中分离得到。Further,15种化合物(4-5、8、11-12、14-19、22、24、26和29)的抗氧化和抗炎潜力,具有明显的清除DPPH和羟基自由基的能力,以及抑制COX-2和5-LOX的虚拟对接活动,分别。我们的研究可能会引起药用植物分类学家的注意,并为区分石斛属中的其他物种提供潜在的质量标记。
Chemical investigation on the aqueous extract of Dendrobium aphyllum led to the isolation of thirty-one constituents with structures identified by analysis of the extensive spectroscopic data (1D/2D NMR, MS, UV, and ECD), including previously undescribed two bibenzyls, one
furfural, and one phenolic acid, namely trigonopol D (1), trigonopol C (2), dendrofunan A (10), and 6-(4-hydroxy-3-methoxyphenyl)-3,6-dioxohexyl acetate (30), respectively, as well as twenty-seven known ones. Among them, there were one new natural product (11), seven compounds (6-7, 9, 12, 20, 28, 31) described from the genus Dendrobium for the first time, and fifteen compounds (8, 13-17, 19, 21-27, 29) isolated from D. aphyllum for the first time. Further, the antioxidant and anti-inflammatory potentials of fifteen compounds (4-5, 8, 11-12, 14-19, 22, 24, 26, and 29) with significant scavenging capacities against DPPH and hydroxyl radicals, and virtual docking activities inhibiting COX-2 and 5-LOX, respectively. Our study may draw the attention of medicinal plant taxonomists and supply potential quality markers for discrimination of D. aphyllum from other species in Dendrobium genus.