■膀胱过度活动症(OAB)对个体的身体和心理健康的影响逐年增加,如急迫性尿失禁和夜尿症所证明。OAB患者的症状可能受炎症和氧化应激的影响。黄酮类化合物被认为是重要的抗炎和抗氧化剂,这在水果中很常见,茶,蔬菜,等。以前的研究已经证明了黄酮类化合物及其亚类在治疗炎症方面的治疗潜力,和氧化应激。尽管如此,目前仍缺乏探索类黄酮消费之间潜在相关性的研究,特别是在不同的子类中,OAB。因此,本研究旨在调查黄酮类化合物摄入与OAB之间的关系,以确定OAB管理中可能的饮食干预措施.
■我们利用了国家健康与营养调查(NHANES)和美国农业部饮食研究食品和营养数据库(FNDDS)的调查数据,以13063名合格的美国成年人为基础,研究了总黄酮和亚类黄酮的饮食摄入量与OAB风险之间的关系。从两次24小时的饮食回顾中估算了饮食中类黄酮的摄入量。加权多元逻辑回归模型,基于分位数的g计算,受限三次样条模型,并采用分层分析探讨黄酮类化合物摄入量与OAB的关系,分别。
■被诊断为OAB的参与者表现出更高的女性比例,年长的,非西班牙裔黑人,未婚,以前的饮酒者,家庭年收入较低,较低的贫困收入比,受教育程度较低,肥胖和吸烟者的可能性更高。在调整混杂因素后,加权logistic回归模型显示,花青素消费的第三个四分位数和黄酮消费的第二个四分位数与OAB的降低几率显着相关,而总黄酮消费量与OAB的风险没有显着相关性。基于分位数的g计算模型表明,黄酮,花青素和黄酮醇是观察到的负相关的主要因素。此外,限制性三次样条模型表明花青素摄入量与OAB风险之间存在J形非线性暴露-反应相关性(P非线性=0.00164).分层和交互作用分析显示,花青素摄入量与OAB风险之间的关系受年龄(P交互作用=0.01)和受教育程度(P交互作用=0.01)的显着影响。同时发现黄酮摄入量与OAB风险之间的关系因种族(P交互作用=0.02)和体育锻炼持续时间(P交互作用=0.05)而异。
■我们的研究表明,食用富含类黄酮亚类花青素和黄酮的饮食与OAB的风险降低有关,可能在预防OAB发展中提供临床意义。这强调了饮食调整在OAB症状管理中的重要性。
UNASSIGNED: The increasing influence of overactive bladder (OAB) on physical as well as mental health of individuals is becoming more pronounced annually, as evidenced by the urge urinary incontinence and nocturia. Symptoms in OAB patients may be influenced by inflammation and oxidative stress. Flavonoids are recognized as significant anti-inflammatory and antioxidant agents, which are commonly available in fruits, tea, vegetables, etc. Previous research has demonstrated the therapeutic potential of flavonoids and their subclasses in treating inflammation, and oxidative stress. Despite this, there remains a paucity of research exploring the potential correlation between
flavonoid consumption, specifically within distinct subclasses, and OAB. Thus, our study aims to investigate the relationship between
flavonoid intake and OAB to identify possible dietary interventions for OAB management.
UNASSIGNED: We utilized the survey data from the National Health and Nutrition Examination Survey (NHANES) and the USDA Food and Nutrient Database for Dietary Studies (FNDDS) to investigate the relationship between dietary intake of total and subclass flavonoids and the risk of OAB based on 13,063 qualified American adults. The dietary
flavonoid intake was estimated from two 24-h dietary recalls. Weighted multivariate logistic regression model, quantile-based g-computation, restricted cubic spline model, and stratified analysis were used to explore the association between
flavonoid intake and OAB, respectively.
UNASSIGNED: The participants diagnosed with OAB exhibited a higher percentage of being female, older, Non-Hispanic Black, unmarried, former drinkers, having a lower annual household income, lower poverty to income ratio, lower educational attainment, and a higher likelihood of being obese and smokers. Upon adjusting for confounding factors, the weighted logistic regression models revealed that the third quartile of consumption of anthocyanidin and the second quartile of consumption of flavone were significantly associated with the reduced odds of OAB, while total flavonoid consumption did not show a significant correlation with the risk of OAB. The quantile-based g-computation model indicated that flavone, anthocyanidin and flavonol were the primary contributors to the observed negative correlation. Furthermore, the restricted cubic spline models demonstrated a J-shaped non-linear exposure-response association between anthocyanidin intake and the risk of OAB (P nonlinear = 0.00164). The stratified and interaction analyses revealed that the relationship between anthocyanidin intake and the risk of OAB was significantly influenced by age (P interaction = 0.01) and education level (P interaction = 0.01), while the relationship between flavone intake and the risk of OAB was found to vary by race (P interaction = 0.02) and duration of physical activity (P interaction = 0.05).
UNASSIGNED: Our research suggests that consuming a diet rich in
flavonoid subclass anthocyanidin and flavone is associated with a reduced risk of OAB, potentially offering clinical significance in the prevention of OAB development. This underscores the importance of dietary adjustments in the management of OAB symptoms.