UNASSIGNED:我们的目的是使用多重PCR检测方法,调查日本一家急性护理医院在COVID-19大流行期间按季节和年龄划分的呼吸道感染流行病学。
UNASSIGNED:我们使用基于多重PCR的FilmArrayRespiratoryPanel2.1(bioMérieux),在奈良县综合医学中心的有呼吸道症状的门诊患者标本中检测到21种病原体。
未经批准:在3177个案例中,1215人(38.2%)感染了至少一种致病病毒,检测到1641种病毒。检测到的最常见病毒是人鼻病毒/肠道病毒(n=655)和严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)(n=264)。此外,这些病例中有321例(10.1%)感染了两种或多种重叠病毒。SARS-CoV-2和其他病毒共同感染23例。在2020年12月至2021年3月的冬季,检测到的病毒数量相对较低,其次是人类鼻病毒/肠道病毒的激增,呼吸道合胞病毒(RSV),和副流感3型在2021年春季和夏季。虽然人类鼻病毒/肠病毒的数量在2021年夏季之后仍然相对较高,自2021年9月以来检测到的其他病毒数量较低。2021年12月后,SARS-CoV-2的数量迅速增加。
UNASSIGNED:持续监测呼吸道感染的流行病学对于了解COVID-19大流行的长期影响很重要。
UNASSIGNED: We aimed to investigate the epidemiology of respiratory infections by season and age during the COVID-19 pandemic in a Japanese acute care hospital using multiplex PCR testing.
UNASSIGNED: We detected 21 pathogens in specimens from outpatients with respiratory symptoms at the Nara Prefecture General Medical Center using the multiplex PCR-based FilmArray Respiratory Panel 2.1 (bioMérieux).
UNASSIGNED: Of the 3177 cases, 1215 (38.2%) were infected with at least one causative virus, and 1641 viruses were detected. The most common viruses detected were human rhinovirus/enterovirus (n = 655) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 264). Additionally, 321 (10.1%) of these cases were infected with two or more overlapping viruses. There were 23 cases of co-infection with SARS-CoV-2 and other viruses. In the winter months from December 2020 to March 2021, the number of detected viruses was relatively low, followed by the surge of human rhinovirus/enterovirus, respiratory syncytial virus (RSV), and parainfluenza type 3 in the spring and summer of 2021. While the number of human rhinovirus/entero-virus remained relatively high after the 2021 summer, the number of other viruses detected since September 2021 was low. After December 2021, the number of SARS-CoV-2 increased rapidly.
UNASSIGNED: Continuous monitoring of the epidemiology of respiratory infection is important to understand the prolonged impact of the COVID-19 pandemic.