Abstract：
Human metapneumovirus (hMPV) is a respiratory pathogen that can cause lower respiratory tract infections and pneumonia in immunocompetent adults. Pneumonia caused by hMPV is reportedly more likely to cause bronchial wall thickening and ground-glass opacity (GGO). A 44-year-old woman with no significant medical history developed fever, cough, and nausea. Computed tomography of the chest showed scattered GGOs in the right upper lobe and infiltrating shadows with air bronchograms in the left lingual and bilateral lower lobes. The patient was admitted to our hospital for further evaluation. Atypical pneumonia was suspected and lascufloxacin (LSFX) was started. Multiplex polymerase chain reaction (PCR) detected hMPV on hospital day 2 using the FilmArray Respiratory Panel 2.1. Pneumonia due to hMPV was suspected and LSFX was discontinued. The patient subsequently showed spontaneous improvement and was discharged on hospital day 6 after admission. After discharge, pneumonia continued to improve. Early detection of respiratory pathogens using multiplex PCR can help determine the appropriate treatment strategy. As hMPV can also cause lobar pneumonia, we should consider pneumonia due to hMPV in the differential diagnosis of lobar pneumonia.
摘要：
人类偏肺病毒（hMPV）是一种呼吸道病原体，可引起免疫功能正常的成年人的下呼吸道感染和肺炎。据报道，由hMPV引起的肺炎更有可能导致支气管壁增厚和毛玻璃混浊（GGO）。一名44岁无明显病史的女性出现发热,咳嗽,和恶心。胸部计算机断层扫描显示右上叶散布的GGO，左侧舌侧和双侧下叶有空气支气管图浸润的阴影。患者入院作进一步评估。怀疑为非典型肺炎，并开始使用雷舒沙星（LSFX）。多重聚合酶链反应(PCR)使用FilmArray呼吸面板2.1在医院第2天检测hMPV。怀疑由hMPV引起的肺炎，并停用LSFX。患者随后表现出自发改善，并在入院后第6天出院。放电后,肺炎继续好转。使用多重PCR早期检测呼吸道病原体可以帮助确定合适的治疗策略。由于hMPV也会引起大叶性肺炎，在大叶性肺炎的鉴别诊断中,应考虑由hMPV引起的肺炎.
