William Aldren Turner (Fig. 1) was born in Edinburgh, the son of William Turner (1832-1916) who at the time was senior demonstrator in Anatomy at the University, later Professor (1867). His paternal grandmother was Margaret Aldren. He was not related to the American endocrinologist Henry Hubert Turner (1892-1970) who described Turner syndrome (monosomy X) in 1938. Fig. 1 William Aldren Turner (1864-1945).

This article addresses the discrepancy between Edouard Hitzig\'s and David Ferrier\'s findings on the cortical localization of movements in animals and Jean-Martin Charcot\'s findings in humans. The results of Hitzig\'s and Ferrier\'s vivisections were criticized by experimentalists in England and France as discordant, irreproducible, and inconclusive, and they were rejected by clinicians as irrelevant. Charcot addressed the gap between animal and human motor function by correlating motor deficits and focal epileptic seizures in patients to their autopsy findings. By this method he discovered the functional organization of the human motor cortex and produced the first accurate human motor brain map. Ferrier, William Osler, and Hughlings Jackson acknowledged Charcot\'s findings, and his findings guided the first neurosurgeons in localizing and resecting intracranial mass lesions presenting with focal epileptic seizures. Although his contributions in these fields have been neglected by modern historians, Charcot made significant contributions to the neurobiology of the human motor system, to epileptology, and to the birth of modern neurosurgery.

First published in 1878, Brain: A Journal of Neurology is generally considered to be the world\'s first neuroscientific journal. However, this claim might be challenged since the West Riding Lunatic Asylum Medical Reports, another journal with significant neuroscientific content, was published between 1871 and 1876. Some have suggested this journal was the precursor of Brain, since it shared similar subject matter as well as editorial and authorial contributors, including James Crichton-Browne, David Ferrier and John Hughlings Jackson. To address this question, this article examines the origins, aims, structure and contents of, and some of the contributors and contributions to, the West Riding Lunatic Asylum Medical Reports and compares these elements to the first six volumes of Brain (1878-9 to 1883-4). Although the two journals did overlap in terms of some shared neuroscientific interests, Brain evidently had a broader scope and a more international authorship. Nevertheless, this analysis suggests that, through the agency of Crichton-Browne, Ferrier and Hughlings Jackson, it is appropriate to regard the West Riding Lunatic Asylum Medical Reports as not only the antecedent but also the precursor of Brain.

This article is an outline of the transition in \"brain maps\" used to illustrate locations of cortical \"centers\" associated with movements, sensations, and language beginning with images from Gall and Spurzheim in the nineteenth century through those of functional magnetic resonance imaging in the twenty-first century. During the intervening years, new approaches required new brain maps to illustrate them, and brain maps helped to objectify and naturalize mental processes. One approach, electrical stimulation of the cerebral cortex-exemplified by Fritsch and Hitzig in 1870, Ferrier in 1873, and Penfield by 1937-required brain maps showing functional centers with expanded and overlapping boundaries. In another approach, brain maps that linked cortical centers to account for the complex syndromes of aphasia, apraxia, alexia, and agraphia were initially constructed by Baginsky in 1871, Wernicke in 1874, and Lichtheim in 1885, then later by Lissauer in 1890, Dejerine in 1892, and Liepmann in 1920, and eventually by Geschwind in 1965 and others through the late twentieth century. Over that intervening time, brain maps changed from illustrations of points on the cerebral cortex where movements and sensations were elicited to illustrations of areas (centers) associated with recognizable functions to illustrations of connections between those areas that account for complex symptoms occurring in clinical patients. By the end of this period, advancements in physics, mathematics, and cognitive science resulted in inventions that allowed brain maps of cortical locations derived from cognitive manipulations rather than from the usual electrical or ablative manipulations. \"Mental\" dependent variables became \"cognitive\" independent variables.

For a brief period in1826, George Cruickshank (1798-1878), already an established artist in political satire and book illustration, turned to phrenology. He produced one initial print (Bumpology), followed by a collection of six plates of 33 engravings, linked by an explanatory preface, under the title, Phrenological Illustrations or an Artist\'s View of the Craniological System of Doctors Gall and Spurzheim. It was published during what is regarded as \"the phrenological craze\" in Britain. The illustrations were also produced at the height of Cruickshank\'s staggering creative productivity. In 1873, as phrenology was making its exit from scientific credibility into history, Cruickshank\'s phrenological illustrations were reissued by popular demand. Yet in contrast to his other works, these illustrations have received little attention in modern scholarship. The ways and the extent to which his caricatures constitute a contribution to the history of phrenology deserve to be studied. Here they are analyzed together with his descriptions in the prefaces to both the 1826 and 1873 editions. They reveal a surprising knowledge of phrenology in relation to Spurzheim and Gall. Furthermore, their uniquely innovative features will be identified in the context of other contemporary caricatures, and the fundamental significance of Cruickshank\'s achievement and its impact will be evaluated.

Henry Calderwood, a nineteenth-century Scottish philosopher interested in madness, published in 1879 an important work on the interaction between philosophy of mind, the nascent neurosciences and mental disease. Holding a spiritual view of the mind, he considered the phrase \'mental disease\' (as Feuchtersleben had in 1845) to be but a misleading metaphor. His analysis of the research work of Ferrier, Clouston, Crichton-Browne, Maudsley, Tuke, Sankey, etc., is detailed, and his views are correct on the very limited explanatory power that their findings had for the understanding of madness. Calderwood\'s conceptual contribution deserves to be added to the growing list of nineteenth-century writers who started the construction of a veritable \'philosophy of alienism\' (now called \'philosophy of psychiatry\').

There was an increasing medical interest in the localization of representation of function in the cerebral cortex after Broca in 1861 identified a cortical area that appeared responsible for expressive speech. By the late 1860s, John Hughlings Jackson-based on clinico-pathological correlations mainly in persons with focal motor seizures-had reasoned that contralateral somatic motor function was represented in another area of the cortex. This localization was supported by Fritsch and Hitzig (1870) in experimental cortical stimulation studies in dogs. These authors also reported producing events resembling contralateral motor convulsing in their animals. Their work, and Jackson\'s ideas, prompted David Ferrier, in Great Britain, to begin a program of cerebral cortical stimulation studies in various vertebrate species, trying to locate cortical sites of representation of functions other than expressive speech and motor activity. In his initial report of his investigations (1873), he noted that appropriately sited Faradic stimulation evoked immediate or delayed contralateral focal motor seizures, some of which evolved into generalized convulsions. On this basis he reasoned that focal motor and generalized seizures were expressions of the same disorder; that nearly all epilepsies originated in the cerebral cortex and not in the lower brain stem, as hitherto thought; and that the clinical pattern of epileptic seizure phenomenology depended on the function of the cortical site of origin and the extent and direction of spread of seizure activity in the brain. He not only provided experimental verification for Jackson\'s reasoning about epileptic seizure mechanisms but expressed the ideas a good deal more clearly than Jackson ever managed to do. Ferrier\'s achievement in this regard has tended to escape notice, lost sight of because of the great importance of his investigations into localization of cerebral function.

The Cruelty to Animals Act 1876 was an important but ambiguous piece of legislation. For researchers it stymied British science, yet ensured that vivisection could continue under certain restrictions. For anti-vivisection protestors it was positive proof of the influence of their campaigns, yet overly deferent to Britain\'s scientific elite. In previous accounts of the Act and the rise of anti-vivisectionism, scientific medicine central to these debates has been treated as monolithic rather than a heterogeneous mix of approaches; and this has gone hand-in-hand with the marginalizing of provincial practices, as scholarship has focused largely on the \'Golden Triangle\' of London, Oxford and Cambridge. We look instead at provincial research: brain studies from Wakefield and anthrax investigations in Bradford. The former case elucidates a key role for specific medical science in informing the anti-vivisection movement, whilst the latter demonstrates how the Act affected the particular practices of provincial medical scientists. It will be seen, therefore, how provincial medical practices were both influential upon, and profoundly affected by, the growth of anti-vivisectionism and the passing of the Act. This paper emphasises how regional and varied medico-scientific practices were central to the story of the creation and impact of the Cruelty to Animals Act.

This chapter has two emphases, one is about the men who influenced the visual representations that David Ferrier (1843-1928) used to illustrate his work on localization of brain functions during the years 1873-1875, namely, Alexander Ecker, John C. Galton, and Ernest Waterlow, and the other is about the nature of medical representations and of Ferrier\'s illustrations in particular. Medical illustrations are characterized either as pictures, line drawings, or brain maps. Ferrier\'s illustrations will be shown to be increasingly sophisticated brain maps that contrast with early nineteenth-century standards of medical illustrations, as exemplified by John Bell (1763-1829).