背景:非酒精性脂肪性肝病(NAFLD)是一个主要的健康问题,关于其对女性性功能障碍(FSD)的影响的可用信息很少。
目的:我们旨在研究埃及绝经前妇女NAFLD与FSD之间的关系。
方法:根据肝脏超声和脂肪肝指数数据,在我们的NAFLD门诊筛查诊所就诊(2019年至2022年)的性活跃已婚绝经前妇女分为NAFLD组和非NAFLD(对照组)组。所有参与者都完成了阿拉伯女性性功能指数(ArFSFI)问卷。所得数据用于计算领域和总分。然后将FSD分级如下:无FSD(≥28.2),最小(21.7-28.1),轻度(14.5-21.6),中等(7.3-14.4),严重(≤7.2)。
结果:我们确定了ArFSFI评分表示对性生活不满意的患者和对照组的比例。
结果:在995名FSFI评分可用的女性参与者中,在487例(48.9%)中检测到NAFLD,在508例(51.1%)中没有检测到NAFLD。两组在年龄上具有可比性,社会经济水平,residence,女性生殖器切割的历史。NAFLD患者的性唤起平均得分明显低得多,润滑,性高潮,满意,和FSFI的疼痛域(所有P<.001),而与对照组相比,NAFLD患者的欲望域没有发现统计学差异。NAFLD女性的平均总FSFI评分明显低于对照组(平均[SD]16.7[6.8]vs21.7[5.1],分别;P<.001),FSD发生率更高(98.5%vs82.1%;P<.001)。大多数NAFLD女性的FSD等级高于对照组(%):无FSD(1.5,17.9),最小(20.6,51.8),轻度(42.5,38.8),中等(26.2,9.4),严重(10.7,无),分别。
结论:鉴于NAFLD患者中FSD的高患病率,对FSF的更多关注可以改善NAFLD患者的生活质量.
■这项研究受到缺乏性激素测试和其他一些未测试的重要因素的限制(例如,年龄,社会经济水平,residence,和女性生殖器切割),因为这些特征以前是匹配的。研究的优势包括研究规模大,据我们所知,迄今为止最大的研究绝经前女性FSD和NAFLD之间可能的联系,以及包含经过验证的ArFSFI的详细版本。
结论:在埃及绝经前妇女中,NAFLD可能损害其性功能。
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a major health problem with a paucity of available information about its impact on female sexual dysfunction (FSD).
OBJECTIVE: We aimed to study the association between NAFLD and FSD in Egyptian premenopausal women.
METHODS: Sexually active married premenopausal women who visited our NAFLD outpatient screening clinic (2019 to 2022) were divided into NAFLD and non-NAFLD (control) groups based on liver ultrasound and fatty liver index data. All participants completed the Arabic Female Sexual Function Index (ArFSFI) questionnaire. The resulting data were used to calculate the domains and total scores. FSD is then graded as follows: no FSD (≥28.2), minimal (21.7-28.1), mild (14.5-21.6), moderate (7.3-14.4), and severe (≤7.2).
RESULTS: We determined the proportions of patients and controls for whom ArFSFI scores indicated dissatisfaction with their sexual lives.
RESULTS: Of 995 women participants whose FSFI scores were available, NAFLD was detected in 487 (48.9%) and absent in 508 (51.1%). The two groups were comparable in age, socioeconomic level, residence, and history of female genital cutting. The NAFLD patients had significantly much lower mean scores for the sexual arousal, lubrication, orgasm, satisfaction, and pain domains of the FSFI (P < .001 for all), while no statistical difference was noticed in the desire domain for NAFLD patients compared with the controls. NAFLD women had significantly lower mean total FSFI scores than the controls (mean [SD] 16.7 [6.8] vs 21.7 [5.1], respectively; P < .001) with higher rates of FSD (98.5% vs 82.1%; P < .001, respectively). Most NAFLD women had higher FSD grades than controls (%): no FSD (1.5, 17.9), minimal (20.6, 51.8), mild (42.5, 38.8), moderate (26.2, 9.4), and severe (10.7, none), respectively.
CONCLUSIONS: Given the high prevalence of FSD in patients with NAFLD, greater attention to FSF could improve the quality of life in patients with NAFLD.
UNASSIGNED: This study was limited by the lack of testing of sex hormones and some other important factors that were not tested (eg, age, socioeconomic level, residence, and female genital cutting), as these characteristics were previously matched. Strengths of the study include the large study size, to our knowledge the largest to date to investigate the possible link between FSD and NAFLD in premenopausal women, together with the inclusion of the detailed version of the validated ArFSFI.
CONCLUSIONS: In Egyptian premenopausal women, NAFLD could harm their sexual function.