Abstract：
BACKGROUND: Primary Sjögren\'s syndrome (pSS) is an inflammatory autoimmune condition affecting the exocrine glands, which can adversely affect the sexual activities of women with pSS.
OBJECTIVE: The study sought to evaluate the performance of the Female Sexual Function Index (FSFI) score in women with pSS regarding desire, arousal, orgasm, lubrication, satisfaction, and pain compared with those of healthy individuals.
METHODS: A systematic review was conducted by examining studies published up to May 2023 using Embase, Web of Science, Scopus, and PubMed with the search terms \"sexual\" and \"Sjögren\'s syndrome.\"
RESULTS: Out of the 228 articles retrieved, 9 met the criteria for inclusion in this systematic review. Six of these studies were cross-sectional, involving 229 women with pSS and 303 control subjects. Results from the meta-analysis showed that women with pSS had significantly lower scores in all 6 FSFI subdomains and the total FSFI score compared with healthy individuals. Lubrication showed the largest decrease, followed by pain. In addition, women with pSS exhibited significantly higher standardized mean differences in depression and in anxiety, as assessed by the Hospital Anxiety and Depression Scale, when compared with control subjects.
CONCLUSIONS: This updated meta-analysis underscores the importance of assessing genitourinary atrophy, disease-related psychological changes, and dyspareunia in women with pSS. It also emphasizes the need for customized therapeutic approaches to address these sexual dysfunctions effectively.
OBJECTIVE: The study sought to evaluate the performance of the Female Sexual Function Index (FSFI) score in women with pSS regarding desire, arousal, orgasm, lubrication, satisfaction, and pain compared with those of healthy individuals.
METHODS: A systematic review was conducted by examining studies published up to May 2023 using Embase, Web of Science, Scopus, and PubMed with the search terms \"sexual\" and \"Sjögren\'s syndrome.\"
RESULTS: Out of the 228 articles retrieved, 9 met the criteria for inclusion in this systematic review. Six of these studies were cross-sectional, involving 229 women with pSS and 303 control subjects. Results from the meta-analysis showed that women with pSS had significantly lower scores in all 6 FSFI subdomains and the total FSFI score compared with healthy individuals. Lubrication showed the largest decrease, followed by pain. In addition, women with pSS exhibited significantly higher standardized mean differences in depression and in anxiety, as assessed by the Hospital Anxiety and Depression Scale, when compared with control subjects.
CONCLUSIONS: This updated meta-analysis underscores the importance of assessing genitourinary atrophy, disease-related psychological changes, and dyspareunia in women with pSS. It also emphasizes the need for customized therapeutic approaches to address these sexual dysfunctions effectively.
摘要：
背景：原发性干燥综合征（pSS）是一种影响外分泌腺的炎性自身免疫性疾病，这会对患有pSS的女性的性活动产生不利影响。
目的：该研究旨在评估pSS女性的女性性功能指数（FSFI）评分在欲望方面的表现，唤醒,性高潮,润滑,满意,和与健康个体相比的疼痛。
方法：通过使用Embase检查截至2023年5月发表的研究进行了系统评价，WebofScience,Scopus,和PubMed的搜索词“性”和“干燥综合征”。\"
结果：在检索到的228篇文章中，9符合纳入本系统评价的标准。其中六项研究是横断面的，涉及229名女性和303名对照受试者。荟萃分析结果显示，与健康个体相比，患有pSS的女性在所有6个FSFI子结构域和总FSFI得分均显着降低。润滑显示最大的下降，其次是疼痛。此外,患有pSS的女性在抑郁和焦虑方面表现出显著较高的标准化平均差异，根据医院焦虑和抑郁量表评估，与对照组相比。
结论：这项更新的荟萃分析强调了评估泌尿生殖系统萎缩的重要性，疾病相关的心理变化，pSS女性的性交困难。它还强调需要定制的治疗方法来有效地解决这些性功能障碍。
目的：该研究旨在评估pSS女性的女性性功能指数（FSFI）评分在欲望方面的表现，唤醒,性高潮,润滑,满意,和与健康个体相比的疼痛。
方法：通过使用Embase检查截至2023年5月发表的研究进行了系统评价，WebofScience,Scopus,和PubMed的搜索词“性”和“干燥综合征”。\"
结果：在检索到的228篇文章中，9符合纳入本系统评价的标准。其中六项研究是横断面的，涉及229名女性和303名对照受试者。荟萃分析结果显示，与健康个体相比，患有pSS的女性在所有6个FSFI子结构域和总FSFI得分均显着降低。润滑显示最大的下降，其次是疼痛。此外,患有pSS的女性在抑郁和焦虑方面表现出显著较高的标准化平均差异，根据医院焦虑和抑郁量表评估，与对照组相比。
结论：这项更新的荟萃分析强调了评估泌尿生殖系统萎缩的重要性，疾病相关的心理变化，pSS女性的性交困难。它还强调需要定制的治疗方法来有效地解决这些性功能障碍。
