■甘油三酯葡萄糖(TyG)指数是确定胰岛素抵抗(IR)的有效方法。有限的研究探索了TyG指数与高血压患者功能显着狭窄之间的联系。此外,TyG索引之间的连接,脂肪衰减指数(FAI)和动脉粥样硬化斑块特征也值得探讨。
■该研究筛选了1622名没有冠状动脉疾病史的高血压患者,他们接受了冠状动脉计算机断层扫描血管造影术。将TyG指数计算为ln(空腹血糖[mg/dL]*空腹TG[mg/dL]/2)。不良斑块特征(HRPCs),高风险斑块(HRPs),FAI,并对所有患者进行CT衍生的血流储备分数(FFRCT)分析和测量。导致缺血的功能显著狭窄定义为FFRCT≤0.80。基于FFRCT创建两个患者组:FFRCT<0.80组和FFRCT>0.80组。在高血压患者中,采用逻辑回归模型检验了TyG指数与FFRCT之间的相关性.
■与FFRCT>0.80相比,FFRCT≤0.80的人的TyG指数更高。在控制了其他混杂因素后,逻辑回归模型显示,TyG指数与FFRCT≤0.80之间存在明显联系(OR=1.718,95%CI1.097-2.690,p=0.018)。受限三次样条分析显示了TyG指数和FFRCT≤0.80之间的非线性联系(非线性的p=0.001)。TyG指数增加了具有HRPs和HRPC的个体的比例,FAI提出,FFRCT下降(p<0.05)。多元线性回归分析表明,高TyG指数水平与FAI之间存在强大的相关性,FFRCT,正重塑(PR),和低衰减斑块(LAP)(标准化回归系数:0.029[p=0.007],-0.051[p<0.001],0.029[p=0.027],和0.026[p=0.046],单独)。
■在高血压患者中,TyG指数与FFRCT≤0.80的风险表现出良好的相关性。此外,TyG指数也与FAI有关,FFRCT,PR,和LAP。
UNASSIGNED: The triglyceride glucose (TyG) index is an effective method for determining insulin resistance (IR). Limited research has explored the connection between the TyG index and functionally significant stenosis in hypertensive patients. Furthermore, the connections between the TyG index, fat attenuation index (FAI) and atherosclerotic plaque characteristics are also worth exploring.
UNASSIGNED: The study screened 1622 hypertensive participants without coronary artery disease history who underwent coronary computed tomography angiography. The TyG index was calculated as ln (fasting glucose [mg/dL] * fasting TG [mg/dL]/2). Adverse plaque characteristics (HRPCs), high-risk plaques (HRPs), FAI, and CT-derived fractional flow reserve (FFRCT) were analyzed and measured for all patients. Functionally significant stenosis causing ischemia is defined as FFRCT ≤ 0.80. Two patient groups were created based on the FFRCT: the FFRCT < 0.80 group and the FFRCT > 0.80 group. In hypertensive patients, the association between the TyG index and FFRCT was examined applying a logistic regression model.
UNASSIGNED: The TyG index was higher for people with FFRCT ≤ 0.80 contrast to those with FFRCT > 0.80. After controlling for additional confounding factors, the logistic regression model revealed a clear connection between the TyG index and FFRCT ≤ 0.80 (OR = 1.718, 95% CI 1.097-2.690, p = 0.018). The restricted cubic spline analysis displayed a nonlinear connection between the TyG index and FFRCT ≤ 0.80 (p for nonlinear = 0.001). The TyG index increased the fraction of individuals with HRPs and HRPCs, FAI raised, and FFRCT decreased (p < 0.05). The multivariate linear regression analysis illustrated a powerfulcorrelation between high TyG index levels and FAI, FFRCT, positive remodeling (PR), and low-attenuation plaque (LAPs) (standardized regression coefficients: 0.029 [p = 0.007], -0.051 [p < 0.001], 0.029 [p = 0.027], and 0.026 [p = 0.046], separately).
UNASSIGNED: In hypertensive patients, the TyG index showed an excellent association with a risk of FFRCT ≤ 0.80. Additionally, the TyG index was also linked to FAI, FFRCT, PR, and LAPs.