UNASSIGNED: 60 AMI patients undergoing coronary computed tomography angiography and angiography (Jan 2020-Jun 2022) were studied 60 age, gender, BMI-matched stable angina, and 60 non-coronary artery disease patients were included. Siemens VB20.0 measured PCAT-volume and fat attenuation index (FAI). Neutrophil-to-lymphocyte ratio levels were calculated by peripheral blood tests.
UNASSIGNED: The PCAT volume and PCAT-FAI gradually increased across the control, stable angina, and AMI groups, with a corresponding gradual rise in NLR. NLR exhibited weak positive correlation with PCAT-FAI (r=0.35) and PCAT-volume (r=0.24). Multivariable logistic regression identified increased PCAT-volume, PCAT-FAI and neutrophil-to-lymphocyte ratio as possible independent AMI risk factors. No significant PCAT-volume difference was observed between infarct-related artery (IRA) and non-IRA for all three coronary arteries. Only PCAT-FAI around IRA-LAD was higher than non-IRA-LAD (-74.84±6.93 HU vs -79.04±8.68 HU). PCAT-FAI around culprit vessels in AMI was higher than corresponding lesion related vessel in SA. PCAT-volume around narrowed non-IRA in AMI was higher than that of corresponding LRV in SA. PCAT-FAI of narrowed non-IRA-LADs and non-IRA-LCXs in AMI were elevated compared to LADs (-78.46±8.56HU vs -83.13±8.34 HU) and LCXs (-73.83±10.63 HU vs -81.38±7.88 HU) of lesion related vessel in stable angina.
UNASSIGNED: We found an association between AMI and inflammation in the coronary perivascular adipose tissue and systemic inflammatory response.
■60例接受冠状动脉计算机断层扫描血管造影术和血管造影术(2020年1月至2022年6月)的AMI患者60岁,性别,BMI匹配的稳定型心绞痛,纳入60例非冠状动脉疾病患者。西门子VB20.0测量PCAT-体积和脂肪衰减指数(FAI)。通过外周血测试计算中性粒细胞与淋巴细胞的比率水平。
■整个对照中的PCAT音量和PCAT-FAI逐渐增加,稳定型心绞痛,和AMI组,NLR相应逐渐上升。NLR与PCAT-FAI(r=0.35)和PCAT体积(r=0.24)呈弱正相关。多变量逻辑回归确定PCAT体积增加,PCAT-FAI和中性粒细胞与淋巴细胞比值可能是AMI的独立危险因素。在所有三个冠状动脉的梗死相关动脉(IRA)和非IRA之间均未观察到明显的PCAT体积差异。只有IRA-LAD周围的PCAT-FAI高于非IRA-LAD(-74.84±6.93HUvs-79.04±8.68HU)。AMI中罪犯血管周围的PCAT-FAI高于SA中相应的病变相关血管。AMI中狭窄的非IRA周围的PCAT体积高于SA中相应的LRV。AMI中狭窄的非IRA-LAD和非IRA-LCXs的PCAT-FAI与LAD(-78.46±8.56HUvs-83.13±8.34HU)和LCXs(-73.83±10.63HUvs-81.38±7.88HU)相比升高。
■我们发现AMI与冠状动脉血管周围脂肪组织炎症和全身炎症反应之间存在关联。