高胆固醇血症是一种常见病,其特征是低密度脂蛋白胆固醇(LDL-C)水平升高,动脉粥样硬化性心血管疾病(ASCVD)的风险增加。土著居民的ASCVD比率不成比例,然而,高胆固醇血症对这一负担的影响程度尚不清楚.
■本研究旨在评估高胆固醇血症的患病率,严重的高胆固醇血症,和加拿大土著居民的家族性高胆固醇血症(FH),美国,澳大利亚,和新西兰。
■我们搜索了MEDLINE,EMBASE,WebofScience,本地健康数据库,Cochrane中央控制试验登记册,和Cochrane系统评价数据库,用于报告土著居民高胆固醇血症和LDL-C升高的同行评审研究。包括用于分类高胆固醇血症的所有诊断标准。使用随机效应模型计算合并患病率和95%CI。
■没有研究报告FH的患病率,有一项研究报告了土著人群中严重高胆固醇血症的患病率。使用LDL-C临界值≥3.5mmol/L(135mg/dL),高胆固醇血症的合并患病率为28.9%或〜1/3至1/4(95%CI:22.4%-36.4%)和12.6%(95%CI:7.7%-19.9%)。北美土著人口的合并患病率为24.3%(95%CI:17.1%-33.3%),而澳大利亚为40.0%(95%CI:31.3%-49.3%)。Meta回归显示糖尿病对患病率有显著影响(P=0.022)。
■高胆固醇血症在土著社区普遍存在,可能导致这些人群面临的ASCVD高负担。在世界各地的土著居民中,对FH和严重的高胆固醇血症的研究不足。
UNASSIGNED: Hypercholesterolemia is a common condition characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of atherosclerotic cardiovascular disease (ASCVD). Indigenous populations experience disproportionate rates of ASCVD, however, the extent to which hypercholesterolemia contributes to this burden is unknown.
UNASSIGNED: This study aimed to estimate the prevalence of hypercholesterolemia, severe hypercholesterolemia, and familial hypercholesterolemia (FH) in Indigenous populations in Canada, the United States, Australia, and New Zealand.
UNASSIGNED: We searched MEDLINE, EMBASE, Web of Science, Native Health Database, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews for peer-reviewed studies reporting on hypercholesterolemia and elevated LDL-C in Indigenous populations. All diagnostic criteria used to classify hypercholesterolemia were included. Pooled prevalence and 95% CIs were calculated using a random-effects model.
UNASSIGNED: There were no studies reporting the prevalence of FH and one study reporting the prevalence of severe hypercholesterolemia in Indigenous populations. The pooled prevalence of hypercholesterolemia was 28.9% or ∼1 in 3 to 1 in 4 individuals (95% CI: 22.4%-36.4%) and 12.6% (95% CI: 7.7%-19.9%) using an LDL-C cutoff of ≥3.5 mmol/L (135 mg/dL). The pooled prevalence in Indigenous populations in North America was 24.3% (95% CI: 17.1%-33.3%) compared with 40.0% (95% CI: 31.3%-49.3%) in Australia. Meta-regression showed diabetes had a significant effect on prevalence (P = 0.022).
UNASSIGNED: Hypercholesterolemia is prevalent in Indigenous communities and may contribute to the high burden of ASCVD these populations face. There is insufficient research on FH and severe hypercholesterolemia in Indigenous populations worldwide.