PDF(Pubmed)
Abstract：
The COVID-19 pandemic lockdowns affected the lifestyles of children and adolescents, leading to an increase in childhood obesity. Paediatric patients with familial hypercholesterolemia (FH) may be more susceptible to lockdown effects due to their increased cardiovascular risk. However, data are lacking. We investigated the effect of lockdowns on the metabolic profile of paediatric patients with FH. Blood lipids and anthropometry measured in September 2021-April 2022 were retrospectively compared with pre-pandemic values. Thirty participants were included (1-16 years; 57% female). From baseline to post-pandemic, median [P25, P75] blood LDL-C concentration was 125 [112, 150] mg/dL vs. 125 [100, 147] mg/dL (p = 0.894); HDL-C was 58 [52, 65] mg/dL vs. 56 [51, 61] mg/dL (p = 0.107); triglycerides were 64 [44, 86] mg/dL vs. 59 [42, 86] mg/dL (p = 0.178). The BMI z-score did not change significantly (0.19 [-0.58, 0.89] vs. 0.30 [-0.48, 1.10], p = 0.524). The lack of deterioration in metabolic profiles during lockdowns is positive, as some deterioration was expected. We speculate that patients and caregivers were successfully educated about healthy lifestyle and dietary habits. Our results should be interpreted with caution since the study sample was small and heterogeneous. Multicentre research is needed to better understand the impact of lockdowns on this population.
摘要：
COVID-19大流行的封锁影响了儿童和青少年的生活方式，导致儿童肥胖的增加。患有家族性高胆固醇血症（FH）的儿科患者由于心血管风险增加，可能更容易受到封锁作用的影响。然而,缺乏数据。我们调查了封锁对FH儿科患者代谢特征的影响。将2021年9月至2022年4月测量的血脂和人体测量学与大流行前值进行回顾性比较。包括30名参与者（1-16岁；57％为女性）。从基线到大流行后，中位[P25,P75]血LDL-C浓度为125[112,150]mg/dLvs.125[100,147]mg/dL（p=0.894）；HDL-C为58[52,65]mg/dLvs.56[51，61]mg/dL（p=0.107）；甘油三酯为64[44，86]mg/dLvs.59[42，86]mg/dL（p=0.178）。BMIz评分没有显着变化（0.19[-0.58，0.89]vs.0.30[-0.48,1.10],p=0.524)。封锁期间代谢状况没有恶化是积极的，正如预期的那样。我们推测患者和护理人员成功地接受了健康生活方式和饮食习惯的教育。我们的结果应谨慎解释，因为研究样本小且异质。需要进行多中心研究，以更好地了解封锁对这一人群的影响。
