■本研究旨在比较O-(2-18F-氟乙基)-1-酪氨酸(18F-FET)PET和2-脱氧-2-[18F]氟-d-脱氧葡萄糖(18F-FDG)PET对脊髓损伤的诊断功效。
■对疑似脊髓肿瘤的患者进行术前18F-FDGPET/MRI和18F-FETPET/MRI扫描。临床表现和PET表现,包括SUVmean,SUVmax,TBRmean,TBRmax,代谢性肿瘤体积(MTV),和总病变代谢(TLM),和肿瘤体积,使用组分析和受试者工作特征(ROC)曲线进行比较。
■根据病理诊断将35例患者分为三组:高级别肿瘤(HGTs,n=6),低度肿瘤(LGTs,n=19),和非肿瘤疾病(NTDs,n=10)。18F-FETPET的背景SUV均值显著低于18F-FDGPET(p<0.0001),而勾画的肿瘤体积无显著差异(p>0.05)。质量SUVmean,SUVmax,MTV,18F-FDGPET和18F-FETPET的TLM值在HGT和LGT之间有统计学差异(p<0.05)。同样,质量SUVmax,TBRmax,MTV,18F-FDGPET和18F-FETPET的TLM值,以及18F-FETPET的质量SUVmean,HGT和NTDs之间存在统计学差异(p<0.05)。但是没有一个能够区分LGT和NTDs(p>0.05)。值得注意的是,18F-FETPET为1例神经元-神经胶质混合性肿瘤(MNGT)和2例髓内炎性病变提供了有价值的辅助诊断证据。通过ROC分析确定用于区分肿瘤和NTDs的所有测量参数的最佳截断值。
■18F-FETPET在区分HGTs方面具有与18F-FDGPET相当的诊断性能,LGTs,和NTDs,但在MNGT和炎性病变中表现出特别的效用。
UNASSIGNED: This study aimed to compare the diagnostic efficacy of O-(2-18F-fluoroethyl)-l-tyrosine (18F-
FET) PET and 2-deoxy-2-[18F]fluoro-d-deoxyglucose (18F-FDG) PET for spinal cord lesions.
UNASSIGNED: Paired preoperative 18F-FDG PET/MRI and 18F-
FET PET/MRI scans were conducted on patients with suspected spinal cord tumors. Clinical manifestations and PET performance, including SUVmean, SUVmax, TBRmean, TBRmax, metabolic tumor volume (MTV), and total lesion metabolism (TLM), and tumor volume, were compared using group analysis and receiver operating characteristic (ROC) curves.
UNASSIGNED: Thirty-five patients were categorized into three groups based on their pathological diagnosis: high-grade tumors (HGTs, n = 6), low-grade tumors (LGTs, n = 19), and non-tumor diseases (NTDs, n = 10). The background SUVmean of 18F-
FET PET was significantly lower than that of 18F-FDG PET (p < 0.0001), while the delineated tumor volumes showed no significant difference (p > 0.05). The mass SUVmean, SUVmax, MTV, and TLM values of both 18F-FDG PET and 18F-
FET PET were statistically different between HGTs and LGTs (p < 0.05). Similarly, the mass SUVmax, TBRmax, MTV, and TLM values of both 18F-FDG PET and 18F-
FET PET, as well as the mass SUVmean of 18F-FET PET, exhibited statistical differences between HGTs and NTDs (p < 0.05). But none were able to distinguish LGTs and NTDs (p > 0.05). Notably, 18F-FET PET provided valuable supporting diagnostic evidence in 1 case of mixed neuronal-glial tumor (MNGT) and 2 cases of intramedullary inflammatory lesions. Optimal cut-off values of all measured parameters for distinguishing tumors and NTDs were determined through ROC analysis.
UNASSIGNED: 18F-FET PET presented comparable diagnostic performance to 18F-FDG PET in differentiating HGTs, LGTs, and NTDs, but exhibited particular utility in MNGT and inflammatory lesions.