在这项研究中,具有恒定表面积的3D打印片剂是在外部隔室中使用聚乳酸(PLA)和在内部隔室中使用聚乙烯醇和非洛地平(FDP)设计和制造的。内隔室不同表面几何形状的影响,即,圆形,六边形,正方形,和三角形,还研究了3D打印片剂的药物释放。利用扫描电子显微镜和同步辐射X射线断层显微镜测定内室的形态和孔隙率,分别。此外,还评估了药物含量和药物释放。结果表明,圆形几何形状似乎具有最大的内隔室的总表面积,其次是方形,六边形,和三角形的几何形状。具有三角形和六边形表面几何形状的FDP装载的3D打印片剂具有最慢的药物释放(24小时内约80%)。在圆形和方形的3D打印药片中,在12小时内观察到药物完全释放。此外,从内部隔室体积两倍的三角形3D打印片剂中的药物释放比较小体积的更快。这是由于较大的片剂体积增加了接触介质的表面积。导致更快的药物释放。研究结果表明,具有恒定表面积的3D打印片剂的表面几何形状影响药物释放。这项研究表明,3D打印技术可用于开发适合定制治疗的口服固体剂型。
In this study, 3D-printed tablets with a constant surface area were designed and fabricated using polylactic acid (PLA) in the outer compartment and polyvinyl alcohol and felodipine (FDP) in the inner compartment. The influences of different surface geometries of the inner compartment, namely, round, hexagon, square, and triangle, on drug release from 3D-printed tablets were also studied. The morphology and porosity of the inner compartment were determined using scanning electron microscopy and synchrotron radiation X-ray tomographic microscopy, respectively. Additionally, drug content and drug release were also evaluated. The results revealed that the round-shaped geometry seemed to have the greatest total surface area of the inner compartment, followed by square-shaped, hexagon-shaped, and triangle-shaped geometries. FDP-loaded 3D-printed tablets with triangle and hexagon surface geometries had the slowest drug release (about 80% within 24 h). In the round-shaped and square-shaped 3D-printed tablets, complete drug release was observed within 12 h. Furthermore, the drug release from triangle-shaped 3D-printed tablets with double the volume of the inner compartment was faster than that of a smaller volume. This was due to the fact that a larger tablet volume increased the surface area contacting the medium, resulting in a faster drug release. The findings indicated that the surface geometry of 3D-printed tablets with a constant surface area affected drug release. This study suggests that 3D printing technology may be used to develop oral solid dosage forms suitable for customized therapeutic treatments.