PDF(Pubmed)
Abstract：
Microneedles (MNs) have emerged as an innovative, virtually painless technique for intradermal drug delivery. However, the complex and costly fabrication process has limited their widespread accessibility, especially for individuals requiring frequent drug administration. This study introduces a groundbreaking and cost-effective method for producing MNs utilizing fused deposition modeling (FDM) 3D printing technology to enhance transdermal drug delivery. The proposed fabrication process involves the elongation of molten polylactic acid (PLA) filaments to create meticulously designed conoid and neiloid MNs with smooth surfaces. This study underscores the critical role of printing parameters, particularly extrusion length and printing speed, in determining the shape of the MNs. Notably, the conoid-shaped MNs exhibit exceptional skin-penetrating capabilities. In order to evaluate their effectiveness, the MNs were tested on a polydimethylsiloxane (PDMS) skin model for skin penetration. The results highlight the high potential of 3D-printed MNs for transdermal drug administration. This novel approach capitalizes on the benefits of 3D printing technology to fabricate MNs that hold the promise of transforming painless drug administration for a variety of medical applications.
摘要：
微针(MNs)已经成为一种创新，皮内药物递送的几乎无痛技术。然而,复杂而昂贵的制造过程限制了它们的广泛可及性，特别是对于需要频繁给药的个人。这项研究介绍了一种利用熔融沉积建模（FDM）3D打印技术来增强经皮药物递送的开创性和经济有效的方法。所提出的制造工艺涉及熔融聚乳酸(PLA)长丝的伸长,以产生具有光滑表面的精心设计的锥形和neiloidMNs。这项研究强调了印刷参数的关键作用，特别是挤出长度和印刷速度，在确定MN的形状时。值得注意的是,圆锥形的MNs表现出特殊的皮肤穿透能力。为了评估其有效性，在聚二甲基硅氧烷(PDMS)皮肤模型上测试MN的皮肤渗透。结果突出了3D打印的MNs用于透皮给药的高潜力。这种新颖的方法利用3D打印技术的优势来制造MN，这些MN有望将无痛药物管理转变为各种医疗应用。
