目标:我们评估了健康饮食模式[替代地中海饮食(aMED),停止高血压(DASH)的饮食方法替代健康饮食指数(AHEI),和健康饮食指数2015(HEI-2015)]和氧化应激的尿液生物标志物。
方法:在2003年至2009年之间,姐妹研究招募了50,884名年龄在35至74岁之间的无乳腺癌美国女性(非西班牙裔白人,83.7%)。分析了844名绝经前和454名绝经后妇女的数据,这些妇女的尿液样本分析了F2-异前列腺素和非缺失的协变量数据。食物频率问卷回答用于计算饮食模式得分。通过GC/MS对绝经前妇女和LC/MS对绝经后妇女测量尿液样品中8-异-前列腺素F2α(8-异-PGF2α)及其代谢物(8-异-PGF2α-M)的浓度。多变量线性回归模型用于估计AMED,DASH,aHEI,和HEI-2015和尿F2-异前列腺素的绝经状态。社会人口统计学效应修正,生活方式,并对临床特征进行了评估.
结果:在绝经前妇女中,4种膳食指数与8-iso-PGF2α呈负相关(aMEDβQ4vsQ1:-0.17,95%CI-0.27,-0.08;DASHβQ4vsQ1:-0.18,95%CI-0.28,-0.08;aHEIβQ4vsQ1:-0.20,95%CI-0.30,-0.10;HEI-2015,Q4vs19-0.29-95相比之下,对于连续的aMED,发现了与8-iso-PGF2α-M的逆关联,aHEI,HEI-2015饮食指数和8-iso-PGF2α之间的关联在年轻女性中普遍更强,收入较低的妇女,BMI较高的女性。在绝经后妇女中观察到类似的结果,尽管只有连续DASH和aHEI模型有统计学意义。
结论:健康的膳食模式与较低的氧化应激水平相关。
OBJECTIVE: We assessed the cross-sectional association between healthy dietary patterns [alternate Mediterranean diet (aMED), Dietary Approaches to Stop Hypertension (DASH), alternative Healthy Eating Index (aHEI), and Healthy Eating Index 2015 (HEI-2015)] and urinary biomarkers of oxidative stress.
METHODS: Between 2003 and 2009, the Sister Study enrolled 50,884 breast cancer-free US women aged 35 to 74 (non-Hispanic White, 83.7%). Data were analyzed for 844 premenopausal and 454 postmenopausal women who had urine samples analyzed for F2-isoprostanes and non-missing covariate data. Food frequency questionnaire responses were used to calculate dietary pattern scores. Concentrations of 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite (8-iso-PGF2α-M) were measured in urine samples by GC/MS for premenopausal women and LC/MS for postmenopausal women. Multivariable linear regression models were used to estimate associations between aMED, DASH, aHEI, and HEI-2015 and urinary F2-isoprostanes by menopausal status. Effect modification by sociodemographic, lifestyle, and clinical characteristics was also evaluated.
RESULTS: Among premenopausal women, the four dietary indices were inversely associated with 8-iso-PGF2α (aMED βQ4vsQ1: - 0.17, 95% CI - 0.27, - 0.08; DASH βQ4vsQ1: - 0.18, 95% CI - 0.28, - 0.08; aHEI βQ4vsQ1: - 0.20, 95% CI - 0.30, - 0.10; HEI-2015 βQ4vsQ1: - 0.19, 95% CI - 0.29, - 0.10). In contrast, inverse associations with 8-iso-PGF2α-M were found for the continuous aMED, aHEI, and HEI-2015. Associations between dietary indices and 8-iso-PGF2α were generally stronger among younger women, women with lower income, and women with higher BMI. Similar results were observed among postmenopausal women, though only the continuous DASH and aHEI models were statistically significant.
CONCLUSIONS: Healthy dietary patterns were associated with lower levels of oxidative stress.