背景:Elsholtzia属(唇科)是民间传统中药的重要来源,主要用于缓解感冒症状,发烧,肺炎等等。然而,关于其传统和药理优势的现有数据尚未得到全面审查。
目的:这篇综述提供了关于民族药理学的最新和全面的信息,植物化学,Elsholtzia的药理特性和毒性,突出了抗菌,抗病毒,和该属的抗炎优势,并探索其治疗潜力。
方法:使用谷歌学者,Scifinder,PubMed,Springer,Elsevier,威利,WebofScience和其他在线数据库搜索,收集有关应用的研究文献,2021年12月之前发表的Elsholtzia的化学和生物活性。他们的学名已通过《植物名录》和《世界植物区系在线》网站进行了验证。
结果:共有42种Elsholtzia广泛分布于世界各地,尤其是在中国云南省。由于Elsholtzia属在民间常用于治疗感冒和发烧等呼吸道传染病,越来越多的研究证实了它们的抗病毒作用,抗菌和抗炎活性。到目前为止,已从Elsholtzia植物中鉴定出大约221种非挥发性化合物和1008种挥发性化合物,主要含有显示令人信服的抗菌类黄酮和萜类化合物,抗病毒和抗炎活性。进一步研究发现,它们的抗菌和抗病毒谱广泛,和挥发油被认为是主要的抗菌成分。其抗炎机制主要是通过抑制NF-κB和MAPKs信号通路。毒理学研究尚未确定其毒性。
结论:通过总结有关Elsholtzia属的最新信息,他们的传统用途,抗病毒的物质基础和作用机制,抗菌和抗炎方面进行了描述,为该属及其作为抗病毒和抗炎药的潜在自然资源的重要性提供了新的见解,为草药的发展提供证据和新思路。
BACKGROUND: The genus
Elsholtzia (family Labiaceae) is an important source of folk traditional Chinese medicine, mainly used to relieve the symptoms of cold, fever, pneumonia and so on. However, currently available data on its traditional and pharmacological advantages have not been comprehensively reviewed.
OBJECTIVE: This review provides up-to-date and comprehensive information on the ethnopharmacological, phytochemical, pharmacological properties and toxicity of
Elsholtzia, highlights the antibacterial, antiviral, and anti-inflammatory advantages of the genus, and explores its therapeutic potential.
METHODS: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the research literatures on application, chemistry and biological activity of Elsholtzia published before December 2021. Their scientific names have been verified using The Plant List and World Flora Online websites.
RESULTS: A total of 42 species of Elsholtzia are widely distributed all over the world, especially in Yunnan Province (China). Since
Elsholtzia genus is commonly used in the folk to treat respiratory infectious diseases such as cold and fever, growing numbers of studies have confirmed their antiviral, antibacterial and anti-inflammatory activities. So far, about 221 non-volatile compounds and 1008 volatile compounds have been identified from
Elsholtzia plants, mainly containing flavonoids and terpenoids showing convincing antibacterial, antiviral and anti-inflammatory activities. Further research found that their antibacterial and antiviral spectrums are broad, and volatile oils are considered to be the main antibacterial components. Their anti-inflammatory mechanism is mainly through the inhibition of NF-κB and MAPKs signaling pathways. Toxicological studies have not established its toxicity.
CONCLUSIONS: By summarizing the latest information on genus
Elsholtzia, their traditional uses, material basis and mechanisms of action in antiviral, antibacterial and anti-inflammatory aspects were described, providing new insights for the genus and its importance as a potential natural resource of antiviral and anti-inflammatory drugs, giving evidence and new ideas for the development of herbal medicines.