■双氯芬酸(DCF)是一种具有镇痛和解热特性的非甾体抗炎药。它用于治疗类风湿性关节炎疼痛,骨关节炎,和急性肌肉疼痛的情况下,可以口服给药,局部或静脉内。由于它的广泛使用,亲水性,稳定性和降解不良(食物链中的生物积累),DCF是一种新兴的化学污染物,可对生态系统造成不利影响。考虑到药物制剂中DCF的消耗及其对环境的负面影响,新敏感的发展,选择性,便宜,快,现场应用需要具有在线能力的分析设备。
■这篇简短的评论试图涵盖与使用纳米材料作为电化学测定药物制剂中DCF的催化剂有关的最新进展,生物流体和环境样品。
■本文旨在证明电化学传感器如何代表DCF分析的常规方法的可靠替代品。
■手稿重点介绍了用于DCF检测的电化学传感器的开发进展。我们分析了许多最近的论文(主要是自2019年以来)关于为定量测定DCF而开发的传感器,指示检测极限,线性范围,稳定性,再现性,和分析应用。概述了与传感器设计和未来前景相关的当前挑战。
UNASSIGNED: Diclofenac (DCF) is a non-steroidal anti-inflammatory drug possessing analgesic and antipyretic properties. It is used for the treatment of rheumatoid arthritis pain, osteoarthritis, and acute muscle pain conditions and can be administrated orally, topically or intravenously. Because of its widespread use, hydrophilicity, stability and poor degradation (bioaccumulation in the food chain), DCF is an emerging chemical contaminant that can cause adverse effects in the ecosystems. Taking into account the consumption of DCF in pharmaceutical formulations and its negative impact on the environment, the development of new sensitive, selective, cheap, fast, and online capable analytical devices is needed for on-site applications.
UNASSIGNED: This brief review attempts to cover the recent developments related to the use of nanomaterials as catalysts for electrochemical determination of DCF in pharmaceutical formulations, biological fluids and environmental samples.
UNASSIGNED: The article aims to prove how electrochemical sensors represent reliable alternatives to conventional methods for DCF analysis.
UNASSIGNED: The manuscript highlights the progress in the development of electrochemical sensors for DCF detection. We have analyzed numerous recent papers (mainly since 2019) on sensors developed for the quantitative determination of DCF, indicating the limit of detection, linear range, stability, reproducibility, and analytical applications. Current challenges related to the sensor design and future perspectives are outlined.