目标:环境化学物质暴露可能会破坏儿童发育,具有持久的健康影响。迄今为止,美国对早期环境暴露的研究在规模和多样性方面受到限制,阻碍权力和普遍性。根据来自60,000多名参与者的统一数据,代表69个怀孕队列,美国国立卫生研究院的环境对儿童健康结果的影响(ECHO)计划是美国最大的儿童健康研究。这里,我们:(1)回顾ECHO范围内的化学品暴露和母婴健康研究;(2)概述使用ECHO数据进行未来研究的机会.
结果:截至2024年初,除了由ECHO支持的200多篇关于化学暴露的单组(或奖励)论文外,通过ECHO数据协调和新的数据收集,十篇协作多队列论文成为可能。多队列论文检查了产前暴露于全氟烷基和多氟烷基物质(PFAS),邻苯二甲酸酯,酚类和对羟基苯甲酸酯,有机磷酸酯(OPEs),金属,三聚氰胺和芳香胺,和新兴的污染物。他们主要集中在描述母亲暴露的模式或检查与母亲和婴儿结局的关联;较少的研究检查了以后的儿童结局(例如,自闭症),尽管对注册的ECHO儿童的随访仍在继续。NICHD的数据和样本中心(DASH)数据库包含广泛的ECHO数据,包括超过470,000个化学分析结果和优先结果领域的补充数据(前,pery-,产后,气道,肥胖,神经发育,和积极的健康),使其成为未来分析的丰富资源。ECHO的广泛的数据存储库,包括化学暴露的生物标志物,可以用来提高我们对环境对儿童健康影响的认识。尽管迄今为止很少有发表的研究利用这些独特的协调数据,许多分析正在进行中,数据现已广泛可用。
OBJECTIVE: Environmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early environmental exposures have been limited in size and diversity, hindering power and generalizability. With harmonized data from over 60,000 participants representing 69 pregnancy cohorts, the National Institutes of Health\'s Environmental influences on Child Health Outcomes (ECHO) Program is the largest study of U.S. children\'s health. Here, we: (1) review
ECHO-wide studies of chemical exposures and maternal-child health; and (2) outline opportunities for future research using
ECHO data.
RESULTS: As of early 2024, in addition to over 200 single-cohort (or award) papers on chemical exposures supported by ECHO, ten collaborative multi-cohort papers have been made possible by
ECHO data harmonization and new data collection. Multi-cohort papers have examined prenatal exposure to per- and polyfluoroalkyl substances (PFAS), phthalates, phenols and parabens, organophosphate esters (OPEs), metals, melamine and aromatic amines, and emerging contaminants. They have primarily focused on describing patterns of maternal exposure or examining associations with maternal and infant outcomes; fewer studies have examined later child outcomes (e.g., autism) although follow up of enrolled ECHO children continues. The NICHD\'s Data and Specimen Hub (DASH) database houses extensive
ECHO data including over 470,000 chemical assay results and complementary data on priority outcome areas (pre, peri-, and postnatal, airway, obesity, neurodevelopment, and positive health), making it a rich resource for future analyses.
ECHO\'s extensive data repository, including biomarkers of chemical exposures, can be used to advance our understanding of environmental influences on children\'s health. Although few published studies have capitalized on these unique harmonized data to date, many analyses are underway with data now widely available.