未经证实:描述64例特发性声门下狭窄(iSGS)患者的治疗途径和长期结局,包括连续病灶内类固醇注射(SILSI)对狭窄程度的影响,需要后续操作,和患者报告的结果指标。
UNASSIGNED:回顾性回顾64例接受多种管理方法的iSGS女性患者,其中57人接受了SILI作为他们护理的至少一部分。治疗途径仅包括SILSI,仅在SILI之后进行内窥镜干预,仅内镜干预,内窥镜介入,然后是SILSI,然后需要重复内窥镜介入,开放手术,和气管切开术.评估的结果包括主观估计的气道狭窄百分比,呼吸困难指数(DI),改良医学研究委员会(MMRC)呼吸困难量表,语音障碍指数-10(VHI-10),执行的手术和基于办公室的程序的数量,需要后续手术干预,和手术间隔。
未经评估:治疗途径包括单独的SILI(n=6),仅在SILI之后进行内窥镜干预(n=31),SILSI随后是额外的内窥镜或基于办公室的程序(n=16),开放手术(n=3),气管造口术(n=4)。64例患者中的57例接受了SILI作为其治疗的至少一部分。开始SILSI后,手术间隔增加。在接受SILI治疗的患者中,在SILSI之前手术次数较多或手术间隔时间较短的患者更有可能返回手术室.估计狭窄,DI,MMRC,VHI-10随SILI而下降。狭窄与DI无关,MMRC,或VHI-10,尽管DI与MMRC和VHI-10评分相关。
未经批准:57名接受SILI的患者,37不需要进一步的手术干预。手术间隔的改善,呼吸困难,在患者中观察到声音。有必要进行随机试验,以确定哪些患者可能从SILSI中受益最大。
UNASSIGNED: To describe treatment pathways and long-term outcomes in 64 patients with idiopathic subglottic stenosis (iSGS), including the impact of serial intralesional steroid injection (SILSI) on degree of stenosis, need for subsequent operation, and patient-reported outcome measures.
UNASSIGNED: Retrospective review of 64 female patients with iSGS undergoing varied management approaches, 57 of whom underwent SILSI as at least part of their care. Treatment pathways included SILSI only, endoscopic intervention followed by SILSI only, endoscopic interventions only, endoscopic intervention followed by SILSI followed by need for repeat endoscopic intervention, open surgery, and tracheotomy. Outcomes assessed included subjectively estimated percent airway stenosis, dyspnea index (DI), modified medical research council (MMRC) dyspnea scale, voice handicap index-10 (VHI-10), number of operative and office-based procedures performed, need for subsequent operative intervention, and inter-operative interval.
UNASSIGNED: Treatment pathways included SILSI alone (n = 6), endoscopic intervention(s) followed by SILSI only (n = 31), SILSI followed by additional endoscopic or office-based procedures (n = 16), open surgery (n = 3), and tracheostomy (n = 4). 57 of 64 patients underwent SILSI as at least part of their treatment. Inter-operative interval was increased after starting SILSI. Of patients undergoing SILSI, those with more procedures or shorter inter-operative interval prior to SILSI were more likely to return to the operating room. Estimated stenosis, DI, MMRC, and VHI-10 decreased with SILSI. Stenosis was not correlated with DI, MMRC, or VHI-10, though DI was correlated with both MMRC and VHI-10 score.
UNASSIGNED: Of 57 patients undergoing SILSI, 37 did not require further operative intervention. Improvements in inter-operative interval, dyspnea, and voice were observed across patients. Randomized trials to identify which patients may benefit most from SILSI are warranted.