■要调查人口统计特征,主要内镜检查结果,和幽门螺杆菌(H.pylori)在桑给巴尔群岛接受上消化道内窥镜检查(UGIE)的入选受试者的感染,坦桑尼亚。
■在2013年12月至2021年10月期间,本回顾性队列中最终招募了3146名符合条件的参与者。检索每个参与者的人口统计信息和内窥镜检查结果。幽门螺杆菌感染通过胃窦和体部活检的快速尿素酶试验得到证实。
■在招募的科目中,1691(53.76%)是女性,其余1455人(46.24%)为男性。该回顾性队列的中位年龄为40岁,范围为8至97岁。常见的内镜检查结果包括胃十二指肠炎,正常的内镜检查,消化性溃疡病(PUD),食管炎,食管胃静脉曲张,食管癌和胃癌,分别。在调整了性别和年龄后,胃和/或十二指肠溃疡的显著风险(OR,2.51;95%CI,1.82-3.48,P<0.001)和胃癌(OR,在幽门螺杆菌阳性组中观察到3.49;95%CI,1.27-9.58,P=0.015)。分层分析表明十二指肠溃疡与年龄较小之间存在显着关系(调整后的OR,0.98;95%CI,0.97-0.99,p=0.002),和幽门螺杆菌的存在(OR,2.01;95%CI,1.12-3.91,p=0.021)。
■本研究显示胃十二指肠炎,PUD,和正常的发现是桑给巴尔最常见的内镜诊断。幽门螺杆菌的存在与十二指肠溃疡和胃癌显著相关。
UNASSIGNED: To investigate the demographic features, primary endoscopic findings, and the status of Helicobacter Pylori (H. pylori) infection of the enrolled subjects who underwent upper gastrointestinal endoscopy (UGIE) in the Zanzibar Archipelago, Tanzania.
UNASSIGNED: Between December 2013 and October 2021, a total of 3146 eligible participants were finally recruited in present retrospective cohort. Demographic information and endoscopic findings of each participant was retrieved. H. pylori infection was confirmed by rapid-urease test of gastric antral and body biopsies at endoscopy.
UNASSIGNED: Among the recruited subjects, 1691 (53.76%) are females, remaining 1455 (46.24%) are males. The median age of this retrospective cohort was 40 years ranging from 8 to 97 years. The common identified endoscopic findings included gastro-
duodenitis, normal endoscopic finding, peptic ulcer disease (PUD), esophagitis, esophagogastric varices, esophageal and gastric cancer, respectively. After adjustment for sex and age, a significant risk of gastric and/or duodenal ulcer (OR, 2.51; 95% CI, 1.82-3.48, P<0.001) and gastric cancer (OR, 3.49; 95% CI, 1.27-9.58, P=0.015) in H. pylori positive group was observed. Stratified analysis indicated a significant relationship between duodenal ulcer with younger age (adjusted OR, 0.98; 95% CI, 0.97-0.99, p = 0.002), and the presence of H. pylori (OR, 2.01; 95% CI, 1.12-3.91, p= 0.021).
UNASSIGNED: The present study revealed that gastro-
duodenitis, PUD, and normal finding are the most common endoscopic diagnoses in Zanzibar. The presence of H. pylori is significantly associated with duodenal ulcer and gastric cancer.