背景:语用学是可以在多种疾病中受到影响的领域。在这个意义上,综合征自闭症被定义为在相关综合征和自闭症谱系障碍(ASD)之间建立因果关系的疾病。同样,唐氏综合症(DS)是主要的基于遗传的综合症之一,其中ASD被描述为其可能的表现之一。在这个方向上,患有DS的人被描述为社会存在,而在ASD中,这个领域似乎有一个特定的改变。
方法:在本研究中,在72名参与者的样本中分析了语用表现,其中比较了ASD儿童(n=24)获得的分数,DS(n=24)和DS+ASD(n=24)。
结果:社会交往问卷(SCQ),针对心理理论(ToM)的块目标和标准语言电池(BLOC-SR)和神经心理学子测试(NEPSY-II)确定了两组之间的显着差异。然而,两两比较报告DS和DS+ASD之间没有显著差异。
结论:尽管一些研究报告了三个提议组之间的差异,我们的数据似乎表明,DS患者的ASD症状与智力发育障碍(IDD)相关.然而,缺乏关于共病诊断的可靠科学证据使得沿着这些路线进行进一步的研究是不可或缺的。
背景:本研究由UCLM社会研究伦理委员会批准,参考CEIS-704,511-L8M4。
BACKGROUND: Pragmatics is an area that can be affected in a wide variety of disorders. In this sense, Syndromic Autism is defined as a disorder in which a causal link is established between an associated syndrome and Autism Spectrum Disorder (ASD). Likewise, Down Syndrome (DS) is one of the main genetically based syndromes in which ASD is described as one of its possible manifestations. In this direction, people with DS are described as social beings whereas in ASD there seems to be a specific alteration of this domain.
METHODS: In this study, pragmatic performance was analysed in a sample of 72 participants, where comparisons were made between the scores obtained by children with ASD (n = 24), with DS (n = 24) and with DS + ASD (n = 24).
RESULTS: The Social Communication Questionnaire (SCQ), the Block Objective and Criterial Language Battery (BLOC-SR) and the Neuropsychology subtest (NEPSY-II) aimed at Theory of Mind (ToM) identified significant differences between the groups. However, two-to-two comparisons reported no significant differences between DS and DS + ASD.
CONCLUSIONS: Although several studies report differences between the three proposed groups, our data seem to suggest that ASD symptomatology in DS is associated with Intellectual Developmental Disorder (IDD). However, the lack of solid scientific evidence regarding comorbid diagnosis makes further research along these lines indispensable.
BACKGROUND: This study was approved by the Ethics Committee for Social Research at UCLM with reference CEIS-704,511-L8M4.