背景:代谢灵活性(MetF),定义为在脂肪和葡萄糖氧化之间转换的能力,越来越被认为是评估对饮食干预反应的关键指标。以前,我们发现食用多纤维面包可改善超重和肥胖个体的胰岛素敏感性并降低低密度脂蛋白胆固醇(LDLc)水平.作为次要目标,我们的目的是探讨我们的干预是否也能改善MetF.
方法:在本研究中,39名处于心脏代谢风险的受试者参加了双盲,随机化,交叉试验持续8周,重复两次。在每个阶段,参与者每天食用150克标准面包或富含七种膳食纤维混合物的面包。使用混合餐耐量试验(MMTT)评估MetF反应,分析使用间接量热法测量的呼吸商(ΔRQ)的变化。
结果:尽管两种饮食中膳食纤维引起的ΔRQ变化没有显着差异,这些变化与基线时的餐后甘油三酯漂移(ΔTG)呈正相关.进行基线空腹和餐后血浆代谢物的亚组分析以表征MetF应答者。这些反应者表现出更高的基线空腹LDLc水平和更高的MMTT后TG。
结论:结论:虽然膳食纤维在这项研究中没有直接影响MetF,我们的发现强调了MetF反应的潜在决定因素,保证在未来的专门干预措施中进行进一步调查。
BACKGROUND: Metabolic flexibility (MetF), defined as the ability to switch between fat and glucose oxidation, is increasingly recognised as a critical marker for assessing responses to dietary interventions. Previously, we showed that the consumption of multifibre bread improved insulin sensitivity and reduced low-density lipoprotein cholesterol (LDLc) levels in overweight and obese individuals. As a secondary objective, we aimed to explore whether our intervention could also improve MetF.
METHODS: In this study, 39 subjects at cardiometabolic risk participated in a double-blind, randomised, crossover trial lasting 8 weeks, repeated twice. During each phase, participants consumed either 150 g of standard bread daily or bread enriched with a mixture of seven dietary fibres. MetF response was assessed using a mixed-meal tolerance test (MMTT), analysing changes in respiratory quotient (∆RQ) measured using indirect calorimetry.
RESULTS: Although there were no significant differences in ∆RQ changes induced by dietary fibre between the two diets, these changes were positively correlated with postprandial triglyceride excursion (∆TG) at baseline. Subgroup analysis of baseline fasting and postprandial plasma metabolites was conducted to characterise MetF responders. These responders exhibited higher baseline fasting LDLc levels and greater post-MMTT ∆TG.
CONCLUSIONS: In conclusion, although dietary fibres did not directly impact MetF in this study, our findings highlight potential determinants of MetF response, warranting further investigation in dedicated future interventions.