Depressive disorders

抑郁症
  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    目的:病理性妊娠妇女是一类特别容易发生心理并发症的患者。这项研究的目的是评估抑郁症和焦虑症的风险,症状强度与社会支持的关系。
    方法:研究组为妊娠病理科住院患者300例。这项研究是使用状态特质焦虑量表(STAI)进行的,医院焦虑和抑郁量表(HADS),社会支持行为清单(ISSB),和作者构建的社会人口统计问卷。
    结果:研究组受访者的状态焦虑(STAI)水平更高,与对照组相比。对照组的焦虑水平(HADS-A)高于研究组的女性。对照组的社会信息支持水平较高,与研究组相比。研究组受访者的情绪支持水平较低,与对照组相比。仪器支持与生理妊娠妇女的抑郁症状呈负相关。在分娩前住院的妇女中,缺乏评估支持与焦虑显着相关。
    结论:所获得的结果表明,有必要为妊娠病理科雇用的医疗和心理人员进行实质性准备,为住院妇女提供适当的情感和信息支持。
    OBJECTIVE: Women in pathological pregnancy are a group of patients especially exposed to the risk of occurrence of psychological complications. The aim of the study was assessment of the risk of depressive and anxiety disorders, and the relationship between the intensity of symptoms and social support.
    METHODS: The study group were 300 patients hospitalized in the Department of Pathology of Pregnancy. The study was conducted using the State-Trait Anxiety Inventory (STAI), the Hospital Anxiety and Depression Scale (HADS), the Inventory of Socially Supportive Behaviours (ISSB), and an author-constructed socio-demographic questionnaire.
    RESULTS: The level of State Anxiety (STAI) was higher in respondents from the study group, compared to the control group. The level of anxiety (HADS-A) was higher in the control group than in women from the study group. The level of social informational support was higher in those from the control group, compared to those from the study group. The level of emotional support was lower in respondents from the study group, compared to those from the control group. Instrumental support negatively correlated with the symptoms of depression among women in physiological pregnancy. The lack of evaluative support statistically significantly correlated with anxiety among women hospitalized before labour.
    CONCLUSIONS: The results obtained suggest the necessity for the substantive preparation of medical and psychological staff employed in departments of pathology of pregnancy to provide proper emotional and informational support for hospitalized women.
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    文章类型: Journal Article
    不到三十年前,抑郁症被认为是一种主要的成人疾病,因为儿童被认为在发育上太不成熟,无法经历抑郁症。青少年情绪低落被认为是青少年情绪波动的一部分。儿童和青少年的重度抑郁症是一种严重的精神疾病,尤其是在儿科手术患者中。这可能是由于他们的代谢率改变,并提高了对创伤的代谢反应,这对儿童的心理发育具有重要意义。然而,它仍然被低估和对待。护理人员的福祉也没有被忽视,因为护理人员被淹没在为医院护理寻找和提供资金的任务中。,除了为病人提供护理的压力。这可能会导致工时损失,失眠,以及与照顾这些患病儿童相关的身体疲惫,这最终会显著增加他们抑郁发作的风险。本评论的目的是强调以下事实:儿科手术患者不能免于患有严重抑郁症,并且在病房入院期间也应对护理人员进行评估。
    这是对尼日利亚儿科手术患者抑郁症的评论。使用以下领域搜索了有关儿童和青少年到医院就诊的相关出版物:尼日利亚青少年的抑郁症,PubMed上的儿科手术患者,谷歌学者,和MEDLINE来评估这次审查。
    情绪失调,在过去的二十年中,对儿童和青少年的抑郁症的研究越来越多,手术条件恶化了前景,最终增加了对演示文稿的了解,和治疗。尽管如此,它仍然经常被错过或误诊,因为它有时会出现不典型的症状。在尼日利亚患者中,儿科手术患者的抑郁症患病率在46-82%之间。
    UNASSIGNED: Less than three decades ago, depression was seen as a predominantly adult disorder as children were considered too developmentally immature to experience depressive disorders, and adolescent low mood was considered as part of \'normal\' teenage mood swings. Major depressive disorder in children and adolescents is a serious psychiatric illness especially in paediatric surgical patients. This may be due to their altered metabolic rate and heighten metabolic response to trauma which has significant implications for the psychological development of the child, yet it remains under-recognized and undertreated. The well-being of the care givers is also not left out as the care givers are inundated with the task of sourcing and providing finance for hospital care., in addition to the stress of providing care for the patient. This may result in loss of man hour, sleeplessness, and physical exhaustion associated with caring for these ill children which can ultimately significantly increase the risk of them having depressive episode. The aim of this commentary is to highlight the fact that paediatric surgical patients are not exempt to having a major depressive disorder and the care givers should also be evaluated during hospital admission of their wards.
    UNASSIGNED: This is a commentary on depressive disorders among Nigerian paediatric surgical patients. Related publications on children and adolescents presenting to hospital were searched using the domain - Depression in Nigerian adolescent, Paediatric surgery patients on PubMed, Google Scholar, and MEDLINE to appraise this review.
    UNASSIGNED: Mood disorders, especially depression in children and adolescents have been studied increasingly over the last two decades and surgical conditions worsen the outlook, culminating in increased knowledge about the presentation, and treatment. Despite this, it is still often missed or misdiagnosed because it sometimes presents with uncharacteristic symptoms. Prevalence of depressiion among paediatric surgical patient were found to be between 46-82% in this review among Nigerian patients.
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  • 文章类型: Journal Article
    目的:成人研究表明,侵入性记忆和侵入性思维(通常称为侵入性认知)在普通人群中很常见,并且在临床疾病中也很常见。然而,关于青少年侵入性认知的经历知之甚少,特别是在患有重度抑郁症(MDD)和创伤后应激障碍(PTSD)的青少年中。本研究试图收集有关这些现象的基本数据(即,频率,患有MDD和PTSD的青少年的侵入性认知的特征和评估)。
    方法:11-18岁青少年MDD(n=11),PTSD(n=13)和非临床对照组(n=25)完成了有关其侵入性记忆和思想的结构化访谈。
    结果:侵入性思维在所有三组中都很常见,但在MDD组中尤其常见。侵入性记忆在PTSD组中非常普遍,但超过一半的MDD青少年也经历过。与非临床组相比,两个临床组都报告了更多的负面情绪来回应他们的侵入性思想或记忆,并且对这些认知的评价更加负面。
    结论:侵入性记忆和思想是患有MDD和PTSD的青少年的常见经历。与这些认知相关的情绪和评估可能是该年龄段心理干预的目标。然而,小样本量限制了可以得出的结论。大量临床参与者需要复制。
    OBJECTIVE: Research in adults suggests that intrusive memories and intrusive thoughts (often referred to as intrusive cognitions) are common in members of the general population and are often seen in clinical disorders. However, little is known about the experience of intrusive cognitions in adolescents, particularly in adolescents with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The present study sought to gather fundamental data on these phenomena (i.e., frequency, characteristics and appraisals of intrusive cognitions) in adolescents with MDD and PTSD.
    METHODS: Adolescents aged 11-18 with MDD (n = 11), PTSD (n = 13) and a non-clinical control group (n = 25) completed structured interviews concerning their intrusive memories and thoughts.
    RESULTS: Intrusive thoughts were common in all three groups but were particularly frequently experienced in the MDD group. Intrusive memories were expectedly very common in the PTSD group but also experienced by over half of the adolescents with MDD. Both clinical groups reported more negative emotions in response to their intrusive thoughts or memories and appraised these cognitions more negatively than the non-clinical group.
    CONCLUSIONS: Intrusive memories and thoughts are common experiences in adolescents with MDD and PTSD. Emotions and appraisals relating to these cognitions may be targets for psychological intervention in this age group. However, small sample sizes limit the conclusions that can be drawn. Replication is needed with larger numbers of clinical participants.
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  • 文章类型: Journal Article
    抑郁症是世界范围内日益严重的问题。它们的特征还在于高合并症,包括来自皮肤病的圈子。自身免疫性疾病似乎与抑郁共病特别相关,提出了他们可能的共同病理机制的问题。搜索了PubMed数据库,关注2016年后公布的结果。抑郁症与牛皮癣的特定相互关系,特应性皮炎,斑秃,脓疱病,发现狼疮和系统性硬皮病。上述疾病并存的一种可能的解释是,炎症理论可能适用于抑郁症,其中的各种元素也适用于自身免疫性疾病。
    Depressive disorders are a growing problem worldwide. They are also characterized by high comorbidity, including from the circle of dermatological diseases. Autoimmune diseases seem to be particularly correlated with depressive comorbidity, raising the question of their possible common pathomechanism. The PubMed database was searched, focusing on results published after 2016. A particular reciprocal correlation of depressive disorders with psoriasis, atopic dermatitis, alopecia areata, impetigo, lupus and systemic scleroderma was found. One possible explanation for the co-occurrence of the above diseases is that the inflammatory theory may be applicable to depression, the various elements of which also apply to autoimmune diseases.
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  • 文章类型: Journal Article
    这篇评论评估了使用基于智能手机的语音数据来预测和监测抑郁症的情况。
    进行了范围审查,检查Medline的14项研究,Scopus,和WebofScience(2010-2023)关于语音数据收集方法和使用语音功能来监测抑郁症。
    语音数据,尤其是基频和音调等韵律特征,显示出预测抑郁症的希望,尽管它们唯一的预测能力需要进一步验证。已显示将语音与多模态传感器数据集成可以显着提高准确性。
    基于智能手机的语音监控提供了一个有前途的,非侵入性,和经济有效的抑郁症管理方法。机器学习与传感器数据的集成可以显着增强心理健康监测,需要进一步的研究和纵向研究进行验证。
    UNASSIGNED: This review evaluates the use of smartphone-based voice data for predicting and monitoring depression.
    UNASSIGNED: A scoping review was conducted, examining 14 studies from Medline, Scopus, and Web of Science (2010-2023) on voice data collection methods and the use of voice features for minitoring depression.
    UNASSIGNED: Voice data, especially prosodic features like fundamental frequency and pitch, show promise for predicting depression, though their sole predictive power requires further validation. Integrating voice with multimodal sensor data has been shown to improve accuracy significantly.
    UNASSIGNED: Smartphone-based voice monitoring offers a promising, noninvasive, and cost-effective approach to depression management. The integration of machine learning with sensor data could significantly enhance mental health monitoring, necessitating further research and longitudinal studies for validation.
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  • 文章类型: Editorial
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    背景:大脑静息状态网络被认为与抑郁症密切相关。然而,脑网络与抑郁障碍之间的因果关系仍存在争议.在这项研究中,我们旨在通过双向孟德尔随机化(MR)设计,研究静息态网络对抑郁障碍的影响.
    方法:更新的与静息态网络相关的汇总水平全基因组关联研究(GWAS)数据来自复杂性状遗传学实验室对欧洲裔GWAS的荟萃分析。抑郁症相关的GWAS数据来自FinnGen研究,涉及具有欧洲血统的参与者。进行了大脑的静息状态功能磁共振成像和多波段扩散成像,以测量七个众所周知的网络中的功能和结构连通性。方差反加权被用作主要估计,而MR-Pleiothypeotropival和异常值(PRESSO),MR-Egger,加权中位数用于检测异质性,灵敏度,和多功能性。
    结果:总计,分析了来自48,847名患者和225,483名对照的20,928个功能和20,573个结构连接数据以及与抑郁相关的GWAS数据。在逆方差加权边缘网络(优势比,[公式:见正文];95%置信区间,[公式:见文本];[公式:见文本]),而未发现抑郁障碍对SCLN的因果影响(OR=1.0025;CI,1.0005-1.0046;P=0.012)。在这项MR研究中,没有发现静息状态网络的功能连通性与抑郁症之间的显着关联。
    结论:这些结果表明,遗传决定的边缘网络的结构连通性对抑郁症具有因果效应,并且可能在其神经病理学中起关键作用。
    BACKGROUND: Cerebral resting-state networks were suggested to be strongly associated with depressive disorders. However, the causal relationship between cerebral networks and depressive disorders remains controversial. In this study, we aimed to investigate the effect of resting-state networks on depressive disorders using a bidirectional Mendelian randomization (MR) design.
    METHODS: Updated summary-level genome-wide association study (GWAS) data correlated with resting-state networks were obtained from a meta-analysis of European-descent GWAS from the Complex Trait Genetics Lab. Depression-related GWAS data were obtained from the FinnGen study involving participants with European ancestry. Resting-state functional magnetic resonance imaging and multiband diffusion imaging of the brain were performed to measure functional and structural connectivity in seven well-known networks. Inverse-variance weighting was used as the primary estimate, whereas the MR-Pleiotropy RESidual Sum and Outliers (PRESSO), MR-Egger, and weighted median were used to detect heterogeneity, sensitivity, and pleiotropy.
    RESULTS: In total, 20,928 functional and 20,573 structural connectivity data as well as depression-related GWAS data from 48,847 patients and 225,483 controls were analyzed. Evidence for a causal effect of the structural limbic network on depressive disorders was found in the inverse variance-weighted limbic network (odds ratio, [Formula: see text]; 95% confidence interval, [Formula: see text]; [Formula: see text]), whereas the causal effect of depressive disorders on SC LN was not found(OR=1.0025; CI,1.0005-1.0046; P=0.012). No significant associations between functional connectivity of the resting-state networks and depressive disorders were found in this MR study.
    CONCLUSIONS: These results suggest that genetically determined structural connectivity of the limbic network has a causal effect on depressive disorders and may play a critical role in its neuropathology.
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  • 文章类型: Journal Article
    背景:阿片类药物的使用与精神疾病发病率之间的关系仍未明确。
    目的:本研究探讨了精神疾病发病率与阿片类药物使用之间的关系。
    方法:这项基于人群的队列研究的数据来自韩国国民健康保险局。该研究包括2016年接受阿片类药物治疗的所有成年患者。对照组包括2016年未接受阿片类药物的个体,并采用1:1分层随机抽样程序进行选择。2016年诊断有精神疾病病史的患者被排除在外。主要终点是精神疾病的诊断,评估时间为2017年1月1日至2021年12月31日。精神疾病包括精神分裂症,情绪障碍,焦虑和其他。
    结果:分析包括3505982名参与者。2016年,这些参与者中有1455829人(41.5%)服用了阿片类药物。具体来说,1187453人(33.9%)接受阿片类药物1-89天,而268376(7.7%)接受阿片类药物治疗≥90天。在多变量Cox回归模型中,接受阿片类药物治疗的患者的精神疾病发生率比没有接受阿片类药物治疗的患者高13%(风险比1.13;95%CI1.13~1.14).此外,1-89天和≥90天的阿片类药物处方中,精神疾病的发生率高13%(危险比1.13,95%CI1.12-1.14)和17%(危险比1.17,95%CI1.16-1.18),分别,与那些没有接受阿片类药物的人相比。
    结论:这项研究表明,精神疾病的增加与阿片类药物的使用有关。这种关联在短期和长期阿片类药物使用中都很重要。
    BACKGROUND: The relationship between opioid use and the incidence of psychiatric disorders remains unidentified.
    OBJECTIVE: This study examined the association between the incidence of psychiatric disorders and opioid use.
    METHODS: Data for this population-based cohort study were obtained from the National Health Insurance Service of South Korea. The study included all adult patients who received opioids in 2016. The control group comprised individuals who did not receive opioids in 2016, and were selected using a 1:1 stratified random sampling procedure. Patients with a history of psychiatric disorders diagnosed in 2016 were excluded. The primary end-point was the diagnosis of psychiatric disorders, evaluated from 1 January 2017 to 31 December 2021. Psychiatric disorders included schizophrenia, mood disorders, anxiety and others.
    RESULTS: The analysis included 3 505 982 participants. Opioids were prescribed to 1 455 829 (41.5%) of these participants in 2016. Specifically, 1 187 453 (33.9%) individuals received opioids for 1-89 days, whereas 268 376 (7.7%) received opioids for ≥90 days. In the multivariable Cox regression model, those who received opioids had a 13% higher incidence of psychiatric disorder than those who did not (hazard ratio 1.13; 95% CI 1.13-1.14). Furthermore, both those prescribed opioids for 1-89 days and for ≥90 days had 13% (hazard ratio 1.13, 95% CI 1.12-1.14) and 17% (hazard ratio 1.17, 95% CI 1.16-1.18) higher incidences of psychiatric disorders, respectively, compared with those who did not receive opioids.
    CONCLUSIONS: This study revealed that increased psychiatric disorders were associated with opioid medication use. The association was significant among both short- and long-term opioid use.
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