Dental Occlusion

牙科闭塞
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    文章类型: English Abstract
    目的:探讨成人和青少年下颌偏位患者的咬合与双侧颞下颌关节(TMJ)间隙的相关性,并研究咬合与下颌位置的相互影响。以期为临床治疗提供参考。
    方法:选择下颌偏曲患者(成人20例,青少年20例)的CBCT资料。Inivo5牙科解剖软件用于重建结构。测量了从犬齿到第一磨牙的双侧上颌的咬合斜度和垂直高度,并计算了两侧相同牙齿之间的垂直高度差。前部,两组分别测量颞下颌关节上间隙和后间隙。采用SPSS17.0软件包对咬合倾斜与双侧髁空间进行Pearson相关性分析。
    结果:在少年组中,偏侧咬合斜度与颞下颌关节上间隙呈负相关(P<0.05)。幼组犬的垂直高度差与偏侧TMJ前间隙呈负相关(P<0.05).在成人组中,相关检查间无明显相关性(P>0.05)。
    结论:下颌偏位患者早期咬合与下颌位置呈中度相关。下颌偏斜的早期治疗对于防止其发展为严重的骨骼错牙合非常重要。额叶倾斜遮挡平面的矫正应给予更多的关注。
    OBJECTIVE: To investigate the correlation between the occlusal canting and the bilateral temporomandibular joint (TMJ) space in adult and juvenile mandibular deviation patients and study the mutual influence between the occlusal canting and mandibular position, in order to provide references for clinical treatment.
    METHODS: CBCT data of mandibular deviation patients(20 adults,20 juveniles)were selected. Inivo5 Dental Anatomage software was used to reconstruct the structures. The occlusal cant and vertical height of the bilateral maxillary from canines to first molars were measured, and the vertical heights difference between the same teeth on both sides was calculated. The anterior, superior and posterior space of temporomandibular joint were measured respectively in both groups. Pearson correlation analysis between the occlusal canting and bilateral condylar space was carried out by using SPSS 17.0 software package.
    RESULTS: In the juvenile group, negative correlations were found between the occlusal cant and the superior TMJ space on the deviated side (P<0.05). Negative correlation was found between the vertical height difference of bilateral canines and the anterior TMJ space on the deviated side in the juvenile group(P<0.05). In the adult group, no significant correlation was observed among those correlated examination (P>0.05).
    CONCLUSIONS: The occlusal canting is moderately correlated with mandibular position in the early stage of mandibular deviation patients. Early treatment of mandibular deviation is of great importance in preventing its progression into severe skeletal malocclusion, and more attention should be paid on the correction of the canted frontal occlusion plane.
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  • 文章类型: Journal Article
    背景:双侧后牙合(BPXB)是与上颌骨发育不全相关的严重错牙合畸形。BPXB可以在侧面之间包括相同或不同数量的齿。
    目的:评估BPXB的咀嚼功能以及咀嚼改变与BPXB咬合特征之间的关系。
    方法:这项观察性研究包括170名参与者:130名BPXB患者(65个八位对称BPXB,即两侧交叉咬合的后牙数量和类型相同,F=33,M=32,中位年龄9.6(8.2-13)[岁。个月];65例患者闭眼不对称BPXB,F=30,M=35,中位年龄9.9(8.3-13.6))和40个对照(F=25,M=15,中位年龄10.2(9.4-11.6))。咀嚼功能是通过检测使用标准化的软糖和硬丸剂用运动分析仪记录的反向咀嚼周期(RCC)来评估的。
    结果:与对照组相比,所有BPXB患者的RCC频率均显着增加(p<.000)。在对称BPXB患者中,左侧或右侧咀嚼过程中RCC的频率没有显着差异。在不对称BPXB患者中,在交叉咬牙的牙齿相对较多的一侧咀嚼时,RCC的频率显着增加(p<.000)。
    结论:所有BPXB患者的咀嚼功能均发生了显著改变,并且受错牙合的对称或不对称咬合特征的影响不同。
    BACKGROUND: Bilateral posterior crossbite (BPXB) is a severe malocclusion associated with maxillary hypoplasia. BPXB may involve the same or a different number of teeth between the sides.
    OBJECTIVE: To evaluate the masticatory function in BPXB and the association between the masticatory alterations and the occlusal features of BPXB.
    METHODS: This observational study included 170 participants: 130 patients with BPXB (65 occlusally symmetric BPXB, i.e. same number and type of posterior teeth in crossbite between the sides, F = 33, M = 32, median age 9.6 (8.2-13) [years.months]; 65 patients occlusally asymmetric BPXB, F = 30, M = 35, median age 9.9 (8.3-13.6)) and 40 controls (F = 25, M = 15, median age 10.2 (9.4-11.6)). The masticatory function was evaluated by the detection of the Reverse Chewing Cycles (RCCs) recorded with a kinesiograph using standardised soft and hard boluses.
    RESULTS: The frequency of RCCs was significantly increased in all BPXB patients compared to controls (p < .000). In symmetric BPXB patients, there were no significant differences in the frequency of RCCs during chewing on the left or the right side. In asymmetric BPXB patients, the frequency of RCCs was significantly increased during chewing on the side with relatively more teeth in crossbite (p < .000).
    CONCLUSIONS: The masticatory function was significantly altered in all BPXB patients and it was differently affected by symmetric or asymmetric occlusal features of the malocclusion.
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  • 文章类型: Journal Article
    本研究旨在使用OXIS分类评估正畸治疗前后邻间接触的变化。OXIS指的是断开(O)的触点类型,点接触(X),直线接触(I),和弯曲接触(S),因此首字母缩写“OXIS”。在三个时间点获得了30名正畸患者的邻间接触数据:T0,治疗开始时;T1,固定矫治器治疗结束时;T2,治疗后一年。对于上颌第二磨牙-第一磨牙接触,T0时最常见的接触是“S”模式(41.6%),在T1时增加到61.6%,在T2时减少到48.3%。对于上颌第一磨牙-第二前磨牙接触,上颌第二前磨牙-第一前磨牙接触,和上颌第一前磨牙-犬齿接触,T0时最常见的接触是“I”模式(58.3%,46.5%和43.3%,分别),增加到88.3%,93.3%和73.3%,分别在T1和下降到80%,88.3%和71.6%,分别在T2。对于上颌尖牙-侧切牙接触和侧切牙-中切牙接触,T0时最常见的接触是“O”模式(45%和33.3%),而T1时(63.3%和80%)和T2时(58.3%和80%)是“X”模式。对下颌后牙和前牙也进行了类似的观察。下颌接触的大部分变化有统计学意义(p<0.05)。从T0到T1,邻间接触发生显着变化。在后段的T1和T2处,较宽的接触是正常的。在T2时,在后段观察到邻间接触的变化,有大量证据,尤其是下颌弓.
    This study aimed to assess the changes in interproximal contacts before and after orthodontic treatment using the OXIS classification. OXIS refers to the types of contacts that is open (O), point contact (X), straight contact (I), and curved contact (S), and thus the acronym \"OXIS\". Interproximal contact data of 30 orthodontic patients were obtained at three time points: T0, at the beginning of treatment; T1, at the end of fixed appliance treatment; and T2, one-year post-treatment. For the maxillary second molar-first molar contact, the most common contact at T0, was the \"S\" pattern (41.6%) which increased to 61.6% at T1 and reduced to 48.3% at T2. For the maxillary first molar-second premolar contact, maxillary second premolar-first premolar contact, and maxillary first premolar-canine contact, the most common contact at T0 was the \"I\" pattern (58.3%, 46.5% and 43.3%, respectively), which increased to 88.3%, 93.3% and 73.3%, respectively at T1 and decreased to 80%, 88.3% and 71.6%, respectively at T2. For the maxillary canine-lateral incisor contact and lateral-central incisor contact, the most common contact at T0 was the \"O\" pattern (45% and 33.3%) while it was the \"X\" pattern at T1 (63.3% and 80%) and T2 (58.3% and 80%). A similar observation was made for the posterior mandibular and anterior teeth. There was statistical significance for most of the changes in the mandibular contacts (p ˂ 0.05). Interproximal contacts change significantly from T0 to T1. Broader contacts were normal at T1 and T2 in the posterior segments. At T2, changes in the interproximal contacts were observed in the posterior segments, and substantial evidence was available, particularly for the mandibular arch.
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  • 文章类型: Journal Article
    这项研究旨在评估咬合负荷对二次牙萌出的影响,并通过实验大鼠模型确定改变咬合负荷对二次牙萌出的影响程度。本样品由48只雄性Wistar大鼠组成。在实验开始时,24只4周龄大鼠(幼年大鼠)和24只26周龄大鼠(成年大鼠)。在每个年龄组中,将大鼠进一步分为两个相等的亚组(每组12只大鼠),在3个月的实验持续时间内接受软食或硬食饮食。主要结果是通过评估下颌第一磨牙与下牙槽管之间的距离,相对于冠状平面中稳定参考的牙齿位置变化。在3个月的研究期间,以三个标准化间隔对所有大鼠进行显微计算机断层扫描。描述性统计数据是按年龄和饮食随时间的变化计算的,结果的演变是按年龄和饮食随时间的变化绘制的。通过广义估计方程进行纵向数据分析,以检查年龄的影响,饮食和时间对主要结果的影响。在所有年龄组(年轻人和成年人)中,无论饮食一致性(软或硬食物)均观察到继发性牙齿萌出。在年轻的老鼠中,喂食软饮食的动物比喂食硬饮食的动物的二次喷发更大。在成年大鼠中,在不同的饮食一致性之间,继发性牙齿萌出的差异最小。咬合负荷会影响已建立咬合接触的牙齿的二次牙齿萌出。当咬合负荷较少时,生长中的大鼠的喷发量较高,提供一定量的二次牙齿萌出发生。这种差异,然而,在成年大鼠中并不明显,至少在给定的3个月时间范围内。
    This study aimed to assess the impact of occlusal loading on secondary tooth eruption and to determine the extent to which altering the occlusal loading influences the magnitude of secondary eruption through an experimental rat model. The present sample consisted of 48 male Wistar rats. At the onset of the experiment, 24 rats were 4 weeks old (young rats) and 24 rats were 26 weeks old (adult). Within each age group, the rats were further divided into two equal subgroups (12 rats each), receiving either a soft- or hard-food diet for the 3-month duration of the experiment. The primary outcome was the tooth position changes relative to stable references in the coronal plane by evaluating the distance between the mandibular first molars and the inferior alveolar canal. Microcomputed tomography scans were taken from all rats at three standardized intervals over the 3-month study period. Descriptive statistics were calculated by age and diet over time, and the evolution of the outcomes were plotted by age and diet over time. Longitudinal data analysis via generalized estimating equations was performed to examine the effect of age, diet and time on the primary outcomes. Secondary tooth eruption was observed in all age groups (young and adult) regardless of diet consistency (soft or hard food). In young rats, the secondary eruption was greater in the animals fed a soft diet than those fed a hard diet. In adult rats, minimal difference in secondary tooth eruption were found between different diet consistencies. Occlusal loading influences secondary tooth eruption in teeth with an established occlusal contact. The quantity of eruption in growing rats is higher when occlusal loading is less, providing a certain amount of secondary tooth eruption occurs. This difference, however, is not evident in adult rats, at least during the given 3-month time frame.
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  • 文章类型: Journal Article
    目的:研究了II类骨骼性II类错牙合的成年人的切缘引导角(IGA)和咬合平面角与颞下颌关节(TMJ)形态之间的相关性。
    方法:对37例患者的CBCT图像进行分析。其中骨性II类II类低角度错牙合19例(研究组),骨性I类平均角度18例(对照组)。采用InvivoDental5软件采集切缘引导角(IGA)数据,咬合平面角度(FH-OP),前咬合平面角度(FH-AOP)和TMJ测量项目。
    结果:IGA的结果,FH-AOP角和FH-OP角显示研究组>对照组(P<0.05)。髁突中外侧直径有统计学差异,关节隆起倾斜度和高度,两组之间的后关节间隙。髁前后径没有发现差异,髁倾角,髁头的宽度和高度,髁突长度,关节盂窝深度和宽度在两组之间。在研究小组中,IGA与FH-AOP呈中等相关性,与FH-OP和髁突中外侧直径弱相关。同时,FH-AOP之间存在相关性,FH-OP,和TMJ指标。
    结论:IGA不仅与FH-AOP和FH-OP有关,而且是髁突中外侧直径。此外,在骨骼II类II类低角度错牙合中,咬合平面角度与TMJ形态之间存在相关性。
    结论:对于骨骼II类II类低角度错牙合的患者,调整IGA和咬合平面角度可以改善前牙的美观,咬合功能,和TMJ形态学。
    OBJECTIVE: The correlations between the incisal guidance angle (IGA) and occlusal plane angles and temporomandibular joint (TMJ) morphology were investigated in adults with skeletal Class II division II malocclusion.
    METHODS: CBCT images of 37 patients were analyzed. It included 19 cases of skeletal Class II division II malocclusion with low angle (study group) and 18 cases of skeletal Class I average angle (control group). The Invivo Dental 5 software was employed to acquire the data of the incisal guidance angle (IGA), occlusal plane angle (FH-OP), anterior occlusal plane angle (FH-AOP) and the TMJ measurement items.
    RESULTS: The results of IGA, FH-AOP angle and FH-OP angle showed the study group > the control group (P < 0.05). There were statistically difference in the condylar mediolateral diameters, articular eminence inclination and height, and posterior joint spaces between two groups. No differences were revealed in the condylar anteroposterior diameters, the condylar inclination angle, condylar head width and height, condylar length, glenoid fossa depth and width between two groups. In the study group, IGA showed a moderate correlation with FH-AOP, a weak correlation with FH-OP and condylar mediolateral diameters. Meanwhile, there was a correlation between FH-AOP, FH-OP, and TMJ indicators.
    CONCLUSIONS: The IGA was not only related to FH-AOP and FH-OP, but also to the condylar mediolateral diameters. In addition, there was a correlation between the occlusal plane angles and TMJ morphology in skeletal Class II division II low angle malocclusion.
    CONCLUSIONS: For patients with skeletal Class II division II low angle malocclusion, adjusting the IGA and the occlusal plane angles could improve the esthetic appearance of the anterior teeth, occlusal function, and TMJ morphology.
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  • 文章类型: Journal Article
    背景和目的:本研究分析并比较了健康受试者和颞下颌关节紊乱病(TMDs)受试者在静水临时口腔夹板(AqualizerUltra)治疗前后使用T-ScanIII的咬合力的分布模式。材料和方法:根据回忆和对Fonseca问卷的回答,将51名受试者分为几组。第一组,非TMD组(n=19),第二组,TMDs组(n=32),有轻度到重度的TMD,正如丰塞卡问卷所确定的那样。非TMD组的平均年龄为25.4岁(SD=4.8,范围20-38),其中15名女性(78.95%)和4名男性(21.05%)。TMDs组的平均年龄为27.4岁(SD=7.0,范围22-53),其中25名女性(78.125%)和7名男性(21.875%)。在使用静水夹板之前和之后,使用T-ScanIII装置进行咬合分析。结果:在使用静水夹板前后,TMD组的右前后力百分比存在显着差异。静水夹板治疗前后每个部门的力分布分析显示,非TMD组没有显着差异。对整个研究人群在静水夹板治疗前后的力分布分析显示,右前和右后区域存在显着差异。使用静水夹板后,前区的咬合力增加了32-56%,后区的咬合力降低了。结论:无论TMD的严重程度如何,都建议将液压夹板疗法作为全口康复治疗的一部分。
    Background and objectives: This study analyzed and compared the distribution patterns of occlusal forces using T-Scan III before and after the hydrostatic temporary oral splint (Aqualizer Ultra) therapy in healthy subjects and subjects with temporomandibular disorders (TMDs). Materials and Methods: Fifty-one subjects were divided into groups based on anamnesis and responses to the Fonseca questionnaire. The first group, non-TMDs group (n = 19), and the second group, TMDs group (n = 32), had mild-to-severe TMDs, as identified by the Fonseca questionnaire. The non-TMDs group had an average age of 25.4 years (SD = 4.8, range 20-38) with 15 females (78.95%) and 4 males (21.05%). The TMDs group had an average age of 27.4 years (SD = 7.0, range 22-53) with 25 females (78.125%) and 7 males (21.875%). T-Scan III device was used for occlusal analysis before and after hydrostatic splint usage. Results: Significant differences were observed in the TMDs group for anterior and posterior right percentages of forces before and after hydrostatic splint usage. The analysis of force distribution per sector before and after hydrostatic splint therapy showed no significant differences in the non-TMDs group. Analysis of force distributions in the entire study population before and after hydrostatic splint therapy showed significant differences in the anterior and posterior right regions. Occlusal force increased by 32-56% in the front region and decreased in the posterior area after hydrostatic splint usage. Conclusions: Hydrostatic splint therapy is recommended as a part of full-mouth rehabilitation treatment for all patients regardless of the severity of TMDs.
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  • 文章类型: Journal Article
    The clinical demand for occlusal reconstruction increases rapidly with increasing number of patients who have lost their normal occlusion because of tooth wear and dentition defects. Occlusal reconstruction is a special type of restoration defined as a comprehensive restoration of the function of the stomatognathic system by reestablishing a uniform and stable occlusal relationship between the upper and lower dentitions. Occlusal function analysis is an important part of occlusal reconstruction to achieve accurate restoration design and adjustment. Digital occlusal function analysis was conducted to monitor the movement of the mandible and obtain related data for the parameter design of occlusal reconstruction. Preoperative design, intraoperative adjustment, and postoperative verification were achieved, thereby improving the efficiency and accuracy of occlusal reconstruction.
    随着牙齿磨损、牙列缺损等导致正中 关系丧失的患者增多,咬合重建的临床需求也在增加。咬合重建是一种通过重新建立均匀稳定的上下牙列咬合关系以恢复口颌系统功能的一种特殊修复方式。如何进行咬合功能分析以实现精准的修复设计与调整是咬合重建中极其重要的一环。本文报告了1例利用数字化咬合功能分析获取咬合及下颌运动相关参数用于咬合重建修复体设计的病例,达到术前设计、术中调整、术后验证的目的,使得咬合重建进行得更加高效准确。.
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  • 文章类型: Journal Article
    再吸收牙槽脊,特别是在下颚,有一个小的义齿支撑区,这可能会导致咀嚼负荷的应力分布超过压力-疼痛阈值(PPT),并引起粘膜疼痛或潜在地加重脊吸收。因此,在双边平衡(BBO)中选择理想的咬合方案,语言化(LO),单平面(MO)对于这样的条件变得至关重要。实验是使用有限元方法对下颌中再吸收的牙槽脊进行建模的,上面放置了三个假牙,根据BBO的齿排列,每个都有不同的加载点,LO,和MO。轴向载荷为100N,BBO和LO的最终斜载分别为119N和106N,分别。冯·米塞斯对BBO的强调,LO,在九个义齿支撑区域观察到MO,结果表明,对于BBO,轴向载荷不会产生超过PPT值(0.64925MPa)的应力,LO,和MO在区域H上的最高值,0.43229MPa,0.39715MPa,和0.31576兆帕,分别。然而,倾斜载荷方向表明BBO的面积(面积E0.80778MPa和面积H0.76256MPa)超过PPT的面积比LO(面积E0.64394MPa)多。语言咬合方案是理想的患者再吸收牙槽的条件,特别是当义齿在保持舒适性的同时仍提供良好的咀嚼性能和令人满意的美学效果时限制干扰。
    Resorbed alveolar ridges, particularly in the lower jaw, have a small denture supporting area, which may cause the stress distribution of mastication load to exceed the pressure-pain threshold (PPT) and induce pain in the mucosa or potentially worsen the ridge resorption. Thus, choosing the ideal occlusal scheme among bilateral balanced (BBO), lingualized (LO), and monoplane (MO) for such conditions becomes crucial. The experiment was conducted using the finite element method on a modeling of a resorbed alveolar ridge in the lower jaw with three dentures placed on top, each of which was given different loading points according to the tooth arrangement of BBO, LO, and MO. The axial load was 100 N, and the resultant oblique loads on BBO and LO were 119 N and 106 N, respectively. The von Mises stresses for BBO, LO, and MO were observed in nine denture-supporting areas, and the results showed that the axial load did not produce stresses that exceeded the PPT value (0.64925 MPa) for BBO, LO, and MO with the highest value on area H, 0.43229 MPa, 0.39715 MPa, and 0.31576 MPa, respectively. However, the oblique load direction showed that the BBO had more areas (area E 0.80778 MPa and area H 0.76256 MPa) that exceeded the PPT than LO (area E 0.64394 MPa). The lingualized occlusal scheme is ideal for patients with resorbed alveolar ridge conditions, especially in terms of limiting interferences when the denture is functioning while maintaining comfort but still providing good masticatory performance and satisfactory esthetics.
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  • 文章类型: Journal Article
    目的:本研究旨在调查偏头痛患者(MG)组和对照组(CG)之间功能性咬合变量的可能差异。
    方法:每组包括50名个体。进行仪器功能分析和数字咬合分析。检查的变量是从参考位置到最大切口的con突位移;关节隆起的陡度与对侧犬齿引导之间的角度差;关节隆起的陡度与同侧中央切牙引导和咬合面倾斜度之间的角度差。还研究了自我报告的磨削和咬合指数。
    结果:两种临床评估的后髁突移位程度差异有统计学意义[MG:0.49mm(SD0.67mm),CG:0.29mm(SD0.27mm),p=0.012]和数字机械[MG:1.53mm(SD0.95mm),CG:0.9mm(SD0.66mm),p=0.001],关节隆起的陡度和对侧犬导向之间的角度差[MG:13.11°(SD8.33°),CG:9.47°(SD7.08°),p=0.021,MG:12.94°(SD8.71°),CG:9.44°(SD8.70°),p=0.017],和咬合面倾角[MG:11.16°(SD4.66°),CG:9.09°(SD4.37°),p=0.024]。自我报告的磨削(MG:39/50,CG:12/50,p<0.001)和咬合指数[MG:1.92(SD0.46),CG:0.21(SD0.66),p<0.001]在偏头痛患者中也明显更高。
    结论:关节和咬合结构可能在偏头痛中起作用,因此应采用跨学科的方法加以考虑。
    OBJECTIVE: This study aimed to investigate possible differences of functional occlusal variables between a group of migraine patients (MG) and a control group (CG).
    METHODS: Each group included 50 individuals. Instrumental functional analysis and digital occlusal analysis were performed. Variables examined were condylar displacement from a reference position to maximum intercuspation; angular difference between the steepness of the articular eminence and the contra-lateral canine guidance; and angular difference between the steepness of the articular eminence and the ipsilateral central incisor guidance and occlusal plane inclination. Self-reported grinding and occlusal index were also investigated.
    RESULTS: There were statistically significant differences in the extent of retral condylar displacement assessed both clinically [MG: 0.49 mm (SD 0.67 mm), CG: 0.29 mm (SD 0.27 mm), p = 0.012] and digital-mechanically [MG: 1.53 mm (SD 0.95 mm), CG: 0.9 mm (SD 0.66 mm), p = 0.001], the angular difference between the steepness of the articular eminence and the contra-lateral canine guidance [MG: 13.11° (SD 8.33°), CG: 9.47° (SD 7.08°), p = 0.021 and MG: 12.94° (SD 8.71°), CG: 9.44° (SD 8.70°), p = 0.017], and the occlusal plane inclination [MG: 11.16° (SD 4.66°), CG: 9.09° (SD 4.37°), p = 0.024]. Self-reported grinding (MG: 39/50, CG: 12/50, p < 0.001) and occlusal index [MG: 1.92 (SD 0.46), CG: 0.21 (SD 0.66), p < 0.001] were also significantly higher in migraineurs.
    CONCLUSIONS: Articular and occlusal structures could play a role in migraine and thus should be considered in an interdisciplinary approach.
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  • 文章类型: Journal Article
    目的:牙周炎是一种常见的口腔疾病,因咬合创伤而加重。纤维蛋白是一种参与血液凝固的蛋白质,与几种人类疾病有关。牙周组织中纤维蛋白的沉积可以诱发牙周炎,而机械力可以调节纤维蛋白的降解。我们的研究调查了咬合创伤如何通过调节纤溶酶原/纤溶酶系统和纤维蛋白沉积来加重牙周炎。
    方法:这项研究包括84只C57BL/6小鼠,其中有或没有咬合创伤引起牙周炎。显微计算机断层扫描用于评估骨吸收。纤维蛋白,纤维蛋白原,纤溶酶原,纤溶酶,组织纤溶酶原激活剂(t-PA),和尿激酶纤溶酶原激活物(u-PA)水平测量使用Frazer-Lendrum染色,定量逆转录聚合酶链反应,酶联免疫吸附测定,西方印迹,免疫荧光染色,和免疫组织化学染色。
    结果:咬合创伤加重炎症和骨吸收。牙周炎组显示显著的纤维蛋白沉积。咬合创伤增加了纤维蛋白沉积和中性粒细胞聚集。牙周炎伴咬合创伤组纤维蛋白原降低,t-PA,和u-PA表达和纤溶酶和纤维蛋白降解产物水平,以及增加的纤溶酶原水平。
    结论:咬合创伤通过抑制纤溶酶原/纤溶酶系统促进过度的纤维蛋白沉积,从而加剧牙周炎。
    OBJECTIVE: Periodontitis is a common oral disease that is aggravated by occlusal trauma. Fibrin is a protein that participates in blood clotting and is involved in several human diseases. The deposition of fibrin in periodontal tissues can induce periodontitis, while mechanical forces may regulate the degradation of fibrin. Our study investigated how occlusal trauma aggravating periodontitis through regulating the plasminogen/plasmin system and fibrin deposition.
    METHODS: This study included 84 C57BL/6 mice in which periodontitis was induced with or without occlusal trauma. Micro-computed tomography was used to assess bone resorption. Fibrin, fibrinogen, plasminogen, plasmin, tissue plasminogen activator (t-PA), and urokinase plasminogen activator (u-PA) levels were measured using Frazer-Lendrum staining, quantitative reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, western blotting, immunofluorescence staining, and immunohistochemistry staining.
    RESULTS: Occlusal trauma aggravated inflammation and bone resorption. The periodontitis group showed significant fibrin deposition. Occlusal trauma increased fibrin deposition and neutrophil aggregation. The periodontitis with occlusal trauma group had decreased fibrinogen, t-PA, and u-PA expression and plasmin and fibrin degradation product levels, as well as increased plasminogen levels.
    CONCLUSIONS: Occlusal trauma promotes excessive fibrin deposition by suppressing the plasminogen/plasmin system, thus exacerbating periodontitis.
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