未经批准：广泛耐药结核病（XDR-TB）被认为是对全球健康的主要威胁。本研究旨在分析广泛耐药结核病患者的治疗结果，并确定与不良治疗结果显著相关的因素。
UNASSIGNED：我们在巴基斯坦国家结核病控制计划的10个计划管理单位进行了一项回顾性观察研究。电子名义记录报告系统记录用于收集2012年3月至2018年8月在研究中心登记的所有合格的XDR-TB患者的数据。根据标准标准分析治疗结果。采用多元二元logistic回归分析与不良治疗结果相关的因素。
未经证实：在总共184名患者中，59（32.1％）成功完成了治疗。由此,83例(45.1%)死亡,24人（13%）治疗失败，11例(6%)失访.7例（3.8%）患者未评估治疗结果。与不利的治疗结果显著相关的因素包括;常规治疗与bedaquiline,不利的中期治疗结果和不良药物事件的发生（负关联）。
未经评估：研究队列中的治疗成功率次优（即，<75%）。低成功率和高死亡率令人担忧，并需要项目经理和临床医生的立即关注。
UNASSIGNED: Extensively drug resistant tuberculosis (XDR-TB) is considered as a major threat to global health. This study aimed to analyse the treatment outcomes and identify the factors significantly associated with unfavourable treatment outcomes among XDR-TB patients.
UNASSIGNED: We conducted a retrospective observational study at 10 Programmatic Management Units of the National Tuberculosis Control Program of Pakistan. The Electronic Nominal Recording Reporting System records were used to collect data of all eligible XDR-TB patients registered at the study sites between March 2012 and August 2018. Treatment outcomes were analysed as per the standard criteria. Factors associated with unfavourable treatment outcomes were analysed by using multivariate binary logistic regression analysis.
UNASSIGNED: Out of the total 184 patients, 59 (32.1%) completed their treatment successfully. Whereby, 83 patients (45.1%) died, 24 (13%) had treatment failure, and 11 (6%) were lost to follow-up. Treatment outcomes were not evaluated in 7 (3.8%) patients. Factors significantly associated with unfavourable treatment outcomes included; conventional therapy with bedaquiline, unfavourable interim treatment outcomes and occurrence of adverse drug events (negative association).
UNASSIGNED: Treatment success rate in the study cohort was sub-optimal (i.e., <75%). The poor success rate and high mortality are concerning, and requires immediate attention of the program managers and clinicians.
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