关键词: AFB, acid-fast bacilli BAL, bronchoalveolar lavage Bedaquiline CNS, central nervous system CSF, cerebrospinal fluid CT, computerized tomography Central nervous system (CNS) TB DOT, directly observed therapy DST, drug susceptibility testing Extensively drug-resistant tuberculosis (XDR-TB) FDA, Food and Drug Administration IV, intravenous LUL, left upper lobe MDR-TB, multidrug-resistant tuberculosis MRI, magnetic resonance imaging Multi-drug resistant tuberculosis (MDR-TB) TB, tuberculosis Tuberculoma Tuberculosis (TB) WHO, World Health Organization XDR-TB, extensively drug-resistant tuberculosis

来  源:   DOI:10.1016/j.jctube.2017.12.004   PDF(Pubmed)

Abstract:
Tuberculosis (TB) is one of the leading causes of death worldwide, particularly in low- and middle-income countries. The global rates and numbers of drug resistant TB are rising. With increasing globalization, the spread of drug-resistant strains of TB has become a mounting global public health concern. We present a case of a young man previously treated for multi-drug resistant (MDR) TB in India who presented with neurological symptoms and central nervous system TB in the United States. His case highlights unique diagnostic and treatment challenges that are likely to become more commonplace with the increase of patients infected with drug-resistant TB and complicated extrapulmonary disease.
摘要:
结核病(TB)是世界范围内的主要死亡原因之一,特别是在低收入和中等收入国家。全球耐药结核病的发病率和数量正在上升。随着全球化的加剧,结核病耐药菌株的传播已成为全球公共卫生问题。我们介绍了一例先前在印度接受过耐多药(MDR)TB治疗的年轻人,他在美国出现神经系统症状和中枢神经系统TB。他的案例突出了独特的诊断和治疗挑战,随着感染耐药结核病和复杂肺外疾病的患者的增加,这些挑战可能变得更加普遍。
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