■2019年首次冠状病毒病(COVID-19)感染后,呼吸道症状可能会持续数周。目的和目标是评估临床症状,肺功能,和放射学变化,并评估COVID-19后患者的心血管并发症。
■这项观察性研究是在肺科与心内科合作进行的,SCBMCH,Cuttack,从2021年3月至2022年8月,在接受COVID-19感染治疗后4周至2年出现呼吸道症状的75例患者。COVID后患有呼吸系统疾病的患者被排除在研究之外。
■在75名患者中,最常见的年龄组为18~30岁,男女比例为2.5∶1.根据O2要求,患者分为轻度有症状组和中重度肺炎组。最常见的呼吸道症状是呼吸困难,然后咳嗽咳痰。在17%的病例中发现了双侧pi。在38.6%和32%的患者中,C-反应蛋白(CRP)和D-二聚体升高,分别。42.6%的胸部X线异常,最常见的异常是网状增厚。在肺活量测定中,在49.3%和13.3%的病例中,限制性模式和混合模式是主要类型,分别,在中度-重度组中显著。仅19例患者(轻度组13和中度-重度组6)进行了肺对一氧化碳(DLCO)的扩散能力。12例(63.2%)患者存在异常DLCO。P值对于RV(0.0482)和RV/TLC(0.0394)是显著的。55.7%的胸部高分辨率计算机断层扫描(HRCT)异常,最常见的异常为小叶间隔增厚。所有患者均保留左心室射血分数,2.6%的参与者出现右心房和右心室扩大,4.0%的参与者出现肺动脉高压。
所有从急性COVID-19中恢复后出现呼吸道症状的COVID-19后患者可由家庭护理医师转诊至专门的COVID后中心进行进一步评估,管理,和早期康复,以降低康复患者的发病率。持续增加的血液参数,如TLC,N/L比,苏格兰皇家银行,CRP,在COVID-19后康复的患者中观察到D-二聚体。CT表现对呼吸道症状的长期影响,肺功能,和生活质量是未知的。COVID-19后患者的心血管异常很少见。
UNASSIGNED: Respiratory symptoms may persist for several weeks following the initial coronavirus disease 2019 (COVID-19) infection. The aims and objectives were to assess the clinical symptoms, pulmonary functions, and radiological changes and to assess the cardio-vascular complications in post-COVID-19 patients.
UNASSIGNED: This observational study was conducted in the Department of Pulmonary Medicine in collaboration with the Department of Cardiology, SCBMCH, Cuttack, from March 2021 to August 2022 on 75 post-COVID-19 patients with respiratory symptoms from 4 weeks to 2 years after treatment for COVID-19 infection. Post-COVID patients having previous respiratory diseases were excluded from the study.
UNASSIGNED: Among 75 patients, the most common age group was 18-30 years with a male-to-female ratio of 2.5:1. Based on O2 requirement, patients were divided into the mild symptomatic group and moderate to severe pneumonia group. The most common respiratory symptom was dyspnea, followed by cough with expectoration. Bilateral crepitations were found in 17% of cases. C-reactive protein (CRP) and D-dimer were increased in 38.6% and 32% of patients, respectively. 42.6% had abnormal chest X-ray, and the most common abnormal finding was reticular thickening. In spirometry, the restrictive pattern and mixed pattern were the predominant types documented in 49.3% and 13.3% of cases, respectively, which were significant in the moderate-severe group. Diffusion capacity of the lungs for carbon monoxide (
DLCO) was performed in only 19 patients (mild group 13 and moderate-severe group 6). Twelve (63.2%) patients had abnormal
DLCO. P- values were significant for RV (0.0482) and RV/TLC (0.0394). High-resolution computed tomography (HRCT) of the thorax was abnormal in 55.7% with the most common abnormalities as inter- and intra-lobular septal thickening. The left ventricular ejection fraction was preserved in all patients, with right atrium and right ventricle enlargement in 2.6% and pulmonary hypertension in 4.0% of participants.
UNASSIGNED: All post-COVID-19 patients having respiratory symptoms after recovery from acute COVID-19 may be referred by family care physicians to a dedicated post-COVID center for further evaluation, management, and early rehabilitation to decrease the morbidity in recovered patients. Persistent increased blood parameters like TLC, N/L ratio, RBS, CRP, and D-dimer seen in recovered post-COVID-19 patients. The long-term impact of CT findings on respiratory symptoms, pulmonary functions, and quality of life is unknown. Cardiovascular abnormalities in post-COVID-19 patients are infrequent.