UNASSIGNED: To evaluate characteristics, indications, complications and outcome of obstetric patients admitted to ICU of tertiary care hospital in KPK, Pakistan.
UNASSIGNED: This descriptive study was conducted in department of OBGYN of Lady Reading Hospital, Peshawar from January 2021 till December 2021. A total of 62 patients were enrolled into the study using nonprobability consecutive sampling technique. Their data were collected on a proforma. All patients were followed till their death or discharge home from hospital.
UNASSIGNED: The mean duration of ICU stay of patients, was 6.85 ± 4.82 days. Out of 62 patients 17 (27.41%) expired in ICU, while 45 (72.58%) patients survived and were discharged. Pre-eclampsia and Eclampsia was the commonest primary diagnosis, accounting for 28 cases (45.2%) with a case fatality rate of 25%, followed by 13 cases (21%) of primary postpartum hemorrhage (PPH) as the second commonest reason for ICU admission and a case fatality rate of 38%. The underlying primary diagnosis had no statistically significant association with outcome of the patient. Acute Renal failure had statistically significant association with outcome of the patient with adjusted OR 4.79, CI:1.17-19.66, p-0.02. Similar positive association with mortality existed for patients having DIC (aOR:6.59; CI:1.34-32.34, p-0.02).
UNASSIGNED: Pre-eclampsia/Eclampsia is the commonest reason for intensive care admission, however PPH has the highest case fatality rate. The outcome of critically ill obstetric patients is dependent on complications and not primary underlying diagnosis.

UNASSIGNED: Coagulopathies are frequently observed in alveolar rhabdomyosarcoma (ARMS), with disseminated intravascular coagulation (DIC) being the most common presentation. However, hyperfibrinolysis represents a distinct but often overlapping and potentially life-threatening subset of coagulation disorders that requires specific diagnostic and management approaches.
UNASSIGNED: How can clinicians identify hyperfibrinolysis and what are the implications for management?
UNASSIGNED: This case report describes a 25-year-old man with metastatic ARMS arising from the prostate who developed persistent gross hematuria one week after initiating chemotherapy. A comprehensive coagulation workup was performed, including assessment of platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, and fibrin degradation products. Management included repletion of fibrinogen and the use of anti-fibrinolytic agents.
UNASSIGNED: Recognizing hyperfibrinolysis in ARMS patients is crucial for appropriate management. Clinicians should maintain a high index of suspicion for hyperfibrinolysis in ARMS patients presenting with severe coagulation abnormalities, particularly those with prostatic involvement or undergoing chemotherapy. In cases of primary hyperfibrinolysis, antifibrinolytic agents may be considered, whereas they are generally contraindicated in DIC.

Three-dimensional braided composites (3D-BCs) have better specific strength and stiffness than two-dimensional planar composites (2D-PCs), so they are widely used in modern industrial fields. In this paper, two kinds of 3D four-directional braided composites (3D4d-BCs) with different braided angles (15°, denoted as H15, and 30°, denoted as H30) were subjected to hydrothermal aging treatments, low-velocity impact (LVI) tests, and compression after impact (CAI) tests under different conditions. This study systematically studied the hygroscopic behavior and the effect of hygrothermal aging on the mechanical properties of 3D4d-BC. The results show that higher temperatures and smaller weaving angles can significantly improve the moisture absorption equilibrium content. When the moisture absorption content is balanced, the energy absorption effect of 3D4d-BC is better, but the integrity and residual compression rate will be reduced. Due to the intervention of oxygen molecules, the interface properties between the matrix and the composite material will be reduced, so the compressive strength will be further reduced. In the LVI test, the peak impact load of H15 is low. In CAI tests, the failure of H15 mainly occurs on the side, and the failure form is buckling failure. The main failure direction of H30 is 45° shear failure.

Wire crimping, a process commonly used in the automotive industry, is a solderless method for establishing electrical and mechanical connections between wire strands and terminals. The complexity of predicting the final shape of a crimped terminal and the imperative to minimize production costs indicate the use of advanced numerical methods. Such an approach requires a reliable phenomenological elasto-plastic constitutive model in which material behavior during the forming process is described. Copper alloy sheets, known for their ductility and strength, are commonly selected as terminal materials. Generally, sheet metals exhibit significant anisotropy in mechanical properties, and this phenomenon has not been sufficiently investigated experimentally for copper alloy sheets. Furthermore, the wire crimping process is conducted at higher velocities; therefore, the influence of the strain rate on the terminal material behavior has to be known. In this paper, the influence of the strain rate on the anisotropic elasto-plastic behavior of the copper alloy sheet CuFe2P is experimentally investigated. Tensile tests with strain rates of 0.0002 s-1, 0.2 s-1, 1 s-1, and 5.65 s-1 were conducted on sheet specimens with orientations of 0°, 45°, and 90° to the rolling direction. The influence of the strain rate on the orientation dependences of the stress-strain curve, elastic modulus, tensile strength, elongation, and Lankford coefficient was determined. Furthermore, the breaking angle at fracture and the inelastic heat fraction were determined for each considered specimen orientation. The considered experimental data were obtained by capturing the loading process using infrared thermography and digital image correlation techniques.

This paper shows the three-point bending strength analysis of a composite material consisting of polyamide doped with chopped carbon fiber and reinforced with continuous carbon fiber produced by means of the material extrusion (MEX) additive manufacturing technique. For a comparison, two types of specimens were produced: unreinforced and continuous fiber-reinforced (CFR) with the use of carbon fiber. The specimens were fabricated in two orientations that assure the highest strength properties. Strength analysis was supplemented by additional digital image correlation (DIC) analysis that allowed for the identification of regions with maximum strain within the specimens. The utilization of an optical microscope enabled a fractographic examination of the fracture surfaces of the specimens. The results of this study demonstrated a beneficial effect of continuous carbon fiber reinforcement on both the stiffness and strength of the material, with an increase in flexural strength from 77.34 MPa for the unreinforced composite to 147.03 MPa for the composite reinforced with continuous carbon fiber.

The strain gauge method and the digital image correlation (DIC) method are commonly employed for measuring strain in tested objects, including material specimens and structural elements. The optical method enables the assessment of 3D strain fields across the entire area of interest, achieved through cameras and advanced software. The study investigates both quasi-static strength tests and more advanced research of structures. It explores full-scale construction testing, featuring highly stressed components of new wagon designs. The paper reviews the benefits and challenges of using the DIC method to measure large-scale elements. Conducting full-scale object testing is characterized by significant complexity, often involving interactions between elements, complex loading conditions, and the influence of friction. Numerous factors affect the measurements. Therefore, to compare both methods, an initially standard shear by tensile test of CFRP composite was analyzed. The analysis of strain maps provides valuable visualization of deformation patterns occurring during construction loading. The strain gauge method was crucial for verifying the quality of the DIC measurements. The results obtained provide a detailed understanding of how the components behave, highlighting the versatility of digital image correlation technology. For strain values of 0.3% and above, a good match was obtained between optical and strain gauge measurements. Below this value, the results have less accuracy. The results obtained provide a detailed understanding of how the components behave, highlighting the versatility of digital image correlation technology. The error comparison and discussion between different measurement scenarios were conducted. The paper presents a developed methodology for measuring strain and displacement state in complex and crucial structural elements. The method can be applied to measurements of heavily loaded components used in the transportation industry; for example, in railways.

This research investigates the application of plastic fiber reinforcement in pre-tensioned reinforced concrete railway sleepers, conducting an in-depth examination in both experimental and computational aspects. Utilizing 3-point bending tests and the GOM ARAMIS system for Digital Image Correlation, this study meticulously evaluates the structural responses and crack development in conventional and plastic fiber-reinforced sleepers under varying bending moments. Complementing these tests, the investigation employs ABAQUS\' advanced finite element modeling to enhance the analysis, ensuring precise calibration and validation of the numerical models. This dual approach comprehensively explains the mechanical behavior differences and stresses within the examined structures. The incorporation of plastic fibers not only demonstrates a significant improvement in mechanical strength and crack resistance but paves the way for advancements in railway sleeper technology. By shedding light on the enhanced durability and performance of reinforced concrete structures, this study makes a significant contribution to civil engineering materials science, highlighting the potential for innovative material applications in the construction industry.

In human medicine, hemostatic disorders such as thrombocytopenia, hyperfibrinolysis, and disseminated intravascular coagulopathy (DIC) have been associated with many cancers. Acute hemorrhage secondary to hyperfibrinolysis has been predominantly reported with prostatic adenocarcinoma in human patients. To the author\'s knowledge, severe bleeding due to paraneoplastic hyperfibrinolysis has not yet been reported in veterinary medicine. The case involves an 8-year-old neutered male Border Collie who was evaluated for progressive and recurrent epistaxis, having a history of 1 year of treatment for metastatic nasal adenocarcinoma. A progressive and severe coagulopathy thought to be related to the known cancer was diagnosed. Advanced coagulation testing was consistent with a chronic DIC and secondary hyperfibrinolysis. Throughout 1 week of hospitalization, the dog was treated with multiple blood products, vitamin K1, and anti-fibrinolytic medications. While the dog was initially discharged home, the dog re-presented the following day and was humanely euthanized due to a perceived poor quality of life. Post-mortem analysis revealed a histopathologic diagnosis of disseminated adenocarcinoma. In dogs with disseminated nasal adenocarcinoma that are experiencing severe bleeding, paraneoplastic secondary hyperfibrinolysis should be considered as a differential. Knowing this association could help guide treatment recommendations for optimal patient management.

The personalisation of finite element models is an important problem in the biomechanical fields where subject-specific analyses are fundamental, particularly in studying soft tissue mechanics. The personalisation includes the choice of the constitutive law of the model\'s material, as well as the choice of the material parameters. In vivo identification of the material properties of soft tissues is challenging considering the complex behaviour of soft tissues that are, among other things, non-linear hyperelastic and heterogeneous. Hybrid experimental-numerical methods combining in vivo indentations and inverse finite element analyses are common to identify these material parameters. Yet, the uniqueness and the uncertainty of the multi-material hyperelastic model have not been evaluated. This study presents a sensitivity analysis performed on synthetic indentation data to investigate the identification uncertainties of the material parameters in a bi-material thigh phantom. Synthetic numerical data, used to replace experimental measurements, considered several measurement modalities: indenter force and displacement, stereo-camera 3D digital image correlation of the indented surface, and ultrasound B-mode images. A finite element model of the indentation was designed with either Ogden-Moerman or Mooney-Rivlin constitutive laws for both materials. The parameters\' identifiability (i.e. the possibility of converging to a unique parameter set within an acceptable margin of error) was assessed with various cost functions formulated using the different synthetic data sets. The results underline the need for multiple experimental modalities to reduce the uncertainty of the identified parameters. Additionally, the experimental error can impede the identification of a unique parameter set, and the cost function depends on the constitutive law. This study highlights the need for sensitivity analyses before the design of the experimental protocol. Such studies can also be used to define the acceptable range of errors in the experimental measurement. Eventually, the impact of the evaluated uncertainty of the identified parameters should be further investigated according to the purpose of the finite element modelling.

The objective of this study is to determine the fibrin monomer reference intervals in healthy children. This cross-sectional study was conducted in the Hematology Department at Vietnam National Children\'s Hospital (April 2023 to March 2024). Children without prior history of clotting disorders or anticoagulants use hospitalized in preparation for orthopedic surgery or inguinal hernia surgery were enrolled in the study. The fibrin monomer test method was the quantitative fibrin monomer test on the STA-R system (Diagnostica Stago™, France). Eighty-six children (58 males and 28 females) were enrolled in the study. The median (interquartile range, 2.5th-97.5th) fibrin monomer value of the study subjects was 2.56 (0.11-5.93) µg/mL, with no statistically significant difference in fibrin monomer values among the age groups of 1 month to 3 years, 3 years to 13 years, and 13 years to 18 years. This is the first study conducted in Vietnam to determine reference values of fibrin monomer in children. This information can help in the diagnosis and treatment of early hypercoagulation stage and disseminated intravascular coagulation in children.