PDF(Pubmed)
Abstract：
The objective of this study is to determine the fibrin monomer reference intervals in healthy children. This cross-sectional study was conducted in the Hematology Department at Vietnam National Children\'s Hospital (April 2023 to March 2024). Children without prior history of clotting disorders or anticoagulants use hospitalized in preparation for orthopedic surgery or inguinal hernia surgery were enrolled in the study. The fibrin monomer test method was the quantitative fibrin monomer test on the STA-R system (Diagnostica Stago™, France). Eighty-six children (58 males and 28 females) were enrolled in the study. The median (interquartile range, 2.5th-97.5th) fibrin monomer value of the study subjects was 2.56 (0.11-5.93) µg/mL, with no statistically significant difference in fibrin monomer values among the age groups of 1 month to 3 years, 3 years to 13 years, and 13 years to 18 years. This is the first study conducted in Vietnam to determine reference values of fibrin monomer in children. This information can help in the diagnosis and treatment of early hypercoagulation stage and disseminated intravascular coagulation in children.
摘要：
这项研究的目的是确定健康儿童的纤维蛋白单体参考间隔。这项横断面研究在越南国家儿童医院血液科（2023年4月至2024年3月）进行。这项研究纳入了没有凝血障碍或抗凝剂使用史的儿童，这些儿童在骨科手术或腹股沟疝手术的准备中住院。纤维蛋白单体测试方法是STA-R系统上的定量纤维蛋白单体测试(DiagnosticaStago™，法国)。86名儿童（58名男性和28名女性）被纳入研究。中位数(四分位数间距，2.5-97.5）研究对象的纤维蛋白单体值为2.56（0.11-5.93）µg/mL，1个月至3岁年龄组的纤维蛋白单体值无统计学差异，3年到13年,13年到18年。这是越南进行的第一项确定儿童纤维蛋白单体参考值的研究。这些信息可以帮助儿童早期高凝阶段和弥散性血管内凝血的诊断和治疗。
