背景:囊性肾细胞癌(CRCC)和囊性集合管癌(CCDC)具有相似的致癌基因和一些影像学表现。这项研究的目的是描述CRCC和CCDC的临床和CT影像学特征。
方法:对33例经病理证实的CRCC患者和13例CCDC患者进行回顾性研究。评估肿瘤特征。
结果:关于CT成像,33例(100%)CRCC患者和13例(100%)CCDC患者,肿瘤钙化(8vs.9,P<0.0001),有一个清晰的边界(胶囊标志,30vs.2,P<0.0001),渗透外观(1与13,P<0.0001),外因外观(29vs.3,P<0.0001),侵犯肾盂或输尿管(1vs.10,P<0.0001),出血(1vs.10,P<0.0001),腹膜后淋巴结或远处转移(2vs.10,P<0.0001),增厚增强内隔(31vs.2,P<0.0001),和壁软组织结节(21vs.1,P<0.0001)。在MR成像上,CRCC患者13例(39%),CCDC患者4例(31%),所有CRCC在T1加权图像上出现低信号,在T2加权图像上出现高强度,然而,所有CCDC在T1加权图像上出现低信号,在T2加权图像上出现低信号(P<0.0001).33例CRCC患者,他们都存活了10年到10年的随访,然而,13名CCDC患者,其中11名患者能够得到随访,9名患者在初次诊断后5年内过期,其他人目前仍然活着。
结论:CRCC和CCDC的区别特征包括钙化,胶囊标志,渗透外观,转移,内部败血症,壁画结节和CT或MR图像上的信号。这些成像特征可能有助于区分两种肾肿瘤类型。
BACKGROUND: Cystic renal cell carcinoma (CRCC) and cystic collecting duct carcinoma (CCDC) share similar oncogeni and some imaging findings. The aim of this study was to characterize the clinical and CT imagings features of CRCC and CCDC.
METHODS: Thirty-three patients with CRCC and thirteen patients with CCDC with pathologically proven were retrospectively studied. Tumor characteristics were assessed.
RESULTS: On CT imaging, 33 patients(100 %) with CRCC and 13 patients(100 %) with CCDC, tumors calcifications (8 vs. 9, P < 0.0001), had a clear boundary (capsule sign, 30 vs. 2, P < 0.0001), infiltrative appearance (1 vs. 13, P < 0.0001), exogenous appearance (29 vs. 3, P < 0.0001), invaded the renal pelvis or ureter (1 vs. 10, P < 0.0001), hemorrhage (1 vs. 10, P < 0.0001), had retroperitoneal lymph node or distant metastasis (2 vs. 10, P < 0.0001), thickened enhancing internal septations (31 vs. 2, P < 0.0001), and mural soft-tissue nodules (21 vs. 1, P < 0.0001). On MR imaging,13 patients(39 %) with CRCC and 4 patients(31 %) with CCDC, all CRCCs appeared hypointense on T1-weighted images and hyperintense on T2-weighted images, however, all CCDCs appeared hypointense on T1-weighted images and hypointense on T2-weighted images(P < 0.0001). 33 patients with CRCC, they were all alive from3 years to 10 years follow-up, however, 13 patients with CCDC, of which 11 patients were able to be followed up, and 9 patients expired within 5 years of the initial diagnosis and the others are currently still alive.
CONCLUSIONS: Distinguishing features of CRCC and CCDC included calcifications, capsule signs, infiltrative appearance, metastasis, internal septations, mural nodules and signal on CT or MR images. These imaging features may help in differentiating the two renal tumor types.