■整个社区经历的灾难提供了机会,了解随着时间的推移,不良健康结果风险的个体差异。DNA甲基化(DNAm)差异可能有助于区分大规模灾难后风险增加的个体。
■研究女性表观遗传年龄加速与可能的创伤后应激障碍(PTSD)和PTSD症状严重程度的关系。
■这项前瞻性队列研究检查了妇女及其子女健康队列参与者的数据,在2010年深水地平线漏油事件(DHOS)以及美国墨西哥湾沿岸地区的众多飓风之后,他们的特征是纵向。第1波发生在2012年8月6日至2014年6月26日,第2波发生在2014年9月2日至2016年5月27日。数据在2023年8月18日至11月4日之间进行了分析。基于地址的抽样用于招募18至80岁的女性,居住在DHOS受影响地区周围的7个路易斯安那州教区中的1个。招募包括2个阶段的抽样,该抽样(1)对另外2个城市教区进行了欠抽样,以最大程度地提高参与者石油暴露的可能性,以及(2)在距泄漏最近的其他5个教区的人口普查范围内按比例招募了参与者。
■DHOS后的创伤后应激。
■通过从调查波1血样中测定的DNAm测量表观遗传年龄加速。在第2波调查中,使用DSM-5的PTSD清单评估创伤后应激障碍,并使用DSM-5的生活事件清单评估终生创伤暴露。一般线性模型用于检查第1波DNAm年龄和第2波可能的PTSD诊断与症状严重程度之间的关联。
■共有864名女性(平均[SD]年龄,47.1[12.0]年;328黑色[38.0%],19美洲印第安人[2.2%],486白色[56.3%],和其他30个种族群体,包括已知或未报告的[3.5%])。与白人参与者相比,黑人和美洲印第安人参与者在第1波的年龄加速度更高(β=1.64[95%CI,1.02-2.45]和2.34[95%CI,0.33-4.34],分别),并且他们在第2波时有更高的PTSD症状严重程度(β=7.10[95%CI,4.62-9.58]和13.08[95%CI,4.97-21.18],分别)。第1波时的表观遗传年龄加速与第2波时的PTSD症状严重程度相关,吸烟,身体质量指数,和家庭收入(β=0.38;95%CI,0.11-0.65)。
■在这项队列研究中,在少数族裔群体中,表观遗传年龄加速度更高,并且与未来的PTSD诊断和严重程度相关。这些发现支持对创伤反应进行心理教育的必要性,以增加在出现多年的痛苦和症状和合并症之前寻求治疗的可能性。
UNASSIGNED: Disasters experienced by an entire community provide opportunities to understand individual differences in risk for adverse health outcomes over time. DNA methylation (DNAm) differences may help to distinguish individuals at increased risk following large-scale disasters.
UNASSIGNED: To examine the association of epigenetic age acceleration with probable posttraumatic stress disorder (PTSD) and PTSD symptom severity in women.
UNASSIGNED: This prospective cohort study examined data from participants in the Women and Their Children\'s Health cohort, who were characterized longitudinally following the Deepwater Horizon oil spill (DHOS) in 2010 and through numerous hurricanes in the Gulf Coast region of the US. Wave 1 occurred August 6, 2012, through June 26, 2014, and wave 2 occurred September 2, 2014, through May 27, 2016. Data were analyzed between August 18 and November 4, 2023. Address-based sampling was used to recruit women aged 18 to 80 years and residing in 1 of the 7 Louisiana parishes surrounding the DHOS-affected region. Recruitment consisted of 2-stage sampling that (1) undersampled the 2 more urban parishes to maximize probability of participant oil exposure and (2) proportionally recruited participants across census tracts in the 5 other parishes closest to the spill.
UNASSIGNED: Posttraumatic stress subsequent to the DHOS.
UNASSIGNED: Epigenetic age acceleration was measured by DNAm assayed from survey wave 1 blood samples. Posttraumatic stress disorder was assessed using the PTSD Checklist for DSM-5 at survey wave 2, and lifetime trauma exposure was assessed using the Life Events Checklist for DSM-5. General linear models were used to examine the association between wave 1 DNAm age and wave 2 probable PTSD diagnosis and symptom severity.
UNASSIGNED: A total of 864 women (mean [SD] age, 47.1 [12.0] years; 328 Black [38.0%], 19 American Indian [2.2%], 486 White [56.3%], and 30 of other racial groups, including uknown or unreported [3.5%]) were included. Black and American Indian participants had a higher age acceleration at wave 1 compared with White participants (β = 1.64 [95% CI, 1.02-2.45] and 2.34 [95% CI, 0.33-4.34], respectively), and they had higher PTSD symptom severity at wave 2 (β = 7.10 [95% CI, 4.62-9.58] and 13.08 [95% CI, 4.97-21.18], respectively). Epigenetic age acceleration at wave 1 was associated with PTSD symptom severity at wave 2 after adjusting for race, smoking, body mass index, and household income (β = 0.38; 95% CI, 0.11-0.65).
UNASSIGNED: In this cohort study, epigenetic age acceleration was higher in minoritized racial groups and associated with future PTSD diagnosis and severity. These findings support the need for psychoeducation about traumatic responses to increase the likelihood that treatment is sought before years of distress and entrenchment of symptoms and comorbidities occur.